Prefrontal Dopamine D₁ and D₂ Receptors Regulate Dissociable Aspects of Decision Making via Distinct Ventral Striatal and Amygdalar Circuits

Dopamine Release in Antidepressant-Naive Major Depressive Disorder: A Multimodal [11C]-(+)-PHNO Positron Emission Tomography and Functional Magnetic Resonance Imaging Study

“…D 2 /D 3 receptor interacting partners within the ventral striatum, such as DA transporter, D 1 receptors, or components of the signaling pathways downstream of D 2 /D 3 receptors, could impact response to reward in MDD (91–93). The serotonergic system also modulates reward responses (94,95), and abnormalities of glutamate or dopamine in other brain regions, such as in the frontal cortex, could also influence BOLD response in the striatum (96–97). The role of frontostriatal pathways in anhedonic depression might be clarified by PET studies with radioligands allowing assessment of cortical D 2 /D 3 receptors (e.g.…”

Thalamic afferents to prefrontal cortices from ventral motor nuclei in decision‐making

“…With an elaborate design that involved local infusions of dopamine D1 or D2 antagonists into PrL, and inactivation of basolateral amygdala or nucleus accumbens, it was observed that rats under control conditions show: a‐ preference for a large/risky option if the probability of obtaining a larger reward increases or b‐ the preference for a larger reward gradually shifts the choice if the reward probabilities decrease. In experimental animals D1 or D2 dopaminergic modulation of PrL output neurons to nucleus accumbens, impairs risk/reward decision‐making, whereas only D2 receptors in cortical output neurons to basolateral amygdala, facilitate changes from an initial unfavorable selection, toward a more profitable choice (Jenni et al ., ).…”

“…Sessions begin with the chamber light turning on and presentation of both levers. One lever delivers one food pellet every time it is pressed (low risk or "small/certain" choice) and the other delivers four pellets with an attached probability of 1, 0.5, 0.25, or 0.125 (high risk or "larger/ risky" choice) (Floresco & Whelan, 2009;Jenni et al, 2017). For variations of this paradigm see for example Ghods-Sharifi et al (2009).…”

Vulnerable and resilient cognitive performance related to early life stress: The potential mediating role of dopaminergic receptors in the medial prefrontal cortex of adult mice

“…In addition, animal data (Fuke et al, 2006;Jenni et al, 2017;Puig & Miller, 2015;Vijayraghavan et al, 2007) have been found depletion on Hers1 gene expression associated with increased DAT and DA receptors gene expression. This upregulation response as consequence of Hers1 changes could influence the sensitivity of DA transmission, affecting the animal's behavior on cognitive tasks (Fuke et al, 2006;Knowles, Mathias, et al, 2014).…”

“…As the PFC is one of the brain regions that are most sensitive to the effects of ELS and pronounced cognitive deficits are observed in PFC‐dependent tasks (Arnsten, ; Grassi‐Oliveira et al, ; Viola et al, ), it is crucial to identify the potential mechanisms that can explain the adverse effects of stress on PFC functionality. One interesting hypothesis about PFC regulation is related to the role of dopamine signaling in specific networks and their output pathways, which affect distinct cognitive functions that are dependent on this brain region (e.g., working memory, attention, planning and solving problems, cognitive flexibility, decision making and goal‐directed behaviors) (Holroyd & Umemoto, ; Jenni, Larkin, & Floresco, ; Kehagia, Murray, & Robbins, ; Puig, Antzoulatos, & Miller, ; Puig & Miller, ; Winstanley & Floresco, ). During cognitive tasks that require PFC recruitment, a significant release of endogenous dopamine (DA) as a consequence of DA neuron stimulation has been identified (Murphy, Arnsten, Goldman‐Rakic, & Roth, ; Ott & Nieder, ; Vijayraghavan, Wang, Birnbaum, Williams, & Arnsten, ).…”