2008
DOI: 10.4040/jkan.2008.38.5.720
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The Effects of Preemptive Analgesia of Morphine and Ketorolac on Postoperative Pain, Cortisol, O2 Saturation and Heart Rate

Abstract: Purpose: This study investigated the preemptive analgesic effects of Morphine and Ketorolac on postoperative pain, cortisol, O2 saturation and heart rate for the first 24 hr after abdominal surgery. Methods: Data collection was performed from April 1 to September 30, 2006. Forty patients undergoing a gastrectomy under general anesthesia were randomly allocated to the experimental or control group. The experimental group (20 patients) was administered Morphine and Ketorolac approximately 1 hr prior to skin inci… Show more

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Cited by 5 publications
(2 citation statements)
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“…When clinical variables were evaluated in relation to salivary TAS levels, positive correlation was observed between TAS and pain, being the strongest when FRAP assay was used. This finding at least in part could be explained by the fact that pain results in increased cortisol (an endogenous glucocorticoid), which in turn was associated with increased antioxidant capacity of the serum [ 25 , 26 ]. Furthermore, negative and positive correlations between salivary TAS and drainage and xerostomy, respectively, were observed.…”
Section: Discussionmentioning
confidence: 99%
“…When clinical variables were evaluated in relation to salivary TAS levels, positive correlation was observed between TAS and pain, being the strongest when FRAP assay was used. This finding at least in part could be explained by the fact that pain results in increased cortisol (an endogenous glucocorticoid), which in turn was associated with increased antioxidant capacity of the serum [ 25 , 26 ]. Furthermore, negative and positive correlations between salivary TAS and drainage and xerostomy, respectively, were observed.…”
Section: Discussionmentioning
confidence: 99%
“…The main advantage of these agents is that they may form the first-line therapy for pain relief and thus decrease the need of opioids and associated respiratory depressant side effect. 89,90 The effective IV dose is 30 mg every 6 hours. The inhibition of COX-2 by traditional NSAID accounts for the anti-inflammatory effect of the drugs, whereas the inhibition of COX-1 can lead to NSAID toxicity and associated side effects.…”
Section: Strategies For Pain Managements In Obese Osa Patientmentioning
confidence: 99%