Preference on Cash-Choice Task Predicts Externalizing Outcomes in 17-Year-Olds

Sparks, Jordan C.; Isen, Joshua D.; Iacono, William G.

doi:10.1007/s10519-013-9638-2

Cited by 23 publications

(30 citation statements)

References 46 publications

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“…Given that this association trended in the opposite direction in females, the interaction of sex (females = 0, males = 1) with substance use group was significant ( b = −0.47, p = .02). As expected on the basis of previous work (Sparks et al, 2014), Cash Choice showed robust associations with disinhibitory psychopathology and self-reported impulsivity.…”

Section: Resultssupporting

confidence: 89%

“…Heritability of HDD was in the 40–50% range, which is similar to estimates obtained from the Cash Choice task (Sparks et al, 2014). Although HDD and Cash Choice reveal similar broad-sense heritability estimates, the underlying genetic mechanisms may differ.…”

Section: Discussionsupporting

confidence: 83%

“…We found that non-additive genetic factors were likely responsible for twin resemblance in HDD, whereas genetic influences on Cash Choice appear to be additive in nature. This is illustrated by the fact that the DZ twin concordance for Cash Choice outcome is moderate in magnitude ( r = 0.35; Sparks et al, 2014), approaching that of MZ twins, and suggestive of family-wide environmental influences. In contrast, the DZ correlation for HDD is small ( r = 0.14), but this should be interpreted with caution, as it was based on fewer than 100 twin pairs.…”

Section: Discussionmentioning

confidence: 99%

“…At the younger assessment wave, we administered a computerized DD task involving hypothetical monetary scenarios. At the follow-up assessment (approximately three years later), we administered a one-shot “Cash Choice” paradigm that utilizes real-world cash incentives (Sparks, Isen, & Iacono, 2014). The delayed reward amount ($10) was constant across the two tasks.…”

Section: Present Studymentioning

confidence: 99%

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Predictive validity of delay discounting behavior in adolescence: A longitudinal twin study.

Isen

Sparks

Iacono

2014

Experimental and Clinical Psychopharmacology

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A standard assumption in the delay discounting literature is that individuals who exhibit steeper discounting of hypothetical rewards also experience greater difficulty deferring gratification to real-world rewards. There is ample cross-sectional evidence that delay discounting paradigms reflect a variety of maladaptive psychosocial outcomes, including substance use pathology. We sought to determine whether a computerized assessment of hypothetical delay discounting (HDD) taps into behavioral impulsivity in a community sample of adolescent twins (N = 675). Using a longitudinal design, we hypothesized that greater HDD at age 14–15 predicts real-world impulsive choices and risk for substance use disorders in late adolescence. We also examined the genetic and environmental structure of HDD performance. Individual differences in HDD behavior showed moderate heritability, and were prospectively associated with real-world temporal discounting at age 17–18. Contrary to expectations, HDD was not consistently related to substance use or trait impulsivity. Although a significant association between HDD behavior and past substance use emerged in males, this effect was mediated by cognitive ability. In both sexes, HDD failed to predict a comprehensive index of substance use problems and behavioral disinhibition in late adolescence. In sum, we present some of the first evidence that HDD performance is heritable and predictive of real-world temporal discounting of rewards. Nevertheless, HDD might not serve as a valid marker of substance use disorder risk in younger adolescents, particularly females.

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Section: Resultssupporting

confidence: 89%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Present Studymentioning

confidence: 99%

See 2 more Smart Citations

Predictive validity of delay discounting behavior in adolescence: A longitudinal twin study.

