Preface

Age‐related changes in regional brain mitochondria from Fischer 344 rats

“…Similarly, we cannot rule out sex-associated differences in brain mitochondrial aging. Because male rats have a higher incidence of age-related pathophysiology that might adversely confound our measurements (Maeda et al, 1985;Fox et al, 2002), the absence of central nervous system (CNS) mitochondria from males at the oldest age studied could have biased our data in the direction of no change. We did, however, see mild deterioration above 32 months.…”

Clinical veterinarian’s perspective of non-human primate (NHP) use in drug safety studies

“…Fighting in cynomolgus monkeys can be sudden, even in familiar or established pairs. As the animals age and they reach sexual maturity (females at approximately 46 months-of-age and males at approximately 42-60 monthsof-age) (Fox et al, 2002), fighting may be more of a concern. These animals are generally larger in size and can cause substantially more damage as their canine teeth are often fully grown.…”

Naturally occurring infections in non-human primates (NHP) and immunotoxicity implications: Discussion sessions

“…Commonly-used treatments include supportive care, enrofloxacin, ampicillin, amoxicillin, and metronidazole. Treatment for some species, such as Salmonella spp., may be a concern as animals may become carriers, and multidrug resistance can be common (Fox et al, 2002;Taylor, 2010).…”

“…Presentation may consist of epistaxis (VandeWoude and Luzarraga, 1991), upper respiratory disease (nasal discharge, congestion), meningitis, cough, and/or dyspnea, and the infections may be treated with enrofloxacin, penicillin, and/or cephalosporins (Fox et al, 2002;Taylor, 2010). Other bacterial infections such as skin abscesses secondary to trauma are commonly caused by Staphylococcus and Streptococcus spp.…”

“…Common respiratory pathogens in monkeys include Streptococcus pneumoniae, Klebsiella pneumoniae, and Moraxella catarrhalis (VandeWoude and Luzarraga, 1991;Fox et al, 2002). Presentation may consist of epistaxis (VandeWoude and Luzarraga, 1991), upper respiratory disease (nasal discharge, congestion), meningitis, cough, and/or dyspnea, and the infections may be treated with enrofloxacin, penicillin, and/or cephalosporins (Fox et al, 2002;Taylor, 2010).…”