Predictors of venous thromboembolism recurrence and the bleeding events identified using a Japanese healthcare database

Nakamura, Mashio; Yamada, Norikazu; Oda, Eri; Matsubayashi, Daisuke; Ota, Kaori; Kobayashi, Masafumi; Matsushita, Yasuyuki; Kaburagi, Jumpei; Ibusuki, Kei; Takita, Atsushi; Iwashita, Mikio; Yamaguchi, Takuhiro

doi:10.1016/j.jjcc.2016.10.012

Cited by 18 publications

(18 citation statements)

References 18 publications

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“…In this study, 1.8- and 1.6-fold increased risks of VTE were found for male and female antipsychotic users, respectively. In a cohort study [ 50 ] undertaken in a Japanese acute-care hospital, the rate of recurrence of VTE events was 7.2 per 100 patient-years in patients with a previous VTE. Three predictors for recurrent VTE were identified: malignant disease, antipsychotic drug use and non-steroidal anti-inflammatory drug (NSAID) use.…”

Section: Cohort Studiesmentioning

confidence: 99%

Venous Thromboembolism During Treatment with Antipsychotics: A Review of Current Evidence

et al. 2018

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This article summarises the current evidence on the risk of venous thromboembolism (VTE) with the use of antipsychotics. An increasing number of observational studies indicate an elevated risk of VTE in antipsychotic drug users. Although the use of certain antipsychotics has been associated with VTE, current data can neither conclusively verify differences in occurrence rates of VTE between first- and second-generation antipsychotics or between individual compounds, nor identify which antipsychotic drugs have the lowest risk of VTE. The biological mechanisms involved in the pathogenesis of this adverse drug reaction are still to be clarified but hypotheses such as drug-induced sedation, obesity, increased levels of antiphospholipid antibodies, enhanced platelet aggregation, hyperhomocysteinaemia and hyperprolactinaemia have been suggested. Risk factors associated with the underlying psychiatric disorder may at least partly explain the increased risk. Physicians should be aware of this potentially serious and even sometimes fatal adverse drug reaction and should consider discontinuing or switching the antipsychotic treatment in patients experiencing a VTE. Even though supporting evidence is limited, prophylactic antithrombotic treatment should be considered in risk situations for VTE.

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Section: Cohort Studiesmentioning

confidence: 99%

Venous Thromboembolism During Treatment with Antipsychotics: A Review of Current Evidence

et al. 2018

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“…50% of patients with image-proved DVT are asymptomatic. 1 Thrombus that does not lead to complete venous obstruction is silent. Many clinical and surgical circumstances not only lead to the development of DVT but also can occur in healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Silent Deep Venous Thrombosis after Laparoscopic Bariatric Surgery in Patients Who Received Combined Mechanical and Chemical Thromboprophylaxis Compared to Patients Who Received Mechanical Thromboprophylaxis Only

et al. 2020

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Background. This prospective randomized study compares the incidence of silent deep venous thrombosis (DVT) among 2 groups of patients who underwent laparoscopic bariatric surgery. The first group received mechanical thromboprophylaxis only, while the second group received a combination of mechanical and chemical thromboprophylaxis. Methods. This study included 150 morbidly obese patients who underwent primary one-stage laparoscopic bariatric surgery (sleeve gastrectomy and mini-gastric bypass) over a 6-month period. Patients were randomly assigned to 2 groups: group A (n = 75) was subjected to mechanical thromboprophylaxis in the form of perioperative elastic stockings on both lower limbs and early postoperative ambulation, and group B (n = 75) was subjected to combined mechanical thromboprophylaxis and chemical thromboprophylaxis in the form of 40 mg subcutaneous enoxaparin 12 hours before surgery and postoperative enoxaparin (40 mg subcutaneous every 24 hours) for 2 weeks. Bilateral lower limb venous duplex was done for all patients before discharge, on the second and fourth weeks postoperatively, to detect silent DVT. Results. Nine patients out of 150 patients developed silent DVT (6%). All patients among group A were subjected to mechanical thromboprophylaxis only (12%) [ P = .247, relative risk: .45, 95% confidence interval; .37-.62]. There was no silent DVT among group B who received combined mechanical and chemical thromboprophylaxis. No bleeding complications were reported in both groups. Conclusion. Combined mechanical and mechanical thromboprophylaxis is effective and safe in the prevention of silent DVT after laparoscopic bariatric surgery. Trial registration: The trial was registered in the Thai Clinical Trials Registry (TCTR20200127002) on January 20, 2020 retrospectively.

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“…Furthermore, the risk of recurrent VTE while on anticoagulant treatment is particularly high in patients with cancer, as is the risk of bleeding complications [8][9][10][11]. Using a Japanese healthcare database, Nakamura et al also demonstrated that malignant disease was a predictor of recurrent VTE as well as bleeding [12].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effects of edoxaban, an oral direct factor Xa inhibitor, on venous thromboembolism between patients with and without cancer

Ikeda

Koga

Yamagata

et al. 2018

Journal of Cardiology

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Predictors of venous thromboembolism recurrence and the bleeding events identified using a Japanese healthcare database

Abstract: These findings obtained from healthcare database suggest predictors either for recurrent VTE and bleeding that should be considered when selecting treatment to reduce the risk of recurrent VTE and mitigate bleeding.

Cited by 18 publications

References 18 publications

Venous Thromboembolism During Treatment with Antipsychotics: A Review of Current Evidence

Venous Thromboembolism During Treatment with Antipsychotics: A Review of Current Evidence

Incidence of Silent Deep Venous Thrombosis after Laparoscopic Bariatric Surgery in Patients Who Received Combined Mechanical and Chemical Thromboprophylaxis Compared to Patients Who Received Mechanical Thromboprophylaxis Only

Comparison of the effects of edoxaban, an oral direct factor Xa inhibitor, on venous thromboembolism between patients with and without cancer

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