Preface

Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv

doi:10.1016/b978-1-4160-3123-9.50003-6

Cited by 647 publications

(1,251 citation statements)

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“…T hücreleri antijeni yüzeylerindeki Human-Lökosit antijeni (HLA) molekülleri ile tanıyarak aktive olur. 34 Aktive olmuş T hücreleri ürettikleri sitokinlere göre iki ana tipteki yardımcı T hücreleridir. Bu sitokinler immün yanıtın başlangıcında ve sonlanmasında yardımcı rol oynarlar.…”

Section: İmmunopatogenezunclassified

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An industrial risk: Beryllium

Çaylak

Aytekin²

2012

J Clin Exp Invest

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Beryllium is a vocational disease factor and beryllium exposure can potentially lead to Chronic Beryllium Disease (CBD) in 2-6 % of workers. While acute lymphocytic pneumonia occurred in individuals who were exposed to high doses of beryllium, low dose exposure to beryllium followed by a long subclinical period can cause CBD characterized with chronic granulomatosis. It has been observed that varying amounts of beryllium exposure are necessary to produce symptoms of CBD or beryllium sensitization (BeS). Genetic differences between patients may be the underlying cause of these dose-effects and further study of the differences in patients exposed to beryllium may lead to earlier diagnosis and the identification of biomarkers of CBD. In this review, it is summarized the general properties of beryllium exposure, the immunopathogenesis and genetic differences of beryllium-induced diseases, genotoxicity and the carcinogenic effects of beryllium.

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Section: İmmunopatogenezunclassified

“…34 T hücreleri yabancı antijeni kompleks bir şekilde iş-ler. Yüzeylerinde yer alan 8 ila 25 aminoasit uzunluğunda HLA molekülünün bağlandığı bir peptit ligand içeren T hücre reseptörleri bulunur.…”

Section: Genetikunclassified

An industrial risk: Beryllium

Çaylak

Aytekin²

2012

J Clin Exp Invest

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“…They are the only cells that can recognize and distinguish between antigenic determinants, which give them characteristics of an acquired immune response, that is, the specificity of a memory (Abbas et al, 2003). These cells have largely been used in studies of apoptosis due to the striking importance of their apoptotic death during immune system maturation and some diseases (Rathmell and Thomson, 2002).…”

Section: Introductionmentioning

confidence: 99%

Light microscope observation of circulating human lymphocytes cultured in vitro

Oliveira

Dolder

Genari

2010

Braz. arch. biol. technol.

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“…CIK cells also secrete high levels of IL-2 via overexpression. IL-2 is an essential factor for growth, survival, and differentiation of T lymphocytes (Abbas et al, 2012;Malek and Bayer, 2004) including NK-T cells. Acting as an autocrine cytokine, IL-2 plays an important role in the generation and proliferation of effector CIK cells.…”

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confidence: 99%

“…IFN-, which is a cytokine employed during both innate and adaptive immune responses, produces downstream effects such as increased presentation of class I and II MHC molecules, activation of macrophages, differentiation of naive T cells into TH1 cells, and induction of B cell isotype switching (Abbas et al, 2012;Aittomäki, 2003). TNF- is a pro-inflammatory cytokine that induces fever and inflammatory responses, apoptosis, and tumor cell necrosis (Wajant et al, 2003).…”

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Culture and differentiation of cytokine-induced killer cells from umbilical cord blood-derived mononuclear cells

Duong

et al. 2016

Biomed Res Ther

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Abstract-Cytokine-induced killer cells (CIK) are cytotoxic T cells, which have both NK and T cell properties. These cells are characterized by potent, non-MHC-restricted cytotoxicity and reduced alloreactivity, which make them appealing for use in adoptive immunotherapy of cancer and virus infections. In this study, CIK cells were generated by stimulating umbilical cord blood-derived mononuclear cells (UCB-MNCs) with interferon-gamma (IFN-) on day 0. Anti-CD3 antibody and interleukin-2 (IL-2) were added after 24 hours at four different experimental concentration combinations in order to identify the optimal cytokine amounts for CIK cell proliferation. Cells were collected at four time points over a 21-day period (day 0, 7, 14, 21) for analysis of cell marker presentation using flow cytometry, as well as transcription-level cytokine production using RT-PCR. The results showed that in the 21-day culture, the average final expansion levels of CD3 + CD56 + CIK cell were in the range of hundredfold, accounted for 26% in the bulk culture. Most important, these cells strongly expressed granzyme B (80.87%), a potent factor involved in cell-mediated cytotoxicity. These CIK cells also transcriptionally overexpressed the three cytokine genes that produce IFN-, tumor necrosis factor-alpha (TNF-), and IL-2; these are key for immune cell mobilization against tumors as well as foreign pathogens. Our research establishes an effective cytokine concentration and time protocol for use in generation of CIK cells from UCB-MNCs, potentiating greater applications of CIK cell-adoptive immunotherapy in both research and clinical settings. Thus, the 3 rd and 4 th experimental conditions both stimulated CIK cell differentiation with 50 ng/ml of anti-CD3 antibody, but with IL-2 concentrations of 500 U/ml and 1000 U/ml, respectively.

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Preface

Cited by 647 publications

References 0 publications

An industrial risk: Beryllium

An industrial risk: Beryllium

Light microscope observation of circulating human lymphocytes cultured in vitro

Culture and differentiation of cytokine-induced killer cells from umbilical cord blood-derived mononuclear cells

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