Predominant Symptom Behavior in Patients With Persistent Dyspepsia During Treatment

Abstract

In the majority of dyspeptic patients, symptoms change continuously as time goes on. Symptom instability is not influenced by diagnostic procedures or therapy. Thus, there is little sense in symptom-based management of dyspepsia in primary care.

Comparison of the effects of omeprazole and famotidine in treatment of upper abdominal symptoms in patients with reflux esophagitis

“…In the present study, an average of 5.2 symptoms were seen in patients with reflux esophagitis, of which reflux type symptoms occurred most frequently; however, dysmotility type symptoms and ulcer type symptoms were also observed in about 40-50% of patients. Similar numbers (5.4 on average) were reported from other studies in patients with upper abdominal symptoms possibly associated with acid [13,14]. A recent study reported that more than 50% of patients with FD had at least five symptoms [15].…”

Proton pump inhibitor versus prokinetic therapy in patients with functional dyspepsia: is therapeutic response predicted by Rome III subgroups?

“…Nonetheless, it remains unknown how to identify subgroups of patients for whom a specific treatment modality is most suitable. The previous Rome II subdivision of functional dyspepsia had limited clinical impact because the subgrouping was unstable over a short period of time, and it was difficult to ascertain the ''predominant'' symptom as well as the meaning of ''discomfort'' [9,32]. It has been hoped that the Rome III subclassification would distinguish patients with distinct pathophysiological mechanisms and thus permit more specific management in each subgroup [1].…”

Functional dyspepsia: past, present, and future

“…5 However, subsequent research has shown that identifi cation of the predominant symptom lacks stability over a short time period. 8,9 Nevertheless, there is increasing evidence of heterogeneity of FD based on factor analyses in the general population and in referral populations ( Table 2). These analyses have failed to support the existence Epigastric refers to the region between the umbilicus and lower end of the sternum, marked by the midclavicular lines.…”