Preeclampsia: Should Plasma Albumin Level Be a Criterion for Severity?

Benoît, Janie; Rey, Évelyne

doi:10.1016/s1701-2163(16)35017-4

Cited by 16 publications

(9 citation statements)

References 14 publications

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“…For example, the value of platelet count and platelet indices in PE is supported by several studies; however, there are also studies that found no significance [23][24][25]. The significance of ALB in assessing the onset and severity of preeclampsia is also controversial [26,27].…”

Section: Introductionmentioning

confidence: 99%

Alterations of Several Serum Parameters Are Associated with Preeclampsia and May Be Potential Markers for the Assessment of PE Severity

Duan

Leung

et al. 2020

Disease Markers

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The precise pathophysiological mechanisms of preeclampsia (PE) and preventative strategies remain unknown. Laboratory markers which can help in identifying PE patients from pregnant women and assessing the severity of PE during pregnancy are worthy to be explored. In this study, a retrospective case-control study was designed to assess whether the serum levels of albumin (ALB), total protein (TP), prealbumin (PA), alkaline phosphatase (ALP), lactic dehydrogenase (LDH), D-dimer, fibrinogen (Fbg), platelet (PLT) count, mean platelet volume (MPV), and platelet distribution width (PDW) can help in assessing PE and evaluate its severity. 256 pregnant women were enrolled and classified into 3 groups: mild preeclampsia (mPE, n = 85), severe preeclampsia (sPE, n = 78), and healthy normotensive controls (control, n = 93). Our result showed that the serum levels of ALP, LDH, and D-dimer were significantly higher in mild or severe PE patients compared with the healthy controls (66 (52.

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Section: Introductionmentioning

confidence: 99%

Alterations of Several Serum Parameters Are Associated with Preeclampsia and May Be Potential Markers for the Assessment of PE Severity

Duan

Leung

et al. 2020

Disease Markers

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“…It is hypothesised that the widespread endothelial cell dysfunction causes a generalised capillary leak resulting in oedema, proteinuria, hypoalbuminaemia and decreased colloid osmotic pressure 15. Low-serum albumin levels, as was found in our case, is an indicator of severe PET 16. It is important that this is identified in women presenting with PET and monitored closely.…”

Section: Discussionsupporting

confidence: 55%

Severe hyponatraemia associated with pre-eclampsia

Anglim

Levins

Bussmann³

et al. 2016

BMJ Case Reports

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Pre-eclampsia as a rare cause of severe hyponatraemia Isotonic sodium chloride was carefully administered. She was delivered by caesarean section at 36+1 weeks because of persistent hyponatraemia and worsening symptoms of pre-eclampsia as well as suspected acute fatty liver (ALT 1348 iu/L; NR <40 iu/L). A male infant was born (Apgar score 9 at 10 minutes)-he had mild hyponatraemia-corrected by the paediatricians. Within 24 hours of delivery, maternal hyponatraemia had improved to 133 mmol/L. This is illustrated in Figure 1. Recovery was complicated by intrapartum sepsis. She was discharged eight days later with a normal BP. Discussion Pregnancy involves physiological changes affecting water/ sodium homeostasis. However, most women with PET do not develop hyponatraemia. A recent review of 332 pregnancies complicated by PET found hyponatraemia to occur more frequently in older age and twin gestations; 2 both features were absent in our patient. However, she had features of severe pre-eclampsia, including uncontrolled hypertension and impaired hepatic function. We postulate that this was a case of hyponatraemia with hypervolaemia (excess extracellular sodium and total body water) as a result of impaired free water clearance secondary to pre-eclampsia. SIADH was discounted because of low urinary sodium and oedema. We draw attention to severe hyponatraemia as a biomarker of severe pre-eclampsia and as a rare indication for urgent delivery. This requires multidisciplinary management and continuing postpartum care to ensure favourable maternal/ neonatal outcomes.

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“…The mean levels of sera protein, globulin, Alb/Glb ratio and blood glucose showed no significant change in group A [pregnant women with Preeclampsia] comparing to group B [healthy pregnant women], while albumin showed a significant decrease in group A when compared with group B (P<0.01) as shown in Table (1). In pregnancy, albumin decreases and variations over time [11]. This is may be due to an increase in plasma and interstitial volume, and possibly by an increase in albumin metabolism.…”

Section: Resultsmentioning

confidence: 93%

Determination of Plasma Osteopontin and Serum Inhibin B in Pregnant Women with Preeclampsia

Mehde

Mehdi

Mustafa

2014

JNUS

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Pre-eclampsia is a multisystem disorder of pregnancy, which complicates 3%-5% of pregnancies in the world .The present study deals with estimation of levels of Osteopontin, Inhibin B, protein, albumin, globulin and Alb./Glb. ratio in forty five Pregnant Women with Preeclampsia in comparison with thirty healthy Pregnant Women. In Pregnant Women with Preeclampsia, the level of Osteopontin and Inhibin B were significantly higher as compared to the normal subjects [p<0.01]. In Pregnant Women with Preeclampsia the levels of S. calcium S.Protein and albumin were significantly decreased as compared to the normal subjects [p<0.05, p<0.05and p<0.01] respectively. Based on findings of the present study, it can be concluded that Patients with Preeclampsia had significantly higher serum inhibin B and Osteopontin concentrations compared to healthy pregnant women. In addition, the current study could not determine any links between Osteopontin levels and other biochemical markers in this study.

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Preeclampsia: Should Plasma Albumin Level Be a Criterion for Severity?

Cited by 16 publications

References 14 publications

Alterations of Several Serum Parameters Are Associated with Preeclampsia and May Be Potential Markers for the Assessment of PE Severity

Alterations of Several Serum Parameters Are Associated with Preeclampsia and May Be Potential Markers for the Assessment of PE Severity

Severe hyponatraemia associated with pre-eclampsia

Determination of Plasma Osteopontin and Serum Inhibin B in Pregnant Women with Preeclampsia

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