Preeclampsia and maternal risk of breast cancer: a meta-analysis of cohort studies

Sun, Ming; Fan, Yongling; Hou, Yuanyuan; Fan, Yanyan

doi:10.1080/14767058.2017.1342806

Cited by 26 publications

(29 citation statements)

References 31 publications

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“…Despite this, research has produced conflicting results. Three meta-analyses have shown no association or inconclusive results [ 4 , 14 , 15 ] with similar findings reported in large primary studies [ 16 , 17 , 18 , 19 ]. In contrast, two cohorts and a case-control study showed increased cancer risk [ 20 , 21 , 22 ].…”

Section: Introductionsupporting

confidence: 63%

Hypertensive Disorders of Pregnancy (HDP) and the Risk of Common Cancers in Women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk Prospective Population-Based Study

Pasdar

Gamble

Myint

et al. 2020

Cancers

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Purpose: The purpose was to determine the association between HDP and cancer in a UK cohort. Methods: Between 1993 and 1997, participants from the EPIC-Norfolk cohort attended baseline health-checks and completed questionnaires, where a history of HDP was collected. Incident cancer cases were identified through NHS record linkage until March 2016. Univariable and multivariable logistic regression analyses were employed to determine the association between HDP and odds of cancer, with adjustment for potential confounders including co-morbidities, sociodemographic, lifestyle and reproductive factors. Results: 13,562 women were included after excluding prevalent cancer cases and women with no pregnancies. 2919 (21.5%) reported HDP and 2615 incident cancers occurred during mean follow up of 19 years. Median age (IQR) at baseline for incident cancer was 60.8 (±14.8) years. Among incident cancer cases, 578 (22.1%) had HDP. In multivariable analyses, HDP had odds ratio (OR) 1.06; 95% CI 0.95–1.18 for incident cancer. The ORs (95% CIs) for common site-specific cancers including breast, colorectal, lung, ovarian and endometrial cancers were 1.06 (0.88–1.28), 1.15 (0.92–1.45), 0.96 (0.68–1.35), 1.30 (0.93–1.83) and 1.16 (0.80–1.67). Conclusion: We found no association between HDP and cancer risk. Further studies are required to confirm and account for any underlying genetic factors involved in pregnancy-related exposures and cancer risk.

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Section: Introductionsupporting

confidence: 63%

Hypertensive Disorders of Pregnancy (HDP) and the Risk of Common Cancers in Women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk Prospective Population-Based Study

Pasdar

Gamble

Myint

et al. 2020

Cancers

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“…In this large registry‐linked pooled study based on data from four Nordic countries, women with a history of preeclampsia had an ∼10% reduced risk of breast cancer compared with women without this history. A recent meta‐analysis of preeclampsia and breast cancer yielded a relative risk (RR) of 0.87 (95% CI 0.80–0.94) based on prospective studies, but results from historical cohort studies showed significant heterogeneity and a lack of association (RR 0.97; 95% CI 0.79–1.18). This study indicated that other maternal, perinatal and neonatal characteristics, such as twin pregnancies, lower maternal BMI and premature delivery also were associated with elevated breast cancer risk.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, prospective cohort studies have shown that preeclampsia, a pregnancy complication involving hypertension and proteinuria, is associated with a 10–20% decrease in maternal breast cancer risk . Gestational hypertension also has been associated with reduced risk, although less consistently.…”

mentioning

confidence: 99%

Pregnancy complications and subsequent breast cancer risk in the mother: a Nordic population‐based case–control study