Isen

Sparks

Iacono

2014

Experimental and Clinical Psychopharmacology

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“…The first study assessed early adolescent twins and found evidence of genetic influences at both age 12 and 14 (30 and 51%, respectively) (Anokhin et al 2011). The second study comprised 17-year-old twins from the Minnesota Twin Family Enrichment study and found that discounting had a quite similar heritability rate to the previous study (51%) (Sparks et al 2014). In the same sample, a third study examined the heritability of a different delay discounting phenotype and found similar rates of heritability (47%) (Isen et al 2014).…”

Section: Introductionmentioning

confidence: 78%

Genetic influences on delay discounting in smokers: examination of a priori candidates and exploration of dopamine-related haplotypes

et al. 2015

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RATIONALE Delay discounting is a behavioral economic index of impulsivity that reflects a person’s relative preference for small immediate rewards versus larger delayed rewards. Elevated delay discounting is robustly linked to addictive disorders and has been increasingly investigated as a viable endophenotype for genetic influences on addiction. OBJECTIVE To examine associations between delay discounting and two a priori loci, rs4680 in COMT and rs1800497 in ANKK1, and three exploratory haplotypes proximal to rs1800497 in a sample of daily smokers. METHODS Participants were 713 (60.2% male) daily smokers of European ancestry who completed a delay discounting assessment and provided a DNA sample. RESULTS Significant associations were detected between greater discounting of medium magnitude rewards (~$55) and the G allele of rs4680 as well as the T allele of rs1800497. Exploratory haplotype analyses identified two haplotypes (rs1160467/rs1800497; rs6277/rs1079597) significantly associated with delay discounting rates. However, the rs1160467/rs1800497 haplotype associations appeared to be entirely attributable to variation in rs1800497, suggesting that the association of rs1800497 with discounting is best understood at the individual SNP level. Similarly, the rs6277/rs1079597 haplotype findings suggested the association was specific to rs1079597. CONCLUSIONS This study provides further evidence that rs4680 and rs1800497 genotype are significantly associated with delay discounting preferences and does so among smokers for the first time. The study also provides evidence of specificity for the rs1800497 association, and identifies a novel locus, rs1079597, as a genetic contributor to higher delay discounting rates.

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Associations Between Delay Discounting and Risk‐Related Behaviors, Traits, Attitudes, and Outcomes

Mishra

Lalumière

2016

Behavioral Decision Making

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Delay discounting—preference for immediate, smaller rewards over distal, larger rewards—has been argued to be part of the “generality of deviance”, which describes the co‐occurrence of various forms of impulsive and risky behaviors among individuals. Some studies have linked laboratory‐measured delay discounting to behaviors, traits, attitudes, and outcomes associated with risk, but these associations have been inconsistent. Furthermore, many of these studies have been conducted with exclusively undergraduate samples, or in samples offering low statistical power. In a large community sample (n = 328) diverse in age and socioeconomic status, we examined associations between two measures of behavioral delay discounting (single‐shot and canonical k‐parameter estimation) and behavioral risk‐taking, personality traits associated with risk, domain‐specific risk attitudes, gambling and problem gambling, antisocial behavior, and criminal outcomes. In addition, we explored whether a novel response time latency measure of delay discounting explained variance in these risk‐related outcomes. Results indicated that behavioral delay discounting was consistently associated with all variables related to impulse control: high trait impulsivity, low trait self‐control, risk‐averse attitudes toward financial investment, risk‐prone attitudes toward gambling and health/safety risks, gambling and problem gambling, antisocial conduct, and criminal outcomes. Latency‐measured delay discounting was inconsistently associated with behavioral delay discounting and risk‐related measures. Together, results suggest that delay discounting is associated with poor impulse control consistent with a generality of deviance account. Copyright © 2016 John Wiley & Sons, Ltd.

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Preference on Cash-Choice Task Predicts Externalizing Outcomes in 17-Year-Olds

Cited by 23 publications

References 46 publications

Predictive validity of delay discounting behavior in adolescence: A longitudinal twin study.

Predictive validity of delay discounting behavior in adolescence: A longitudinal twin study.

Genetic influences on delay discounting in smokers: examination of a priori candidates and exploration of dopamine-related haplotypes

Associations Between Delay Discounting and Risk‐Related Behaviors, Traits, Attitudes, and Outcomes

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