Predictors of the effects of smoking cessation on the endothelial function of conduit and digital vessels

Fukumoto, Kozo; Takemoto, Yasuhiko; Norioka, Naoki; Takahashi, Kanae; Namikawa, Hiroki; Tochino, Yoshihiro; Shintani, Ayumi; Yoshiyama, Minoru; Shuto, Taichi

doi:10.1038/s41440-020-0516-z

Cited by 14 publications

(17 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This response being not fully endothelium-specific is further supported by studies showing poor comparability of results of digital post-occlusive hyperaemia with other microvascular assessments such as laser Doppler flowmetry with iontophoresis of an endothelium-dependent stimulus [ 63 , 64 ]. Moreover, the reactive hyperaemia is minimally affected after smoking cessation [ 65 , 66 ], while smoking is a well-known trigger for oxidative stress and its effects on NO-dependent endothelial vasodilatation [ 67 , 68 ]).…”

Section: Evidence Of Microvascular Dysfunction In Hfpefmentioning

confidence: 99%

The Role of Systemic Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction

et al. 2022

View full text Add to dashboard Cite

Heart failure with preserved ejection fraction (HFpEF) is a condition with increasing incidence, leading to a health care problem of epidemic proportions for which no curative treatments exist. Consequently, an urge exists to better understand the pathophysiology of HFpEF. Accumulating evidence suggests a key pathophysiological role for coronary microvascular dysfunction (MVD), with an underlying mechanism of low-grade pro-inflammatory state caused by systemic comorbidities. The systemic entity of comorbidities and inflammation in HFpEF imply that patients develop HFpEF due to systemic mechanisms causing coronary MVD, or systemic MVD. The absence or presence of peripheral MVD in HFpEF would reflect HFpEF being predominantly a cardiac or a systemic disease. Here, we will review the current state of the art of cardiac and systemic microvascular dysfunction in HFpEF (Graphical Abstract), resulting in future perspectives on new diagnostic modalities and therapeutic strategies.

show abstract

Section: Evidence Of Microvascular Dysfunction In Hfpefmentioning

confidence: 99%

The Role of Systemic Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Furthermore, we quantified the functional status of the forearm microvasculature by comparing dermal baseline perfusion of conventional OCT-A images to peak reactive hyperemia perfusion of RH-OCT-A images. We propose that this comparison could be used to provide a more functional analysis of the microvasculature similar to the flow-mediated dilation and the reactive hyperemia peripheral artery tonometry techniques which are used to measure endothelial function of vessels 30 .…”

Section: Introductionmentioning

confidence: 99%

Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography

Wang-Evers

Casper

Glahn

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Visualization and quantification of the skin microvasculature are important for studying the health of the human microcirculation. We correlated structural and pathophysiological changes of the dermal capillary-level microvasculature with age and blood pressure by using the reactive hyperemia optical coherence tomography angiography (RH-OCT-A) technique and evaluated both conventional OCT-A and the RH-OCT-A method as non-invasive imaging alternatives to histopathology. This observational pilot study acquired OCT-A and RH-OCT-A images of the dermal microvasculature of 13 young and 12 old healthy Caucasian female subjects. Two skin biopsies were collected per subject for histological analysis. The dermal microvasculature in OCT-A, RH-OCT-A, and histological images were automatically quantified and significant indications of vessel rarefaction in both old subjects and subjects with high blood pressure were observed by RH-OCT-A and histopathology. We showed that an increase in dermal microvasculature perfusion in response to reactive hyperemia was significantly lower in high blood pressure subjects compared to normal blood pressure subjects (117% vs. 229%). These results demonstrate that RH-OCT-A imaging holds functional information of the microvasculature with respect to physiological factors such as age and blood pressure that may help to monitor early disease progression and assess overall vascular health. Additionally, our results suggest that RH-OCT-A images may serve as a non-invasive alternative to histopathology for vascular analysis.

show abstract

“…The measurement of RH-PAT is less operator-dependent than that of FMD. Although FMD reflects endothelial function in the conduit arteries and RH-PAT reflects endothelial function in the peripheral resistance arteries, it has been shown that the two methods are not closely related [3]. While FMD and RH-PAT may not be interchangeable markers, several prospective studies have demonstrated that they are both independent predictors of future cardiovascular events [4], and both methods have acceptable reproducibility.…”

mentioning

confidence: 99%

“…This is an important issue in clinical practice. In their study, Fukumoto et al [3] attempted to determine which method was better for assessing improvement in vascular endothelial function after successful smoking cessation. To achieve this objective, they used simultaneous measurement of FMD and RH-PAT.…”

mentioning

confidence: 99%

Which is the best method in clinical practice for assessing improvement in vascular endothelial function after successful smoking cessation — Flow-mediated dilation (FMD) or reactive hyperemic peripheral arterial tonometry (RH-PAT)?

Kato

2020

Hypertens Res

View full text Add to dashboard Cite

Predictors of the effects of smoking cessation on the endothelial function of conduit and digital vessels

Cited by 14 publications

References 21 publications

The Role of Systemic Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction

The Role of Systemic Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction

Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography

Which is the best method in clinical practice for assessing improvement in vascular endothelial function after successful smoking cessation — Flow-mediated dilation (FMD) or reactive hyperemic peripheral arterial tonometry (RH-PAT)?

Contact Info

Product

Resources

About