2022
DOI: 10.2337/dc21-2612
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Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study

Abstract: OBJECTIVE To distinguish among predictors of seroconversion, progression to multiple autoantibodies and from multiple autoantibodies to type 1 diabetes in young children. RESEARCH DESIGN AND METHODS Genetically high-risk newborns (n = 8,502) were followed for a median of 11.2 years (interquartile range 9.3–12.6); 835 (9.8%) developed islet autoantibodies and 283 (3.3%) were diagnosed with type 1 diabetes. Predictors were exam… Show more

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Cited by 35 publications
(15 citation statements)
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“…Children who develop multiple islet autoantibodies usually progress to clinical type 1 diabetes within 10 years . Susceptibility for early islet autoimmunity is conferred by genes involved in immunity, islet β-cell function, and responses to viral infections . Although the cause of islet autoimmunity is unknown, suspected contributors include early viral infections including respiratory viral infections …”
Section: Introductionmentioning
confidence: 99%
“…Children who develop multiple islet autoantibodies usually progress to clinical type 1 diabetes within 10 years . Susceptibility for early islet autoimmunity is conferred by genes involved in immunity, islet β-cell function, and responses to viral infections . Although the cause of islet autoimmunity is unknown, suspected contributors include early viral infections including respiratory viral infections …”
Section: Introductionmentioning
confidence: 99%
“…It is noteworthy that the case median age at IA seroconversion in the ENDIA NCC study was close to 17 months of age (median age years 1.37, IQR 0.95, 2.56). While the persistent IA outcome includes single IA and multiple IA, children as young as this would be expected to progress to T1D more frequently than older children with single IA [ 2 ] as reported in analyses of rates of progression according to the number of islet autoantibodies [ 22 , 23 ].…”
Section: Methodsmentioning
confidence: 99%
“…ENDIA addresses the hypothesis that modifiable environmental exposures in the prenatal and early postnatal period increase the penetrance of T1D risk genes and drive the development of IA progressing to clinical T1D in children. As the onset of islet autoimmunity at a young age [ 2 ], predicts progression to T1D, there is high interest in the gestational environment exposures and maternal – child transmission at birth. ENDIA is positioned amongst other large at-risk cohorts [ 3–6 ] that have recruited from three months onwards after birth, to provide a unique perspective on the significance of early-life antecedent factors in childhood T1D, by investigating exposures during pregnancy and the perinatal period in accordance with the Developmental Origins of Health and Disease (DOHaD) [ 7 ] paradigm.…”
Section: Introductionmentioning
confidence: 99%
“…This could indicate that n -3 fatty acids play a role in the initiation of the disease process, while other factors may play a stronger role in progression to T1D. Partly different risk factors for islet autoimmunity and development of T1D have been observed in other studies as well [ 12 , 13 , 39 ].…”
Section: N -3 Fatty Acids Islet Autoimmunity and T1dmentioning
confidence: 73%