Predominant association of Raoultella bacteremia with diseases of the biliary tract

Abstract

A case series of 14 patients with Raoultella bacteremia was compared with 28 Klebsiella oxytoca and 28 Klebsiella pneumoniae bacteremia cases. Forty-three percent of Raoultella bacteremia cases were associated with biliary tract disease, compared to 32% and 22% of patients with K. oxytoca and K. pneumoniae bacteremia, respectively.

Emerging role of Raoultella ornithinolytica in human infections: a series of cases and review of the literature

“…As well as the well-known clinical presentations of R. ornithinolytica infections, such as primary or cholangitis bloodstream infection, [3][4][5]7,14,16,18,20,22 catheter-related bloodstream infection, 8,26 biliary tract infection, 3-5 urinary tract infection, 5,15,21 and skin infection, 19,20 cases of respiratory infection including community-and hospital-acquired pneumonia and pleural effusion were also identified in this study, and these have been poorly reported. Boattini et al recently reported three cases of community-acquired pneumonia and three cases of hospital-acquired pneumonia among 25 cases of R. ornithinolytica infection over a 5-year period in six university hospital centres in Lisbon.…”

“…This series of human infections caused by R. ornithinolytica managed at four university hospital centres in France over the last 12 years is the largest reported to date. A literature search identified 86 reported cases of R. ornithinolytica (formerly Klebsiella ornithinolytica), [3][4][5][6][7][8][14][15][16][17][18][19][20][21][22][23][24][25][26][27] and half of these cases were reported in 2015. 10,12,[24][25][26] A high rate of hospital-acquired infection was observed in the present study (49%), which may be explained by the high proportion of patients who had undergone invasive procedures (48%) involving, for example, urinary catheters, mechanical ventilation, and port catheters.…”

“…21 Among the 86 isolates reported in the literature, 80% were resistant to amoxicillin, 17% to amoxicillin-clavulanic acid, 10% to third-generation cephalosporins, 12% to quinolones, 13% to co-trimoxazole, 15% to piperacillin-tazobactam, 7% to aminosides, and 7% to carbapenems. [3][4][5][6][7][8][14][15][16][17][18][19][20][21][22][23][24][25][26][27] Few of these studies reported cases of R. ornithinolytica infection with isolates resistant to multiple antibiotics, including KPC 14 and NDM-1 strains. 27 In this study, the proportions of isolates resistant to ceftriaxone, quinolones, and aminosides were a little bit lower than reported in the literature (4%, 6%, and 1%, respectively).…”

“…Many cases of biliary tract infection, urinary infection, and bacteraemia caused by R. ornithinolytica have been reported. [3][4][5][6][7][8] However, the clinical features, antimicrobial susceptibility, and clinical outcomes of R. ornithinolytica infection have not yet been well elucidated.…”

Comparison of different methods for identification of species of the genus Raoultella: report of 11 cases of Raoultella causing bacteraemia and literature review

“…However, the incidence of isolation of R. ornithinolytica and R. planticola as human clinical pathogens is growing, mostly attributed to the use of molecular identification techniques in clinical microbiology laboratories that more precisely distinguish this genus and its species than those methods based on phenotypic features [2,3]. Until the middle of the 2015, 80 cases of bacteraemia due to Raoultella had been reported [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Most of the cases involved R. ornithinolytica and R. planticola and the primary sites of infection were diverse.…”