Predisposition to Acute Respiratory Infections Among Preadolescent Children With Overweight. Epidemiologic Study in Poland

Jędrychowski, Wiesław; Maugeri, U; Mróz, Elżbieta; Bianchi, Ivan

doi:10.1097/00001648-199807001-00395

Cited by 16 publications

(22 citation statements)

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“…16 Overweight children (BMI Ն 20 kg/m 2 ) have been shown to be more susceptible to acute respiratory infections than non-obese children. 17 A diet with nutritional deficiencies may impair the immunocompetence of obese people. 17 Obesity has been associated with alterations in various measures of immune function, 18 which may also explain the elevated risk for infections.…”

Section: Discussionmentioning

confidence: 99%

“…17 A diet with nutritional deficiencies may impair the immunocompetence of obese people. 17 Obesity has been associated with alterations in various measures of immune function, 18 which may also explain the elevated risk for infections. In addition, obesity itself is an inflammatory state and associated with hsCRP, a marker of systemic low-grade inflammation.…”

Section: Discussionmentioning

confidence: 99%

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Risk factors for acute respiratory tract illness in military conscripts

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk factors for acute respiratory tract illness in military conscripts

et al. 2008

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“…Obesity has been associated with increased incidences of respiratory viral infections [8] and impaired vaccine efficacy [9], and was identified as a risk factor for the 2009 H1N1 influenza pandemic [10]. Persistent viral infections such as adenovirus-36 and herpes simplex virus-1 (HSV-1) are also more prevalent among obese adults and children [11,12], indicating that obesity may be associated with an impaired ability to defend against invading pathogens.…”

Section: Introductionmentioning

confidence: 99%

Excess body mass is associated with T cell differentiation indicative of immune ageing in children

Spielmann

Johnston

O’Connor

et al. 2014

Clinical and Experimental Immunology

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SummaryObesity has been associated with accelerated biological ageing and immunosenescence. As the prevalence of childhood obesity is increasing, we wanted to determine if associations between obesity and immunosenescence would manifest in children. We studied 123 Mexican American adolescents aged 10-14 (mean 12·3 ± 0·7) years, with body weights ranging from 30·1 to 115·2 kg (mean 52·5 ± 14·5 kg). Blood samples were obtained to determine proportions of naive, central memory (

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“…Patients with increased BMI and adiposity also present a higher incidence of surgical site infections, which have been associated with increased risk of other wound complications, increased length of stay, and increased risk of death (4)(5)(6)(7)(8). Obesity also negatively affects pulmonary function and BMI has been correlated to increased susceptibility to communityrelated respiratory tract infections (9)(10)(11)(12).…”

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Diet-Induced Obesity Impairs the T Cell Memory Response to Influenza Virus Infection

Karlsson

Sheridan

Beck

2010

The Journal of Immunology

212

190

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The global obesity epidemic combined with yearly influenza outbreaks and potential for a pandemic makes it crucial to determine how protection from influenza differs in an obese host. In contrast to a vaccine antibody response which recognizes surface proteins, memory T cells generated during a primary infection target internal viral proteins and are protective against heterologous strains. As our prior work demonstrated that obese mice have an impaired primary response to influenza virus infection, we hypothesized that obese mice would also have an impaired memory response to a secondary influenza infection. To test this hypothesis, obese and lean mice were infected with influenza X‐31. At 31 days post infection, mice were challenged with a lethal dose of a different strain, influenza A/PR/8. While lean mice were protected from lethal infection, obese mice had 25% mortality, increased lung pathology and virus titers, reduced antiviral cytokine expression, and decreased and delayed adaptive immune cytokine expression following secondary challenge. These results indicate that memory response to influenza in obese mice is significantly altered and ineffective and obesity may hinder the generation or function of these protective cells. These results suggest obese populations are at risk for impaired immune memory response, which has significant public health implications for current vaccination protocols. Grant Funding Source DK56350

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Predisposition to Acute Respiratory Infections Among Preadolescent Children With Overweight. Epidemiologic Study in Poland

Cited by 16 publications

References 0 publications

Risk factors for acute respiratory tract illness in military conscripts

Risk factors for acute respiratory tract illness in military conscripts

Excess body mass is associated with T cell differentiation indicative of immune ageing in children

Diet-Induced Obesity Impairs the T Cell Memory Response to Influenza Virus Infection

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