Prefrontal–posterior parietal networks in schizophrenia: primary dysfunctions and secondary compensations

Quintana, Javier; Wong, Thomas K. F.; Ortiz-Portillo, Elena; Kovalik, Edward; Davidson, Thomas A.; Marder, Stephen R.; Mazziotta, John C.

doi:10.1016/s0006-3223(02)01435-x

Cited by 121 publications

(70 citation statements)

References 112 publications

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“…This will occur even if the cues do not predict where the target will appear. Given that for overt attention, the gaze cue is directly congruent with the direction of a performed motor behaviour (i.e., the cue and participant look the same way), many authors suggest that this and similar results may be due to facilitation and interference from observed oculomotor preparation (Mansfield, Farroni, & Johnson, 2003;Quintana et al, 2003). This position, which can be called the 'gaze imitation hypothesis', posits that observed eye gaze causes the activation of an oculomotor program in the observer, and that this subsequently affects the performance of the same gaze behaviour.…”

Section: Overt Attentionmentioning

confidence: 96%

Visual attention and action: How cueing, direct mapping, and social interactions drive orienting

2017

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Despite considerable interest in both action perception and social attention over the last 2 decades, there has been surprisingly little investigation concerning how the manual actions of other humans orient visual attention. The present review draws together studies that have measured the orienting of attention, following observation of another's goal-directed action. Our review proposes that, in line with the literature on eye gaze, action is a particularly strong orienting cue for the visual system. However, we additionally suggest that action may orient visual attention using mechanisms, which gaze direction does not (i.e., neural direct mapping and corepresentation). Finally, we review the implications of these gaze-independent mechanisms for the study of attention to action. We suggest that our understanding of attention to action may benefit from being studied in the context of joint action paradigms, where the role of higher level action goals and social factors can be investigated.

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Section: Overt Attentionmentioning

confidence: 96%

Visual attention and action: How cueing, direct mapping, and social interactions drive orienting

2017

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“…Thus, individuals with schizophrenia may engage a larger network of cortical regions to compensate for reduced neural signalto-noise stemming in part from prefrontal cortical dysfunction. 74,76,77 This might explain why working memory performance was associated with cortical thickness in temporal regions in schizophrenia patients. Interestingly, a recent fMRI study confirmed that schizophrenia patients but not HCs activated the bilateral middle temporal gyrus significantly for increased accuracy during working memory.…”

Section: Working Memory and Cortical Thickness In Associated Brain Rementioning

confidence: 99%

Associations of Cortical Thickness and Cognition in Patients With Schizophrenia and Healthy Controls

Ehrlich

Brauns

Yendiki

et al. 2011

Schizophrenia Bulletin

159

100

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Previous studies have found varying relationships between cognitive functioning and brain volumes in patients with schizophrenia. However, cortical thickness may more closely reflect cytoarchitectural characteristics than gray matter density or volume estimates. Here, we aimed to compare associations between regional variation in cortical thickness and executive functions, memory, as well as verbal and spatial processing in patients with schizophrenia and healthy controls (HCs). We obtained magnetic resonance imaging and neuropsychological data for 131 patients and 138 matched controls. Automated cortical pattern matching methods allowed testing for associations with cortical thickness estimated as the shortest distance between the gray/white matter border and the pial surface at thousands of points across the entire cortical surface. Two independent measures of working memory showed robust associations with cortical thickness in lateral prefrontal cortex in HCs, whereas patients exhibited associations between working memory and cortical thickness in the right middle and superior temporal lobe. This study provides additional evidence for a disrupted structure-function relationship in schizophrenia. In line with the prefrontal inefficiency hypothesis, schizophrenia patients may engage a larger compensatory network of brain regions other than frontal cortex to recall and manipulate verbal material in working memory.

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“…pseudo-form) or outside their heads. Many neuroimaging and neurophysiological studies have made reference to hypo- [2,3] or hyperactivity [4] in the frontal and temporal areas, and their decreased connectivity per se [5,6,7,8] during auditory hallucinations or the internal/silent speech (often called sub-vocalization) of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

EEG Theta Power and Coherence to Octave Illusion in First-Episode Paranoid Schizophrenia with Auditory Hallucinations

Zheng

Chai²,

Yu³

et al. 2014

Psychopathology

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Background: The exact mechanism behind auditory hallucinations in schizophrenia remains unknown. A corollary discharge dysfunction hypothesis has been put forward, but it requires further confirmation. Electroencephalography (EEG) of the Deutsch octave illusion might offer more insight, by demonstrating an abnormal cerebral activation similar to that under auditory hallucinations in schizophrenic patients. Methods: We invited 23 first-episode schizophrenic patients with auditory hallucinations and 23 healthy participants to listen to silence and two sound sequences, which consisted of alternating 400- and 800-Hz tones. EEG spectral power and coherence values of different frequency bands, including theta rhythm (3.5-7.5 Hz), were computed using 32 scalp electrodes. Task-related spectral power changes and task-related coherence differences were also calculated. Clinical characteristics of patients were rated using the Positive and Negative Syndrome Scale. Results: After both sequences of octave illusion, the task-related theta power change values of frontal and temporal areas were significantly lower, and the task-related theta coherence difference values of intrahemispheric frontal-temporal areas were significantly higher in schizophrenic patients than in healthy participants. Moreover, the task-related power change values in both hemispheres were negatively correlated and the task-related coherence difference values in the right hemisphere were positively correlated with the hallucination score in schizophrenic patients. Limitations: We only tested the Deutsch octave illusion in primary schizophrenic patients with acute first episode. Further studies might adopt other illusions or employ other forms of schizophrenia. Conclusion: Our results showed a lower activation but higher connection within frontal and temporal areas in schizophrenic patients under octave illusion. This suggests an oversynchronized but weak frontal area to exert an action to the ipsilateral temporal area, which supports the corollary discharge dysfunction hypothesis.

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Prefrontal–posterior parietal networks in schizophrenia: primary dysfunctions and secondary compensations

Cited by 121 publications

References 112 publications

Visual attention and action: How cueing, direct mapping, and social interactions drive orienting

Visual attention and action: How cueing, direct mapping, and social interactions drive orienting

Associations of Cortical Thickness and Cognition in Patients With Schizophrenia and Healthy Controls

EEG Theta Power and Coherence to Octave Illusion in First-Episode Paranoid Schizophrenia with Auditory Hallucinations

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