Preemptive Analgesic Effects of Ketorolac in Ankle Fracture Surgery

Norman, Peter H.; Daley, M. Denise; Lindsey, Ronald W.

doi:10.1097/00000542-200104000-00012

Cited by 57 publications

(44 citation statements)

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“…Based on the aforementioned observations, the concept of pre-emptive analgesia has evolved. By administering an analgesic before the painful stimulus, the development of pain hypersensitization may be reduced or abolished, thus resulting in less post-operative pain [8].…”

Section: Discussionmentioning

confidence: 99%

“…Due to interference with renal and platelet function [8], ketorolac is preferably used in patients without any risk for the renal dysfunction and in the procedures that involve a minimal amount of blood loss.…”

Section: Discussionmentioning

confidence: 99%

“…The numerical rating scale was categorized as [0]-no pain, [1][2][3]-mild pain, [4][5][6]-moderate pain and [7][8][9][10]-severe pain. Time to 1st rescue analgesia, total number of analgesics consumed during the 5 post-operative days and patients' self assessment of overall evaluation of the efficacy of the surgery with regard to no pain were recorded.…”

Section: Follow Up Designmentioning

confidence: 99%

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Comparative Evaluation of Pre-Emptive Analgesic Efficacy of Intramuscular Ketorolac Versus Tramadol Following Third Molar Surgery

Shah¹,

Kumar

2012

J. Maxillofac. Oral Surg.

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Pre-emptive analgesia aims at preventing the central nervous system from reaching a hyper-excitable state known as central sensitization, in which it responds excessively to afferent inputs. The clinical implication would be more effective pain management, thereby reducing post-operative pain and analgesic requirements. This study aimed at investigating the existence of preemptive analgesia and to compare the pre-emptive analgesic efficacy of im ketorolac [NSAID] versus tramadol [SYNTHETIC OPIOD] for post-operative pain management following third molar surgery. Fifty patients under the age group of 16-25 years with asymptomatic, symmetrically impacted mandibular third molars were equally divided into 2 groups and underwent third molar surgery under local anesthesia. Ketorolac 30 mg and tramadol 50 mg were used in the study group, while sodium chloride 0.9 % was used in the control group. Study parameters included pain intensity scores for 12 post-operative hours, time to 1st rescue analgesia, total number of analgesics consumed during the 5 post-operative days and patients' self assessment of efficacy of the surgery with regardsto no pain. Statistically, the data are presented as the mean values with their standard deviations and a 95 % confidence interval [p is significant, if p \ 0.05] for the mean are applicable. Incidences of adverse events like pain on injection of the study drug, local reactions, nausea and vomiting were noted. Patients in the study group significantly performed better than the control group in terms of all the parameters; while among the study group, ketorolac fared better than tramadol. All the drug related complications were mild and did not require any intervention. Preoperative ketorolac or tramadol in comparison to placebo resulted in a significantly better post-operative pain management. However as against tramadol, ketorolac is a better choice as a pre-emptive analgesic agent for the post-operative pain management following third molar surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Follow Up Designmentioning

confidence: 99%

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Comparative Evaluation of Pre-Emptive Analgesic Efficacy of Intramuscular Ketorolac Versus Tramadol Following Third Molar Surgery

Shah¹,

Kumar

2012

J. Maxillofac. Oral Surg.

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“…대한 기억을 방해하거나 통증 인지를 저하시키는 것으로 정의된 다 (Kaufman, Epstein, Gorsky, Jackson, & Kadari, 2005;Marret et al, 2005;Norman et al, 2001;Ochroch, Mardini, & Gottschalk, 2003). 몇몇 선행 연구에서 선행진통법이 수술 후 진통제 투여량을 감소시키고 부작용을 완화시키는 것으 로 보고하고 있다 (Grass, 2005;Kim & Yoon, 2006;Marret et al, 2005;White, 2005).…”

Section: 선행진통법은 외과적 자극을 주기 전 제통 요법을 통해 통증에unclassified

“…자가 통증 조절법에는 morphine, pethidine과 fentanyl 등의 아편양 제제와 비스테로이드성 소염진통제(NonSteroidal AntiInflammatory Drugs, NSAIDs)를 사용하고 있다 (Aubrun, Langeron, Quesnel, Coriat, & Riou, 2003;Norman, Daley, & Lindsey, 2001;White, 2005). 아편양 제제는 대뇌나 척수 의 아편 수용체에 결합하여 진통효과를 나타내고, NSAIDs는 프로스타글란딘의 생성을 저하시켜 말초 침해 수용체 감작을 억제하여 진통효과를 나타내고 있다 (Rang et al, 2003).…”

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The Effects of Preemptive Analgesia of Morphine and Ketorolac on Postoperative Pain, Cortisol, O2 Saturation and Heart Rate

Seo

Yoon

2008

J Korean Acad Nurs

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Purpose: This study investigated the preemptive analgesic effects of Morphine and Ketorolac on postoperative pain, cortisol, O2 saturation and heart rate for the first 24 hr after abdominal surgery. Methods: Data collection was performed from April 1 to September 30, 2006. Forty patients undergoing a gastrectomy under general anesthesia were randomly allocated to the experimental or control group. The experimental group (20 patients) was administered Morphine and Ketorolac approximately 1 hr prior to skin incision, but the control group (20 patients) was administered Morphine and Ketorolac at peritoneum closure through a patient-controlled analgesia (PCA) pump. Postoperative pain, blood pressure, heart rate, cortisol, O2 saturation, frequency of the PCA button pressed and doses of additional analgesics were observed through post operative 24 hr. Collected data was analyzed using t-test, 2 test, repeated measures ANOVA, and Bonferroni methods. Results: Postoperative pain, cortisol, the frequency of PCA button pressed, and dose of additional analgesics of the experimental group were significantly lower than the control group. There were no statistical differences in blood pressure, heart rate and O2 saturation between the experimental group and control group. Conclusions: We concluded that administration of morphine and ketorolac at 1 hr prior to skin incision resulted in decreasing postoperative pain, but it didn't affect blood pressure, heart rate or O2 saturation for 24 hr after abdominal surgery.

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Acute and Chronic Pain Management

Khelemsky

2012

Anesthesiology and Otolaryngology

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Preemptive Analgesic Effects of Ketorolac in Ankle Fracture Surgery

Abstract: Intravenous 30 mg ketorolac appears to have preemptive analgesic effects in patients undergoing ankle fracture repair. Ketorolac administered before tourniquet inflation prevents postoperative pain being perceived as more intense than preoperative pain.

Cited by 57 publications

References 0 publications

Comparative Evaluation of Pre-Emptive Analgesic Efficacy of Intramuscular Ketorolac Versus Tramadol Following Third Molar Surgery

Comparative Evaluation of Pre-Emptive Analgesic Efficacy of Intramuscular Ketorolac Versus Tramadol Following Third Molar Surgery

The Effects of Preemptive Analgesia of Morphine and Ketorolac on Postoperative Pain, Cortisol, O2 Saturation and Heart Rate

Acute and Chronic Pain Management

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