Preemptive Epidural Analgesia and Recovery From Radical Prostatectomy. A Randomized Controlled Trial

Gottschalk, Allan; Smith, David S.; Jobes, David R.; Kennedy, Sean K.; Lally, Sara E.; Noble, Vicki E.; Grugan, K.F.; Seifert, Harry A.; Cheung, Albert T.; Malkowicz, S. Bruce; Gutsche, Brett B.; Wein, Alan J.

doi:10.1016/s0022-5347(01)62657-0

Cited by 28 publications

(42 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3][4] However, the results of the intraoperative use of TEA in combination with general anesthesia are still controversial with respect to a reduction of postoperative pain perception or postoperative analgesic consumption. [5][6][7][8][9][10] This can be explained in part by the variety of types and sites of surgery, 11 or by the presence or absence of pain before surgery. 12 In a recently published review Moiniche et al pointed out that preemptive continuous epidural treatment extending into the postoperative period might have an improved capacity to reduce nociceptive input and thereby central neuroplasticity caused not only by incision and ongoing surgery but also by postsurgical inflammation.…”

Section: Me Et Th Ho Od Ds S:mentioning

confidence: 99%

“…This might explain the preemptive analgesic effect described for radical prostatectomy. 6,14 In contrast to the above-mentioned single drug applications, Rockemann et al were able to reduce postoperative analgesic consumption in their study using a multimodal pre-surgical analgesic approach for major abdominal surgery. 15 Nevertheless, the use of nonsteroidal anti-inflammatory drugs should be evaluated critically, in the presence of potential major bleeding.…”

Section: Side Effectsmentioning

confidence: 99%

See 1 more Smart Citation

Pre- and intraoperative epidural ropivacaine have no early preemptive analgesic effect in major gynecological tumour surgery

Burmeister

Gottschalk

Freitag

et al. 2003

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

P Pu ur rp po os se e: : Thoracic epidural analgesia (TEA) is an established technique for postoperative pain relief after major abdominal surgery. However it is still under discussion whether pre-incisional TEA can reduce postoperative pain perception or postoperative analgesic consumption. M Me et th ho od ds s: :The present prospective, randomized, double-blind study was performed to investigate the effects of intra-and postoperative TEA vs only postoperative TEA using ropivacaine 0.375% in 30 women scheduled for major abdominal tumour surgery. Prior to induction of general anesthesia patients received an epidural bolus of 10 mL saline in Group I (GI) and 10 mL ropivacaine 0.375% in Group II (GII) followed by an infusion of 6 mL·hr -1 of the respective solution during surgery. Postoperatively all patients received an epidural infusion of 6 mL·hr -1 ropivacaine 0.375% during 24 hr followed by patient controlled epidural analgesia for the next 72 hr. Operative data, dynamic pain scores, consumption of local anesthetics and standardized supplemental analgesics were analyzed. R Re es su ul lt ts s: : No difference was seen between groups with respect to the amount of required postoperative local anesthetics and supplemental analgesics, pain scores and side effects during the first 96 hr following surgery except a reduction of intraoperative sufentanil consumption (GI: 143.2 ± 52.6 vs GII: 73.3 ± 32.6 µg, P < 0.001).C Co on nc cl lu us si io on n: : Intraoperative TEA with ropivacaine 0.375% did not significantly reduce the amount of analgesics required after major abdominal gynecological tumour surgery. (GI : 143,2 ± 52,6 vs GII : 73,3 ± 32,6 µg, P < 0,001 Objectif : L'analgésie péridurale thoracique (APT) est

show abstract

Section: Me Et Th Ho Od Ds S:mentioning

confidence: 99%

Section: Side Effectsmentioning

confidence: 99%

Pre- and intraoperative epidural ropivacaine have no early preemptive analgesic effect in major gynecological tumour surgery

Burmeister

Gottschalk

Freitag

et al. 2003

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

show abstract

“…By influencing the many domains assessed by quality of recovery, postoperative pain may have a general detrimental effect on quality of recovery [20]. Therefore, postoperative pain and relief affects both medical resource use and patients' ability to resume the normal activities of their lives after discharge from the hospital to home [21]. Even though there is sufficient relief with conventional analgesics, postoperative pain interferes with patients' ability to sleep, walk, and participate in other activities.…”

Section: Analgesia the Relief From Painmentioning

confidence: 99%

Introduction to Pain, Religion and Analgesia

Ghosh¹

2012

Pain in Perspective

View full text Add to dashboard Cite

“…Proper infiltration of the periosteum of the mastoid cortex needs a mention apart from regular subcutaneous infiltration. One of the reasons for persisting post operative pain even after local anaesthetic infiltration is failure to infiltrate the periosteum [27].…”

Section: Pain Scorementioning

confidence: 99%

Is Lidocaine Infiltration Really Necessary in Micro Ear Surgeries performed Under General Anaesthesia?

Senthil

Samuel

Ramachandran

2011

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

To study the role of infiltrating 2% Lidocaine in Micro ear surgeries performed under general anaesthesia. To measure the impact of infiltration of 2% Lidocaine in post operative pain relief and per operative bleeding. A Double blinded, Prospective randomized comparative study was conducted in a tertiary care referral centre. A total of 30 patients planned for micro ear surgeries under general anaesthesia (Tympanoplasty and Cortical mastoidectomy) for CSOM tubotympanic disease were selected and divided into two groups randomly by the chief senior consultant. Group A patients received local infiltration of 2% Lidocaine with one in 200,000 adrenaline and Group B patients received infiltration of one in 200,000 adrenaline in distilled water alone. Operating surgeon assessed the bleeding in the surgical field using Boezaart's grading system. Post operative pain was assessed using a visual analog scale. Pain scores of these patients were assessed in the 1st, 4 and 24th h post operatively and recorded. The mean post operative pain score in the 1st h for the patients in Group A was 0.93 and for patients in Group B was two. The difference in the pain scores between the two groups was significant (P \ 0.02).The difference in the mean post operative pain scores between the two groups in the 4 and 24th h were not significant (P \ 0.1).Per operatively, grade III bleeding was present in 73% of patients in group B and only 33% of patients had grade III bleeding in group A. Infiltration of 2% Lidocaine has a significant impact over the grade of bleeding in the operative field and also on 1st h post operative pain relief. It did not have a significant influence on the pain relief in the 4 and 24th h post operatively.

show abstract

Preemptive Epidural Analgesia and Recovery From Radical Prostatectomy. A Randomized Controlled Trial

Cited by 28 publications

References 40 publications

Pre- and intraoperative epidural ropivacaine have no early preemptive analgesic effect in major gynecological tumour surgery

Pre- and intraoperative epidural ropivacaine have no early preemptive analgesic effect in major gynecological tumour surgery

Introduction to Pain, Religion and Analgesia

Is Lidocaine Infiltration Really Necessary in Micro Ear Surgeries performed Under General Anaesthesia?

Contact Info

Product

Resources

About