Prefrontal cortex and hippocampus in posttraumatic functional recovery: Spatial delayed alternation by rats subjected to transection of the fimbria–fornix and/or ablation of the prefrontal cortex

Prefrontal cortex and hippocampus in behavioural flexibility and posttraumatic functional recovery: Reversal learning and set-shifting in rats

“…We have previously argued [Mogensen, 2011a[Mogensen, , 2011b[Mogensen, , 2012a[Mogensen, , 2012b[Mogensen, , 2014[Mogensen, , 2015Mogensen and Malá, 2009] that posttraumatically, the neural substrate of task mediation is reorganized in such ways that within the preserved regions of the brain a given structure can demonstrate either an increased or decreased contribution to the mediation of the task. In support of that, we have reported findings suggesting that during posttraumatic recovery of task performance on certain tasks, there is a mutual interdependence between the prefrontal cortex and the hippocampus [Mogensen et al, 2004a[Mogensen et al, , 2005[Mogensen et al, , 2007. The performance pattern of the group with combined lesions (COMB/RS) in the present study gives further support to our previous conclusions.…”

“…However, studies examining the role of these two structures within a single behavioural paradigm are less frequent [Floresco et al, 1997;Kosaki and Watanabe, 2012;Lee and Solivan, 2008;Mogensen et al, 2004aMogensen et al, , 2005Mogensen et al, , 2007. Posttraumatic functional recovery studies from our laboratory indicate that the hippocampus contributes to the neural substrate for the functional recovery after prefrontal lesions and vice versa in a number of different tasks [Mogensen et al, 2004a[Mogensen et al, , 2005[Mogensen et al, , 2007. These and other studies [e.g.…”

“…There is a rapid information exchange between the PFC and hippocampus during the consolidation of information as the PFC gradually modulates the expression of memories that originally depended on the hippocampus [Takehara-Nishiuchi and McNaughton, 2008]. These two brain regions also contribute to the mediation of a number of the same tasks [Floresco et al, 1997;Lee and Solivan, 2008;Mogensen et al, 2007] and it is therefore highly relevant to scrutinize their cross-talk both during the task acquisition process and during the process of posttraumatic functional recovery. Numerous studies have investigated the contribution of either the PFC or the hippocampus to task acquisition [e.g.…”

Cognitive Recovery and Rehabilitation After Brain Injury: Mechanisms, Challenges and Support

“…An extensive animal model-based research program (e.g. Mogensen et al, 2002Mogensen et al, , 2003Mogensen et al, , 2004aMogensen et al, , 2005Mogensen et al, , 2007 has scrutinized the mechanisms of posttraumatic recovery processes. Utilizing a spectrum of organic and behavioural/cognitive "challenge" methods (e.g.…”

Memory‐related changes in L‐citrulline and agmatine in the rat brain

“…Lesions of the rat prefrontal cortex result in impaired performance in the DNMP task in the T-maze (Mogensen et al, 2007). Rossetti and Carboni (1998) reported T-maze training-induced noradrenaline and dopamine elevations in the rat prefrontal cortex.…”