Preferential Fat Deposition in Subcutaneous Versus Visceral Depots Is Associated with Insulin Sensitivity

McLaughlin, Tracey; Lamendola, Cindy; Liu, Alice; Abbasi, Fahim

doi:10.1210/jc.2011-0615

Cited by 405 publications

(295 citation statements)

References 23 publications

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“…In addition, our analysis pertains to people from a wide range of backgrounds and origins, reflecting that the development of diabetes is not origin specific. Second, although they did not compromise the outcome definition, measurements of waist circumference or specific fat compartments (27,28), circulating insulin and Cpeptide, were not obtained in this study, limiting our ability to more directly assess adiposity and insulin resistance. Finally, the analysis was conducted only in men, thereby limiting the generalization of the results to women.…”

Section: Resultsmentioning

confidence: 93%

Diabetes Risk Among Overweight and Obese Metabolically Healthy Young Adults

et al. 2014

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OBJECTIVETo determine diabetes incidence over time among obese young adults without metabolic risk factors. RESEARCH DESIGN AND METHODSIncident diabetes during a median follow-up of 6.1 years was assessed among 33,939 young men (mean age 30.9 6 5.2 years) of the Metabolic, Lifestyle and Nutrition Assessment in Young Adults cohort who were stratified for BMI and the number of metabolic abnormalities (based on the Adult Treatment Panel-III). Metabolically healthy (MH) obesity was defined as BMI ‡30 kg/m 2 in the presence of normoglycemia, normal blood pressure, and normal levels of fasting triglyceride and HDL-cholesterol levels (n = 631). RESULTSA total of 734 new cases of diabetes were diagnosed during 210,282 person-years of follow-up. The incidence rate of diabetes among participants with no metabolic risk factors was 1.15, 2.10, and 4.34 cases per 1,000 person-years among lean, overweight, and obese participants, respectively. In a multivariable model adjusted for age, region of origin, family history of diabetes, physical activity, fasting plasma glucose, triglyceride level, HDL-cholesterol, systolic blood pressure, and white blood cell count, a higher diabetes risk was observed among MH-overweight (hazard ratio [HR] 1.89 [95% CI 1.25-2.86]; P < 0.001) and MH-obese (HR 3.88 [95% CI 1.94-7.77]; P < 0.001) compared with MH-normal weight subjects. There was no interaction between BMI and the number of metabolic abnormalities at enrollment in predicting diabetes risk. CONCLUSIONSHealthy metabolic profile and the absence of diabetes risk factors do not protect young adults from incident diabetes associated with overweight and obesity.Heterogeneity in the metabolic risk status of individuals with normal weight (NW), overweight, or obesity raised the hypothesis that metabolically healthy (MH)-obese individuals have no additional metabolic risk (1-3). However, there is conflicting evidence regarding the metabolic course of this subpopulation. Adjusted diabetes risk, for example, was reported to be unchanged (1,3), 4-fold higher (4), or 13-fold higher in MH-obese compared with MH-NW individuals (5).While the definition of healthy obesity suffers from inconsistency (6,7), the prevailing defining criteria of MH in most studies assessing diabetes risk include individuals with a BMI $30 kg/m 2 with one (1,4) or even two (3,5,7) metabolic

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Section: Resultsmentioning

confidence: 93%

Diabetes Risk Among Overweight and Obese Metabolically Healthy Young Adults

et al. 2014

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“…As previously reported 37) , the present study demonstrated that there was an increase in EPA could aggravate vascular inflammation, plaque instability, and neovascularization 23) . In general, AVAT has been reported to be a major contributor to metabolic risk 24,25) , whereas SAT has been suggested to play a protective role 26) .…”

Section: Discussionmentioning

confidence: 99%

Effects of Eicosapentaenoic Acid Treatment on Epicardial and Abdominal Visceral Adipose Tissue Volumes in Patients with Coronary Artery Disease

Sato

Kameyama

Ohori³

et al. 2014

JAT

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Aim: Epicardial adipose tissue (EAT) is a pathogenic fat depot that may be associated with coronary atherosclerosis and cardiovascular events. Because eicosapentaenoic acid (EPA) has been reported to exert cardiovascular protective effects, we aimed to assess the effects of EPA on the volume of visceral adipose tissue, including EAT and abdominal visceral adipose tissue (AVAT), using multislice computed tomography (CT). A similar negative correlation in these parameters was also observed for the EAT volume. Conclusions: Oral intake of purified EPA appears to be associated with reductions in EAT and AVAT volumes.

