Prednisolone treatment reduces endometrial spiral artery development in women with recurrent miscarriage

Lash, Gendie E.; Bulmer, Judith N.; Innes, Barbara A.; Drury, Josephine A.; Robson, Stephen C.; Quenby, Siobhán

doi:10.1007/s10456-011-9237-x

Cited by 23 publications

(12 citation statements)

References 39 publications

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“…When prednisolone treatment was given, endometrial natural killer cells were reduced 21 without a change of the total number of endometrial blood vessels, but the percentage of vessels completely surrounded by VSMC was decreased. 53…”

Section: Discussionmentioning

confidence: 99%

Dysregulated uterine natural killer cells and vascular remodeling in women with recurrent pregnancy losses

Elazzamy

Dambaeva

Katukurundage

et al. 2018

American J Rep Immunol

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Section: Discussionmentioning

confidence: 99%

Dysregulated uterine natural killer cells and vascular remodeling in women with recurrent pregnancy losses

Elazzamy

Dambaeva

Katukurundage

et al. 2018

American J Rep Immunol

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“…These vessels lead to high-resistance indices upon ultrasound examination (Quenby et al 2009). Clinical trials were initiated to examine prednisolone as an intervention to decrease uNK cell number and consequently RSA (Lash et al 2011b). Prednisolone decreased uNK cell number in certain women and, in treated women who subsequently had a successful pregnancy, secretory endometrial vessel density was decreased (Lash et al 2011b).…”

Section: Unk Cells and Pregnancy Complicationsmentioning

confidence: 99%

Uterine natural killer cells: supervisors of vasculature construction in early decidua basalis

et al. 2015

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Mammalian pregnancy involves tremendous de novo maternal vascular construction to adequately support conceptus development. In early mouse decidua basalis (DB), maternal uterine natural killer (uNK) cells oversee this process directing various aspects during the formation of supportive vascular networks. The uNK cells recruited to early implantation site DB secrete numerous factors that act in the construction of early decidual vessels (neoangiogenesis) as well as in the alteration of the structural components of newly developing and existing vessels (pruning and remodeling). Although decidual and placental development sufficient to support live births occur in the absence of normally functioning uNK cells, development and structure of implantation site are optimized through the presence of normally activated uNK cells. Human NK cells are also recruited to early decidua. Gestational complications including recurrent spontaneous abortion, fetal growth restriction, preeclampsia, and preterm labor are linked with the absence of human NK cell activation via paternally inherited conceptus transplantation antigens. This review summarizes the roles that mouse uNK cells normally play in decidual neoangiogenesis and spiral artery remodeling in mouse pregnancy and briefly discusses changes in early developmental angiogenesis due to placental growth factor deficiency.Reproduction (2015) 149 R91-R102

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“…Moreover, PSL treatment modified the endometrial environment for embryogenesis and maintenance of pregnancy through reduction of the numbers of endometrial macrophages and uNKs [27] [28], which suppressed the cytolytic activity of NK cells [11] and associated highly muscularised vessels [28]. The present study showed that the combination of PSL and SEET may be a useful adjunct to assisted reproductive technology in women who repeatedly fail to conceive by infertility treatment.…”

Section: Discussionmentioning

confidence: 56%

Improvement of Live Birth Rate Following Frozen-Thawed Blastocyst Transfer by Combination of Prednisolone Administration and Stimulation of Endometrium Embryo Transfer

Inoue¹,

Ono²,

Yonezawa³

et al. 2014

OJOG

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The endometrial condition is a significant factor for successful pregnancy. To regulate endometrial function in fertility treatment, prednisolone (PSL) is administered for suppression of increased natural killer cells and stimulation of endometrium embryo transfer (SEET) to enhance communication between embryo and maternal tissues. We attempted to improve the endometrial condition by PSL administration and SEET during frozen-thawed blastocyst transfer (FBT). Patients took PSL (5 mg) 3 times daily for 3 days after ovulation during the FBT cycle. To analyse effects of PSL combined with SEET, we determined rates of chemical pregnancy, clinical pregnancy, foetal heart movement (FHM) and live birth. Rates of chemical pregnancy, clinical pregnancy and FHM were significantly higher in the PSL(+)/SEET(+) (57.7%, 50.0% and 46.2%, respectively) and PSL(+)/SEET (−) (53.3%, 46.7% and 46.7%, respectively) groups than in the PSL(−)/SEET(+) (30.3%, 18.2% and 18.2%, respectively) and PSL(−)/SEET(−) (22.4%, 22.4% and 18.4%; P = 0.0043, 0.0081 and 0.0055, respectively) groups. The live birth rate was significantly higher in the PSL(+)/SEET(+) group than in the PSL(+)/SEET(−), PSL(−)/SEET(+) and PSL(−)/SEET(−) groups (42.3%, 26.7%, 18.2% and 12.2%, respectively; P = 0.0237). PSL combined with SEET may be a useful adjunct to assisted reproductive technology in women who repeatedly fail to conceive by infertility treatment.

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Prednisolone treatment reduces endometrial spiral artery development in women with recurrent miscarriage

Abstract: The effect of prednisolone therapy for some women with RM may be due to altered endometrial angiogenic growth factor expression and reduced blood vessel maturation.

Cited by 23 publications

References 39 publications

Dysregulated uterine natural killer cells and vascular remodeling in women with recurrent pregnancy losses

Dysregulated uterine natural killer cells and vascular remodeling in women with recurrent pregnancy losses

Uterine natural killer cells: supervisors of vasculature construction in early decidua basalis

Improvement of Live Birth Rate Following Frozen-Thawed Blastocyst Transfer by Combination of Prednisolone Administration and Stimulation of Endometrium Embryo Transfer

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