Pregnancy after Transplantation of Cryopreserved Ovarian Tissue in a Patient with Ovarian Failure after Chemotherapy

Meirow, Dror; Levron, Jacob; Eldar‐Geva, Talia; Hardan, Izhar; Fridman, Eduard; Zalel, Yaron; Schiff, Eyal; Dor, Jehoshua

doi:10.1056/nejmc055237

Cited by 801 publications

(519 citation statements)

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“…Furthermore, the removal and appropriate cryopreservation of a small area of ovary containing an abundance of primordial follicles has more theoretical potential for future fertility than cryopreserved oocytes (Gook et al, 1999(Gook et al, , 2003. This tissue can then be reimplanted either orthotopically (Radford et al,2001;Meirow et al, 2005), or heterotopically (Donnez et al, 2004;Oktay et al, 2004;Wolner-Hanssen et al, 2005), with the demonstrated capacity to restore both endocrine function and fertility (Donnez et al, 2004;Meirow et al, 2005).…”

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confidence: 99%

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Lack of evidence of disease contamination in ovarian tissue harvested for cryopreservation from patients with Hodgkin lymphoma and analysis of factors predictive of oocyte yield

et al. 2006

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Ovarian cryopreservation is a promising technique to preserve fertility in women with Hodgkin lymphoma (HL) treated with chemotherapy. Thus, the aim of this study was to examine harvested ovarian tissue for subclinical involvement by HL by morphology/ immunohistochemistry, and to define patient and treatment factors predictive of oocyte yield. This was a retrospective analysis of 26 ovarian tissue samples harvested for cryopreservation from women with HL. Histology, immunohistochemistry and follicle density (number mm À3 ) was examined. Disease status and preharvest chemotherapy details were obtained on 24 patients. The median age was 22 years (range 13 -29). Seven of 24 patients had infradiaphragmatic disease at time of harvest. Nine of 20 patients had received chemotherapy preharvest (ABVD (Adriamycin s , Bleomycin, Vinblastine and Dacarbazine) ¼ 7, other regimens ¼ 2). The seven receiving ABVD showed no difference in follicle density compared to patients not receiving treatment (n ¼ 14); (median ¼ 1555 vs 1620 mm 3 P ¼ 0.97). Follicle density measurement showed no correlation with patient age (R 2 ¼ 0.0001, P ¼ 0.99). There was no evidence of HL involvement in the 26 samples examined (95% CI ¼ 0 -11%). In conclusion, subclinical involvement of HL has not been identified in ovarian tissue, even when patients have infradiaphragmatic disease. Furthermore, the quality of tissue harvested does not appear to be adversely affected by patient's age or prior ABVD chemotherapy.

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“…In addition, there have been two reports of a successful pregnancy and live birth, which resulted from the reimplantation of frozen ovarian tissue into patients with HL and non-Hodgkin's lymphoma (NHL) (Donnez et al, 2004;Meirow et al, 2005).…”

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Lack of evidence of disease contamination in ovarian tissue harvested for cryopreservation from patients with Hodgkin lymphoma and analysis of factors predictive of oocyte yield

et al. 2006

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“…Ovarian cryopreservation aims to preserve primordial follicles, which are presumably less damaged by chemotherapy than growing follicles [4]. Meirow et al reported a live birth after autotransplantation of ovarian tissue that had been cryopreserved after a first line of chemotherapy [37]. But we have to keep in mind that chemotherapy regimens damage the ovaries through apoptotic effects but also through cortical fibrosis and blood microvessels injury [38].…”

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Detection of Non-Hodgkin’s Lymphoma in ovarian cortex pieces during the process of cryopreservation

Gronier

Terriou

Robin

et al. 2014

J Assist Reprod Genet

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“…O restabelecimento de função ovariana pós-reimplante de tecido ovariano congelado-descongelado já foi descrito por alguns autores [23][24][25] , inclusive com nascimento de criança sadia após falência ovariana pós-quimioterapia comprovada, seja por gestação espontânea 26,27 ou por técnicas de reprodução assistida 28 . A conservação do tecido em si a partir de técnicas de congelamento não é tão complicada.…”

Section: Criopreservação De Oócitosunclassified

Preservação de fertilidade

Silva

Sá²

2006

Rev. Bras. Ginecol. Obstet.

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RESUMOCom a evolução dos recursos terapêuticos e o aumento das taxas de sobrevida dos pacientes oncológicos, as repercussões tardias destas terapias, que antes eram infreqüentes, hoje assumem um papel importante quando se fala em qualidade de vida. Dentre estas complicações tardias está a perda da função ovariana. Segundo as recomendações da Sociedade Americana de Oncologia Clínica (American Society of Clinical Oncology) recentemente publicadas, os métodos comprovadamente efi cazes para preservação da fertilidade feminina disponíveis hoje são: o congelamento de embriões, a cirurgia ginecológica conservadora e a ooforopexia para os casos de radioterapia localizada. Todas as demais técnicas existentes, tais como a supressão ovariana medicamentosa e a criopreservação de tecido ovariano e de oócitos, embora apresentem resultados promissores, ainda são consideradas experimentais. A escolha da melhor técnica para preservação de fertilidade aplicável em cada caso vai depender da idade da paciente, do tipo de tratamento, da existência ou não de parceiro com quem deseje constituir prole, do tempo disponível até o início da quimioterapia e do potencial do câncer em produzir metástase ovariana. Neste artigo as técnicas disponíveis e experimentais para a preservação da fertilidade são revisadas e discutidas. PALAVRAS-CHAVE:Falência ovariana prematura; Criopreservação; Quimioterapia; Radioterapia; Infertilidade ABSTRACTAs therapeutic approaches for oncologic diseases are being improved and an increase in the survival rates are being achieved, long-term complications of these therapies, initially infrequent, assume these days an important place when considering life quality. Among the long term repercussions appears the premature ovarian failure. According to the recommendations of the American Society of Clinical Oncology recently published, the only procedures available nowadays considered to be effective for female fertility preservation are: embryo cryopreservation, conservative gynecological surgery and oophoropexy in cases of local radiotherapy. All the other proposed techniques, surch as: ovarian suppression and oocyte and ovarian tissue cryopreservation, although present promising results, are still considered as experimental options. The best choice for fertility preservation in each specifi c case depends on patient's age, type of treatment, existence of a partner, time available until chemo-or radiotherapy beginning, and the ovarian metastatic potential of the tumor. In the present manuscript, the available and experimental techniques for fertility preservation are revised and discussed. KEYWORDS:

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Pregnancy after Transplantation of Cryopreserved Ovarian Tissue in a Patient with Ovarian Failure after Chemotherapy

Cited by 801 publications

References 8 publications

Lack of evidence of disease contamination in ovarian tissue harvested for cryopreservation from patients with Hodgkin lymphoma and analysis of factors predictive of oocyte yield

Lack of evidence of disease contamination in ovarian tissue harvested for cryopreservation from patients with Hodgkin lymphoma and analysis of factors predictive of oocyte yield

Detection of Non-Hodgkin’s Lymphoma in ovarian cortex pieces during the process of cryopreservation

Preservação de fertilidade

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