Prefrontal delta oscillations during deep brain stimulation predict treatment success in patients with obsessive-compulsive disorder

Smith, Ezra E.; Schüller, Thomas; Huys, Daniel; Baldermann, Juan Carlos; Ullsperger, Markus; Allen, John J. B.; Visser‐Vandewalle, Veerle; Kuhn, Jens; Gruendler, Theo O.J.

doi:10.1016/j.brs.2019.09.008

Cited by 10 publications

(5 citation statements)

References 10 publications

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“…A later study performed a ROI-based analysis of directional functional connectivity, showing that active DBS increased the impact of the vmPFC on an amygdala-insula network along improvements in depression and anxiety symptoms (10). Moreover, there is a number of electrophysiological studies showing that active DBS of the ALIC/NAc interferes with low frequency oscillations within the mPFC/ACC which can be linked to improvements in obsessions and compulsions (7,8,37) and cognitive performance during conflicts (here, DBS increased theta power in mPFC and vlPFC in patients with OCD and depression) (38). The role of ACC mediated cognitive performance during conflict in neuromodulation for OCD is further supported by data from patients undergoing cingulotomy (39)(40)(41).…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“…Remarkably, different DBS targets have shown comparable response rates in OCD (5,6). Prior work demonstrating that DBS exerts clinical effects beyond the local/focal stimulation target (7,8) has motivated the concept of a broader, potentially shared neural network responsible for improvement of obsessions and compulsions. In parallel, OCD is a heterogeneous disorder with evidence suggesting that a varying set of multiple networks may be affected in each patient and thus relevant for neuromodulatory treatment (9).…”

Section: Introductionmentioning

confidence: 99%

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Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder

Baldermann

Schüller

Kohl

et al. 2021

Biological Psychiatry

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder

Baldermann

Schüller

Kohl

et al. 2021

Biological Psychiatry

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“…48,49 In contrast, DBS-induced increased delta frequency (1-4 Hz) restingstate activation in the MFC has been linked to clinical improvement for ALIC/NAc DBS. 14 We observed an interrelation between presurgery ERN and clinical efficacy, with large ERN amplitudes being associated with limited clinical success. No other patients' attributes (eg, age, sex, symptom severity) were predictive of clinical efficacy.…”

Section: Discussionmentioning

confidence: 73%

“…[9][10][11][12] The therapeutic effect is partly mediated by modulation of fronto-striatal networks involving NAc and MFC. [13][14][15] How these changes are related to specific performance monitoring processes is largely unknown. Electrophysiological research in OCD has focused on the error-related negativity (ERN).…”

Section: Introductionmentioning

confidence: 99%

Deep Brain Stimulation Reduces Conflict-Related Theta and Error-Related Negativity in Patients With Obsessive–Compulsive Disorder

Sildatke

Gruendler²,

Ullsperger

et al. 2022

Neuromodulation: Technology at the Neural Interface

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“…Moreover, alpha activity in both resting state and during desynchronization has recently been reported as potential biomarker postivelty correlated with motor recovery post-stroke [29,30]. Delta wave enhancement in prefrontal cortex has been shown to prdict fewer obsessive-compulsive disorder (OCD) symptoms after Deep brain stimulation (DBS) [31]. Gamma wave modulation demonstrated to mitigate the cognitive dysfunction in cerebral ischemia [32].…”

Section: Introductionmentioning

confidence: 99%

A Salutogenic Signature of the Placebo Effect in Brain Oscillations: A Systematic Review and Meta-Analysis

Fregni,

Ortega-Márquez,

Gonzalez-Gonzalez

et al. 2024

Preprint

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Brain oscillatory activity and its role as a biomarker in mental health and human behavioral mechanisms stands as an unexplored tool to explain the placebo effect. This systematic review and meta-analysis characterize, for the first time, the neural mechanistic biomarkers of placebo effect in neurorehabilitation. A systematic literature search based on PRISMA guidelines was conducted in PubMed, Embase, and Cochrane Library including randomized controlled trials (RCTs), and cross-over trials up to August 2023. The review included studies reporting brain oscillations in resting state as outcome in placebo-controlled neurorehabilitation trials. A qualitative, semi-quantitative, quantitative analysis was performed using minimal statistical information from each study and calculating effect sizes of absolute power differences between placebo and active intervention groups using Hedges’ g statistic method. The analysis included 63 studies: 5 (180 healthy subjects) and 58 (1758 patients with neurological disorders). In healthy population, placebo interventions showed an increase in alpha power when comparing versus no intervention (g = 0.45, 95% CI [0.09; 0.8]). In subjects with neurological disorders sham intervention showed increase in alpha frontal (g = 0.08, 95% CI [0.07; 0.08] ), alpha central (g = 0.55, 95% CI [0.47; 0.65]), alpha parietal (g = 0.28, 95% CI [0.18; 0.44]), beta central (g = 1.31, 95% CI [1.06; 1.63]), and theta central (g = 0.58, 95% CI [0.46; 0.72]). Interestingly, these effects became non-significant when comparing with the active interventions. In both populations, the enhancement of alpha oscillations in fronto-central regions emerged as the primary neural biomarker of the placebo effect. Furthermore, increase in beta and theta bands within the same brain regions were also noted as potential biomarkers, particularly in non-healthy subjects. Intriguingly, these effects were reversed when compared to active rehabilitation interventions, suggesting that active rehabilitation techniques also encompass the placebo effect. Our novel results show that placebo neural effects depend on the brain oscillatory baseline (healthy vs. patient populations), and they seem to unmask a more homeostatic salutogenic rhythm, such as alpha oscillations in healthy subjects and theta and beta oscillations in patient populations.

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Prefrontal delta oscillations during deep brain stimulation predict treatment success in patients with obsessive-compulsive disorder

Cited by 10 publications

References 10 publications

Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder

Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder

Deep Brain Stimulation Reduces Conflict-Related Theta and Error-Related Negativity in Patients With Obsessive–Compulsive Disorder

A Salutogenic Signature of the Placebo Effect in Brain Oscillations: A Systematic Review and Meta-Analysis

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