Prefoldin: A Nano Actuator for Carrying the Various Size Nano Drugs

Ghaffari, Ali; Shokuhfar, Ali; Ghasemi, Reza Hasanzadeh

doi:10.1166/jctn.2011.1929

Cited by 10 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can serve as the drug carrier to improve the sensibility and specificity of disease detection and diagnosis, and serve as the solid carrier to construct electrochemical sensor with proteins. [4][5][6] However, its security issues are attracting worldwide attention. Because of its own physicochemical properties, the nano-materials can enter into the body through respiratory tract inhalation, gastrointestinal tract absorption, penetration of the skin tissue, injection and other ways, especially through the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

Influence of Nano-Manganese Dioxide on Rat Spatial Learning and Memory Function and Its Injury for Rat Ventral Midbrain

Zhang¹,

Hou²,

Li³

et al. 2015

Jnl of Comp & Theo Nano

View full text Add to dashboard Cite

Objective: To explore the influence of nano-manganese dioxide on the rat spatial learning and memory function and its injury for rat ventral midbrain. Methods: Under cerebral stereotaxis, the physiological saline was injected into the brains of rats in the control group, while nano-manganese dioxide was injected into the brains of rats in the experimental groups. Morris water maze tests were performed one, two, three and four weeks after the injection, respectively. The ventral brain tissues of rats in each group were separated, and RT-PCR and Western blot were used to detect the expression changes of tyrosine hydroxylase, glial fibrillary acidic protein and inducible nitric oxide synthase in the tissues. Results: Intracerebral injection of nano-manganese dioxide made the rats swim slower in Morris water maze test. Two and three weeks after the injection, the time of finding the platform for rats and the latent period became significantly longer. The search platform strategy changed from tendency type and stochastic type to tendency type and edge type. The analysis results of RT-PCR and Western blot showed that the tyrosine hydroxylase expression level in the rat ventral brain tissues decreased and the expression levels of glial fibrillary acidic protein and inducible nitric oxide synthase increased obviously (P < 0 05). Conclusion: Intracerebral injection of nano-manganese dioxide can affect the rat spatial learning and memory function, cause the destruction of dopaminergic neuron in the rat midbrain, the decrease of tyrosine hydroxylase expression level and the increase of the expression levels of glial fibrillary acidic protein and inducible nitric oxide synthase, and have certain injury for ventral midbrain.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of Nano-Manganese Dioxide on Rat Spatial Learning and Memory Function and Its Injury for Rat Ventral Midbrain

Zhang¹,

Hou²,

Li³

et al. 2015

Jnl of Comp & Theo Nano

View full text Add to dashboard Cite

show abstract

“…With further research, [69][70][71][72] it was discovered that PFDN has the ability to act as a nano-component in bio-nano-robots, and was gradually designed as a prefoldin nano-actuator (PNA) to act as a drug delivery tool and carrier. 4,69,73,74 The six tentacles of the PNA make it very flexible. When the temperature and pH of the environmental medium are changed, the overall structure and space size of the PNA are significantly affected, and the combination and release of nano-cargo are controlled.…”

Section: Prefoldin and Nanotechnology Prefoldin Can Be Used As A Nanomentioning

confidence: 99%

<p>The Role of Prefoldin and Its Subunits in Tumors and Their Application Prospects in Nanomedicine</p>

Mo¹,

Zhao²,

Tian³

et al. 2020

CMAR

View full text Add to dashboard Cite

Prefoldin (PFDN) is a hexameric chaperone complex that is widely found in eukaryotes and archaea and consists of six different subunits (PFDN1-6). Its main function is to transfer actin and tubulin monomers to the eukaryotic cell cytoplasmic chaperone protein (c-CPN) specific binding during the assembly of the cytoskeleton, to stabilize the newly synthesized peptides so that they can be folded correctly. The current study found that each subunit of PFDN has different functions, which are closely related to the occurrence, development and prognosis of tumors. However, the best characteristics of each subunit have not been fully affirmed. The connection between research and tumors can change the understanding of PFDN and further extend its potential prognostic role and structural function to cancer research and clinical practice. This article mainly reviews the role of canonical PFDN and its subunits in tumors and other diseases, and discusses the potential prospects of the unique structure and function of PFDN in nanomedicine.

show abstract

“…The mutant PNA for creating attractive force between PNA and nano cargo at neutral pH and repulsive force at pH 3. and engineering studies. This interesting properties cause, Archaeal Prefoldin is used to create a novel nano actuator that can be used for nanoscale manipulation [18][19][20][21].…”

Section: Prefoldin Nano Actuator (Pna)mentioning

confidence: 99%

“…Conformational flexibility of PNA has been studied in detail [18]. Temperature and pH as two control parameters have been used to control of cavity of PNA [22].…”

Section: Prefoldin Nano Actuator (Pna)mentioning

confidence: 99%