2016
DOI: 10.1371/journal.pbio.1002576
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Prefrontal Markers and Cognitive Performance Are Dissociated during Progressive Dopamine Lesion

Abstract: Dopamine is thought to directly influence the neurophysiological mechanisms of both performance monitoring and cognitive control—two processes that are critically linked in the production of adapted behaviour. Changing dopamine levels are also thought to induce cognitive changes in several neurological and psychiatric conditions. But the working model of this system as a whole remains untested. Specifically, although many researchers assume that changing dopamine levels modify neurophysiological mechanisms and… Show more

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Cited by 10 publications
(13 citation statements)
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References 88 publications
(178 reference statements)
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“…Finally, in a monkey model of Parkinson's disease, frontal beta power changes have been tracked and partially reflected reduced engagement in the trial and error task induced by a progressive dopaminergic system lesion (Wilson et al, 2016). In the present study, PD patients showed on average significantly worse scores on the apathy scale, but those scores did not correlate with the beta power measured during the first minutes of EEG recordings.…”
Section: Parkinson's Disease and Task-related Oscillationssupporting
(Expert classified)
See 1 more Smart Citation
“…Finally, in a monkey model of Parkinson's disease, frontal beta power changes have been tracked and partially reflected reduced engagement in the trial and error task induced by a progressive dopaminergic system lesion (Wilson et al, 2016). In the present study, PD patients showed on average significantly worse scores on the apathy scale, but those scores did not correlate with the beta power measured during the first minutes of EEG recordings.…”
Section: Parkinson's Disease and Task-related Oscillationssupporting
(Expert classified)
“…One assumption is that performance monitoring signals (FRN or ERN) correlate with the state of dopaminergic transmission (Jocham and Ullsperger, 2009). This has been tested pharmacologically in non-human primates for FRN (Vezoli and Procyk, 2009;Wilson et al, 2016) and in humans (Zirnheld et al, 2004). In a progressive and pre-symptomatic monkey model of Parkinson's disease, the FRN was the most altered marker of the lesion, although this effect was found in the absence of behavioral deficit in a deterministic trial and error learning task (Wilson et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Progress toward understanding ACC function has been impeded by its diverse response profile at the global and neuronal levels (Ebitz and Hayden, 2016). However, macroelectrophysiological signals in rats (Warren et al, 2015), monkeys (Wilson et al, 2016), and humans (Sambrook and Goslin, 2015) indicate that the ACC responds in a consistent manner when predictions about forthcoming outcomes are violated. In the present study, we discovered important aspects of ACC neuronal activity in such situations.…”
Section: Discussionmentioning
confidence: 99%
“…When learning which actions are associated with higher or lower levels of effort, PEs in ACC drive the learning, allowing individuals to minimize costs incurred when obtaining beneficial outcomes ( Scholl et al, 2015 , Skvortsova et al, 2014 ). Very recent evidence also suggests that outcome related signals putatively originating from ACC are impaired after dopaminergic lesions even when performance on a task requiring the monitoring of outcomes is unimpaired ( Wilson et al, 2016 ).…”
Section: Behavioural and Cognitive Neuroscience Of Motivation: Tradinmentioning
confidence: 99%