Troisi

Ording

Grotmol

et al. 2018

Intl Journal of Cancer

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Certain features of pregnancy are important risk factors for breast cancer, such as protection afforded by young age at first birth. Preeclampsia, a pregnancy complication, is associated with reduced maternal breast cancer risk. However, questions remain regarding causality, biological mechanisms and the relation of other hypertensive conditions to risk. We conducted a population-based case-control study of breast cancer cases (n = 116,196) in parous women identified through linkage of birth and cancer registries in Denmark, Finland, Norway and Sweden (1967-2013), including up to 10 matched controls per case (n = 1,147,192) sampled from the birth registries (complete data were not available on all variables). Odds ratios (ORs) with 95% confidence intervals (CIs) were derived from unconditional logistic regression models including matching factors (country, maternal birth year) and parity. Hypertension diagnosed before pregnancy (OR 0.87; 95% CI 0.78-0.97), gestational hypertension (OR 0.90; 95% CI 0.86-0.93) and preeclampsia (OR 0.91; 95% CI 0.88-0.95) were associated with reduced breast cancer risk. Results remained similar after adjustment for smoking and maternal body mass index before first pregnancy, and were generally similar stratified by parity, age at breast cancer diagnosis, time since first and last birth, sex of the offspring and calendar time. Except for retained placenta (OR 1.14; 95% CI 0.98-1.32), no other pregnancy complication appeared associated with breast cancer risk. The mechanisms mediating the modest risk reductions for history of preeclampsia or hypertension preceding or arising during pregnancy, and possible increased risk with history of retained placenta are unknown and warrant further laboratory, clinical and epidemiological investigation.

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Section: Commentmentioning

confidence: 99%

“…All Sister Study participants had a sister diagnosed with breast cancer, which may occur less frequently following preeclampsia, although the overall evidence is controversial. 6,41,42 Still, sisters of women with breast cancer may have a lower risk of preeclampsia, possibly due to inherited factors. 43 Thus, we cannot rule out that Sister Study participants may differ in terms of preeclampsia risk (and, possibly, risk factors) from the general population.…”

Section: Limitations Of the Datamentioning

confidence: 99%

Mother’s age at delivery and daughters’ risk of preeclampsia

Basso

Weinberg

D’Aloisio

et al. 2019

Paediatric Perinatal Epid

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Background Some cardiovascular disease risk factors are associated with both risk of preeclampsia and having been born to a younger or older mother. We examined whether mother's age at delivery predicts a primiparous daughter's risk of preeclampsia. Methods The analysis included 39 803 Sister Study participants (designated as “daughters”) born between 1930 and 1974. Using log‐binomial regression, we estimated relative risks (RR) of preeclampsia in the first pregnancy ending in birth (“primiparous preeclampsia”) associated with mother's age at the daughter’s birth. Models included: number of older full and maternal half‐siblings, income level growing up, daughter's age at delivery, race/ethnicity, and 5‐year birth cohort. We examined self‐reported relative weight at age 10 (heavier than peers versus not) as a potential effect measure modifier. Results Overall, 6.2% of daughters reported preeclampsia. Compared with those who had been born to 20‐24‐year old mothers, daughters of teenage mothers had a relative risk of 1.20 (95% confidence interval (CI) 1.01, 1.43) and daughters of mothers ≥25 had a ~10% lower risk. Relative weight at age 10 modified the association, with an inverse association between mother's age at delivery and preeclampsia seen only among daughters with low/normal childhood relative weight. In this subset, results were consistent across strata of daughter's age at menarche and age at first birth. Conclusions These findings, based on self‐reported data, require replication. Nevertheless, as women increasingly delay childbearing, they provide some reassurance that having been born to an older mother is not, per se, a risk factor for primiparous preeclampsia.

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Preeclampsia and maternal risk of breast cancer: a meta-analysis of cohort studies

Abstract: Current evidence did not support a conclusive association between PE, PIH and the maternal risk of breast cancer. Gender of the offspring may influence the association between PE and maternal breast cancer incidence.

Cited by 26 publications

References 31 publications

Hypertensive Disorders of Pregnancy (HDP) and the Risk of Common Cancers in Women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk Prospective Population-Based Study

Hypertensive Disorders of Pregnancy (HDP) and the Risk of Common Cancers in Women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk Prospective Population-Based Study

Pregnancy complications and subsequent breast cancer risk in the mother: a Nordic population‐based case–control study

Mother’s age at delivery and daughters’ risk of preeclampsia

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