Pregnancy, Abortion, and Ectopic Pregnancy

Mazur, Michael T.; Kurman, Robert J.

doi:10.1007/978-0-387-26321-2_3

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…These findings were consistent with a missed abortion or conceptus with degeneration. However, the findings in our case do not exclude the possibility of a live fetus coexisting with an early partial hydatidiform mole or even an invasive mole (10,(16)(17)(18), although we favor that the retained villi were normal. The curettage procedures would have resulted in placental and/or uterine mechanical disruption, creating a risk factor for embolization because of direct access of trophoplastic tissues to the uterine veins draining the maternal intervillous space.…”

Section: Discussioncontrasting

confidence: 65%

Placental Villotrophoblastic Pulmonary Emboli After Elective Abortion

Kamoi

Ohaki²,

Mori³

et al. 2003

International Journal of Gynecological Pathology

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Although pulmonary trophoblastic embolism is now considered a physiologic phenomenon of normal pregnancy, this phenomenon has not been demonstrated in a living asymptomatic patient. Recently we encountered a 26-year-old woman suspected of pulmonary embolism of villotrophoblastic tissues after therapeutic abortion. Although her serum beta-hCG was low, a computed tomography scan showed multiple nodules in both lungs. Histological examination of a nodule in a lung-biopsy specimen showed granulation tissue surrounding a hemorrhagic mass within which were structures resembling degenerating chorionic villi. Immunohistochemical study on the patient's lung nodule, and a second endometrial-curettage specimen, six control endometrial and tubal specimens containing degenerating chorionic villi, and four endometrial specimens containing viable chorionic villi were performed. The patterns of immunostaining for cytokeratin, human chorionic gonadotropin, human placental lactogen, placental alkaline phosphatase, and inhibin-alpha of the chorionic villus-like structures in the lung nodule were almost identical to those in the degenerating chorionic villi, but different from those of viable villi. This is a unique case of embolism of chorionic villi and trophoblast to the lung in a living patient after therapeutic abortion.

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Section: Discussioncontrasting

confidence: 65%

Placental Villotrophoblastic Pulmonary Emboli After Elective Abortion

Kamoi

Ohaki²,

Mori³

et al. 2003

International Journal of Gynecological Pathology

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Negative for Malignant Tumors and Precursors: TYS1

Norimatsu

Nishikawa

Kobayashi

et al. 2022

The Yokohama System for Reporting Endometrial Cytology

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Mixed Germ Cell Tumor with Embryonal Carcinoma, Choriocarcinoma, and Epithelioid Trophoblastic Tumor in the Ovary of a Cynomolgus Monkey

et al. 2011

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A seven-year-old female cynomolgus monkey had a mass in the left ovary with metastasis to the lung and the right ovary. The mass of these organs showed three different characteristics, and its immunohistochemical profiles were consistent with embryonal carcinoma (EC), choriocarcinoma (CC), and epithelioid trophoblastic tumor (ETT). The EC was characterized with sheets and glandlike structures with large pleomorphic, single-nucleated epithelial cells that were immunohistochemically positive for α-fetoprotein, octamer-4, and CD30, and with multinucleated giant cells resembling syncytiotrophoblasts. The CC also represented biphasic proliferation of the cytotrophoblast positive for cytokeratin 7 (CK7), which showed negative immunoreactivity for all three of the above antibodies, and it was syncytiotrophoblast positive for human chorionic gonadotropin. The ETT showed numerous floating cells in an abundant eosinophilic extracellular matrix with vacuolated or eosinophilic cytoplasm and was immunohistochemically positive for CK7, p63, and α-inhibin, which features nodule or cordlike structures. Collectively, this neoplasm was identified as a mixed germ cell tumor with EC, CC, and ETT. To our knowledge, this is the first report of EC in nonhuman primates as a component of mixed germ cell tumor.

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Pregnancy, Abortion, and Ectopic Pregnancy

Cited by 3 publications

References 46 publications

Placental Villotrophoblastic Pulmonary Emboli After Elective Abortion

Placental Villotrophoblastic Pulmonary Emboli After Elective Abortion

Negative for Malignant Tumors and Precursors: TYS1

Mixed Germ Cell Tumor with Embryonal Carcinoma, Choriocarcinoma, and Epithelioid Trophoblastic Tumor in the Ovary of a Cynomolgus Monkey

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