Preeclamptic Decidual Microvascular Endothelial Cells Express Lower Levels of Matrix Metalloproteinase-1 Than Normals

Gallery, Eileen D.M.; Campbell, Suzanne; Arkell, Jacky; Nguyen, Minh Vu Chuong; Jackson, Chris

doi:10.1006/mvre.1998.2142

Cited by 42 publications

(24 citation statements)

References 20 publications

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“…Gallery et al [13] reported a decreased production of MMP1 and MMP1 mRNA by endothelia in the decidual spiral arteries of the placenta of preeclamptic women. The deletion of guanine at position -1607 from the MMP1 promoter is reported to decrease transcription [14,15].…”

Section: Discussionmentioning

confidence: 99%

“…In cell culture, endothelial cells isolated from the decidual arteries of preeclamptic placentas produced smaller amounts of MMP1 than endothelia from normal decidua, and the MMP1 to tissue inhibitor of metalloproteinase-1 (TIMP-1) production ratio was low too. After incubation with phorbol myristate acetate, a potent angiogenic factor capable of inducing protease activity in endothelial cells, there was an increase in MMP1 mRNA which was higher in normal decidual endothelial cells than those from preeclamptic placentas [13].…”

Section: Introductionmentioning

confidence: 99%

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Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension

Jurajda

Kaňková²,

Mužı́k³

et al. 2001

Gynecol Obstet Invest

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In preeclampsia the cytotrophoblast invasion of the decidual vessels is reduced. The endothelia in the decidual vessels may influence cytotrophoblast invasion and remodeling of decidual spiral arteries. The decidual endothelial cells from preeclamptic placentas produce less matrix metalloproteinase-1 (MMP1) than those from normal placentas. MMPs form a group of enzymes that are capable of degrading components of extracellular matrix. The present study investigated the prevalence and possible association of an insertion of guanine in the promoter of the MMP1 gene in pregnancy-induced hypertension, preeclampsia and eclampsia in the Czech population. This was a case-control study. No differences were observed in genotype frequencies between cases and controls. The insertion of the guanine in the promoter of the MMP1 gene does not appear to increase the risk of development of pregnancy-induced hypertension, preeclampsia and eclampsia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension

Jurajda

Kaňková²,

Mužı́k³

et al. 2001

Gynecol Obstet Invest

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“…Cytotrophoblasts and endothelial cells were isolated from biopsies of placenta and decidua at caesarean delivery as previously described 2,3 . Using these cells, we established cell bilayer co-culture in a membrane-insert system, using Millicell-PCF culture plate inserts, 12mm diameter (Millipore, Bedford, MA), in 24-well plates (Nunc, Roskilde, Denmark).…”

Section: Methodsmentioning

confidence: 99%

“…We have previously described a contribution from the host decidual endothelial cell population in regulating the de®cient vascular ingress of cytotrophoblasts in preeclampsia 2 . We now describe the development of a novel in vitro co-culture system which will permit more detailed examination of communication between human maternal decidual endothelial cells and invading cytotrophoblasts.…”

Section: Introductionmentioning

confidence: 99%

A novel in vitro co‐culture system for the study of maternal decidual endothelial cell–trophoblast interactions in human pregnancy

Gallery

Campbell

Ilkovski

et al. 2001

BJOG

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Investigation of the pathophysiology of pre-eclampsia (characterised by insuf®cient invasion of the intrauterine vasculature by cytotrophoblasts) has been hampered by the absence of a suitable animal model, and ethical constraints in clinical studies. We have developed a novel in vitro human cell co-culture system allowing direct assessment of cytotrophoblast invasion of a decidual endothelial cell monolayer from the abluminal side, as occurs in vivo. This model will facilitate detection, at the cellular level, of abnormal endothelial cell± trophoblast functional interactions in pre-eclampsia and other pregnancy disorders with abnormal placentation.

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“…The initial stage of AM degradation is mediated by a matrix metalloprotease. Recently basal levels of the matrix metalloprotease MMP-1 were shown to be lower in cultured decidual endothelial cells from a pre-eclamptic sample compared to normal decidual endothelial cells [93]. This decrease was also maintained following stimulation with phorbol myristate acetate.…”

Section: Pre-eclampsiamentioning

confidence: 96%

Adrenomedullin: Multiple functions in human pregnancy

et al. 2004

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Adrenomedullin is a 52 amino acid peptide originally isolated from human phaeochromocytoma in 1993. It was initially demonstrated to have profound effects on the vasculature including vasodilatation and subsequently promotion of angiogenesis. Since then it has become apparent that it has a wide range of other biological actions including regulation of cell growth and differentiation. Successful pregnancy outcome relies on establishing and maintaining throughout gestation an efficient blood supply to the fetus. This allows the exchange of nutrients, oxygenation of fetal blood and removal of cytotoxins from the fetus, such as carbon dioxide. One of the most important local adaptations to pregnancy is the change in maternal blood flow to the implantation site. Evidence now points towards a vital role for adrenomedullin in the regulation of placentation. It appears that adrenomedullin may play important roles in the regulation of fetal perfusion both in normal and in compromised pregnancies. However, most studies have focused on measuring adrenomedullin levels and studying its expression as well as that of its receptors. More functional studies are now required to elucidate the underlying mechanisms involved.

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Preeclamptic Decidual Microvascular Endothelial Cells Express Lower Levels of Matrix Metalloproteinase-1 Than Normals

Cited by 42 publications

References 20 publications

Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension

Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension

A novel in vitro co‐culture system for the study of maternal decidual endothelial cell–trophoblast interactions in human pregnancy

Adrenomedullin: Multiple functions in human pregnancy

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