Prefabrication of an axial bio-synthetic flap for circumferential tracheal defect reconstruction

Lykoudis, Efstathios G.; Tsoutsos, Dimosthenis; Papalois, Apostolos; Frangia, Konstantina; Stamatopoulos, Constantinos N.; Ioannovich, John

doi:10.1054/bjps.2000.3382

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…Cadavas [3] prefabricated an axial composite flap consisting of skin, cartilage and mucosa, which provides epithelial lining, but the method is complicated and requires multiple procedures. Lykoudis et al [2] defined an axial prefabricated flap containing an epithelial lining reinforced with synthetic materials but since they did not perform anastomosis, the success of the flap could not be evaluated without the use of stent.…”

Section: Dicussionmentioning

confidence: 99%

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Circumferential trachea reconstruction with a prefabricated axial bio-synthetic flap: experimental study

Okumus¹,

Çizmeci²,

Kabakas³

et al. 2005

International Journal of Pediatric Otorhinolaryngology

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Section: Dicussionmentioning

confidence: 99%

“…Primary endto-end anastomosis without excessive tension is the desired procedure [1]. However, it can only work on defects no longer than 5-6 cm [2]. Circumferential defects longer than 5-6 cm or more than half of the total tracheal length can only be reconstructed by using local or distant tissues [3,4] or by synthetic grafts.…”

Section: Introductionmentioning

confidence: 99%

Circumferential trachea reconstruction with a prefabricated axial bio-synthetic flap: experimental study

Okumus¹,

Çizmeci²,

Kabakas³

et al. 2005

International Journal of Pediatric Otorhinolaryngology

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Extended lateral thoracic fasciocutaneous biosynthetic flap for reconstruction of full-thickness partial external ear defects: an experimental study

Kuvat

Taşkın

Yücebaş

et al. 2016

Eur Arch Otorhinolaryngol

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External ear reconstruction is a controversial topic in reconstructive plastic surgery. Here, we prepared a pedicled biosynthetic flap for full-thickness, partial ear defects in rabbits. We operated on six adult female New Zealand rabbits weighing 3-4 kg. The dimensions of the lateral thoracic fasciocutaneous flap were 7 × 6 cm. The flap was elevated based on one of the bilaterally located internal thoracic arteries, which were dissected proximally. The pedicled flap was folded in two, and polypropylene mesh was sandwiched in the middle. The flap was adapted to a defect of 3.5 × 3 cm in diameter. In fact, the defect was created before elevation of the flap. Rabbits were followed up for 4 weeks, at the end of which they were killed and their ears were evaluated histopathologically. The survival rate of the rabbits was 100 %. All pedicled biosynthetic flaps were viable, but one showed partial (20 %) necrosis (1/6) and one was partially detached (1/6). Macroscopic (color, thickness, texture) and histological (polymorphonuclear leukocyte invasion in the skin, subcutaneous tissue, and at the junction between the polypropylene mesh and the flap) features of the flap were compared to the ipsilateral ear. A new technique was developed for partial external ear reconstruction with sufficient inner skeletal support and outer skin lining. Level of evidence Level NA.

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A rational tissue engineering strategy based on three-dimensional (3D) printing for extensive circumferential tracheal reconstruction

Park

Nam

et al. 2018

Biomaterials

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Prefabrication of an axial bio-synthetic flap for circumferential tracheal defect reconstruction

Cited by 4 publications

References 28 publications

Circumferential trachea reconstruction with a prefabricated axial bio-synthetic flap: experimental study

Circumferential trachea reconstruction with a prefabricated axial bio-synthetic flap: experimental study

Extended lateral thoracic fasciocutaneous biosynthetic flap for reconstruction of full-thickness partial external ear defects: an experimental study

A rational tissue engineering strategy based on three-dimensional (3D) printing for extensive circumferential tracheal reconstruction

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