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“…However, it is not the most interesting tissue, because SAT correlates less strongly with metabolic risks factors than VAT, as has been demonstrated in the Framingham heart study (Fox et al, 2007). In addition, VAT has been shown to correlate with insulin resistance, whereas SAT is protective against insulin resistance, which has been shown by analysis of VAT and SAT in insulin-resistant and insulinsensitive obese subjects (women and men) by adjusting the relation between SAT and insulin for BMI and VAT (McLaughlin et al, 2011). In our study, insulin and HOMA-IR were positively correlated to VAT, but not to SAT, corroborating the literature observations.…”

Section: Correlations With Bfdmentioning

confidence: 96%

Gender-Dependent Associations of Metabolite Profiles and Body Fat Distribution in a Healthy Population with Central Obesity: Towards Metabolomics Diagnostics

Szymańska

Bouwman

Strassburg

et al. 2012

OMICS: A Journal of Integrative Biology

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Gender-dependent associations of metabolite profiles and body fat distribution in a healthy population with central obesity: towards metabolomics diagnostics Szymanska, E.; Bouwman, J.; Strassburg, K.; Vervoort, J.; Kangas, A.J.; Soininen, P.; AlaKorpela, M.; Westerhuis, J.A.; van Duynhoven, J.P.M.; Mela, D.J.; Macdonald, I.A.; Vreeken, R.J.; Smilde, A.K.; Jacobs, D.M. Published in: Omics DOI:10.1089/omi.2012.0062 Link to publication Citation for published version (APA):Szymaska, E., Bouwman, J., Strassburg, K., Vervoort, J., Kangas, A. J., Soininen, P., ... Jacobs, D. M. (2012). Gender-dependent associations of metabolite profiles and body fat distribution in a healthy population with central obesity: towards metabolomics diagnostics. Omics, 16(12), 652-667. DOI: 10.1089/omi.2012.0062 General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. AbstractObesity is a risk factor for cardiovascular diseases and type 2 diabetes especially when the fat is accumulated to central depots. Novel biomarkers are crucial to develop diagnostics for obesity and related metabolic disorders. We evaluated the associations between metabolite profiles (136 lipid components, 12 lipoprotein subclasses, 17 low-molecular-weight metabolites, 12 clinical markers) and 28 phenotype parameters (including different body fat distribution parameters such as android (A), gynoid (G), abdominal visceral (VAT), subcutaneous (SAT) fat) in 215 plasma/serum samples from healthy overweight men (n = 32) and women (n = 83) with central obesity.(Partial) correlation analysis and partial least squares (PLS) regression analysis showed that only specific metabolites were associated to A:G ratio, VAT, and SAT, respectively. These association patterns were gender dependent. For example, insulin, cholesterol, VLDL, and certain triacylglycerols (TG 54:1-3) correlated to VAT in women, while in men VAT was associated with TG 50:1-5, TG 55:1, phosphatidylcholine (PC 32:0), and VLDL ((X)L). Moreover, multiple regression analysis revealed that waist circumference and total fat were sufficient to predict VAT and SAT in women. In contrast, only VAT but not SAT could be predicted in men and only when plasma metabolites were included, with PC 32:0 being most strongly associated with VAT. These findings collectively highlight the p...

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Preferential Fat Deposition in Subcutaneous Versus Visceral Depots Is Associated with Insulin Sensitivity

Cited by 405 publications

References 23 publications

Diabetes Risk Among Overweight and Obese Metabolically Healthy Young Adults

Diabetes Risk Among Overweight and Obese Metabolically Healthy Young Adults

Effects of Eicosapentaenoic Acid Treatment on Epicardial and Abdominal Visceral Adipose Tissue Volumes in Patients with Coronary Artery Disease

Gender-Dependent Associations of Metabolite Profiles and Body Fat Distribution in a Healthy Population with Central Obesity: Towards Metabolomics Diagnostics

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