Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet

Shrestha, Nirajan; Sleep, Simone L.; Cuffe, James; Holland, Olivia J.; McAinch, Andrew J.; Nitert, Marloes Dekker; Hryciw, Deanne H.

doi:10.1152/ajpendo.00265.2019

Cited by 13 publications

(12 citation statements)

References 45 publications

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“…Alpha-linolenic acid (ALA) has a significant regulatory effect on the gut microbiota of mice fed a high-fat diet [ 28 ]. In addition, dietary linoleic acid (LA) altered fecal microbiome diversity before and during pregnancy [ 29 ]. It has been hypothesized that these fatty acids could exert their reductive effects on Cd accumulation by sustaining some key members of the gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

Oleic Acid Facilitates Cd Excretion by Increasing the Abundance of Burkholderia in Cd-Exposed Mice

Fang

Chen

et al. 2022

IJMS

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As a global pollutant, cadmium (Cd) can easily enter the body through food chains, threatening human health. Most Cd is initially absorbed in the gut, with the gut microbiota playing a pivotal role in reducing Cd absorption and accumulation. This study assessed the effects of three fatty acids on Cd accumulation and toxicity in Cd-exposed mice. The results showed that oleic acid (OA) was the most effective in facilitating Cd excretion in mice among these fatty acids. The use of OA led to reduced Cd accumulation in the organs and increased Cd content in the feces. The metagenomic analysis of the gut microbiota showed that the genus Burkholderia was the most significantly restored by OA in Cd-exposed mice. Burkholderia cepacia, as the type species for the genus Burkholderia, also exhibited strong Cd tolerance after treatment with OA. Furthermore, the electron microscopy analysis showed that most of the Cd was adsorbed on the surface of B. cepacia, where the extracellular polymeric substances (EPSs) secreted by B. cepacia play a key role, displaying a strong capacity for Cd adsorption. The peak at 2355 cm−1 and the total sulfhydryl group content of EPSs showed significant increases following co-treatment with Cd and OA. The results demonstrated the potential roles that gut Burkholderia may play in OA-mediated Cd excretion in mice.

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Section: Introductionmentioning

confidence: 99%

Oleic Acid Facilitates Cd Excretion by Increasing the Abundance of Burkholderia in Cd-Exposed Mice

Fang

Chen

et al. 2022

IJMS

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“…This is even more true when examining the effect of maternal dietary n -6 PUFA in a moderate fat diet during gestation and lactation on host–microbiota interactions. In a recent study, Shrestha et al demonstrated that a high consumption of LA (6.2% of energy) in a normal fat diet (9% of energy) does not significantly alter the gut microbiota composition of dams during pregnancy as compared to a lower intake of LA, but they did not investigate the offspring microbiota [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal Linoleic Acid Overconsumption Alters Offspring Gut and Adipose Tissue Homeostasis in Young but Not Older Adult Rats

et al. 2020

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Maternal n-6 polyunsaturated fatty acids (PUFA) consumption during gestation and lactation can predispose offspring to the development of metabolic diseases such as obesity later in life. However, the mechanisms underlying the potential programming effect of n-6 PUFA upon offspring physiology are not yet all established. Herein, we investigated the effects of maternal and weaning linoleic acid (LA)-rich diet interactions on gut intestinal and adipose tissue physiology in young (3-month-old) and older (6-month-old) adult offspring. Pregnant rats were fed a control diet (2% LA) or an LA-rich diet (12% LA) during gestation and lactation. At weaning, offspring were either maintained on the maternal diet or fed the other diet for 3 or 6 months. At 3 months of age, the maternal LA-diet favored low-grade inflammation and greater adiposity, while at 6 months of age, offspring intestinal barrier function, adipose tissue physiology and hepatic conjugated linoleic acids were strongly influenced by the weaning diet. The maternal LA-diet impacted offspring cecal microbiota diversity and composition at 3 months of age, but had only few remnant effects upon cecal microbiota composition at 6 months of age. Our study suggests that perinatal exposure to high LA levels induces a differential metabolic response to weaning diet exposure in adult life. This programming effect of a maternal LA-diet may be related to the alteration of offspring gut microbiota.

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“…Additionally, we identified that plasma levels of omega-3 and omega-6 oxylipins are negatively associated with the relative abundance of the Sutterella genus in feces. In line with these results, rats consuming a diet rich in the omega-6 PUFA LA for 10 weeks showed a decrease in the relative abundance of the Sutterella genus [ 35 ]. In contrast, daily oral supplementation with omega-3 PUFAs (i.e., 4 g of EPA and DHA) for eight weeks increased the relative abundance of Sutterellaceae family in feces of in middle-aged healthy humans [ 36 ].…”

Section: Discussionmentioning

confidence: 68%

Plasma Levels of Omega-3 and Omega-6 Derived Oxylipins Are Associated with Fecal Microbiota Composition in Young Adults

Jurado‐Fasoli

Ortiz-Alvarez

et al. 2022

Nutrients

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Pre-clinical studies suggest that circulating oxylipins, i.e., the oxidation products of polyunsaturated fatty acids (PUFAs), modulate gut microbiota composition in mice, but there is no information available in humans. Therefore, this study aimed to investigate the relationship between omega-3 and omega-6 derived oxylipins plasma levels and fecal microbiota composition in a cohort of young adults. 80 young adults (74% women; 21.9 ± 2.2 years old) were included in this cross-sectional study. Plasma levels of oxylipins were measured using liquid chromatography-tandem mass spectrometry. Fecal microbiota composition was analyzed by V3-V4 16S rRNA gene sequencing. We observed that plasma levels of omega-3 derived oxylipins were positively associated with the relative abundance of Clostridium cluster IV genus (Firmicutes phylum; rho ≥ 0.415, p ≤ 0.009) and negatively associated with the relative abundance of Sutterella genus (Proteobacteria phylum; rho ≥ −0.270, p ≤ 0.041), respectively. Moreover, plasma levels of omega-6 derived oxylipins were negatively associated with the relative abundance of Acidaminococcus and Phascolarctobacterium genera (Firmicutes phylum; all rho ≥ −0.263, p ≤ 0.024), as well as Sutterella, Succinivibrio, and Gemmiger genera (Proteobacteria phylum; all rho ≥ −0.263, p ≤ 0.024). Lastly, the ratio between omega-6 and omega-3 oxylipins plasma levels was negatively associated with the relative abundance of Clostridium cluster IV genus (Firmicutes phylum; rho = −0.334, p = 0.004) and Butyricimonas genus (Bacteroidetes phylum; rho = −0.292, p = 0.014). In conclusion, our results show that the plasma levels of omega-3 and omega-6 derived oxylipins are associated with the relative abundance of specific fecal bacteria genera.

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Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet

Cited by 13 publications

References 45 publications

Oleic Acid Facilitates Cd Excretion by Increasing the Abundance of Burkholderia in Cd-Exposed Mice

Oleic Acid Facilitates Cd Excretion by Increasing the Abundance of Burkholderia in Cd-Exposed Mice

Maternal Linoleic Acid Overconsumption Alters Offspring Gut and Adipose Tissue Homeostasis in Young but Not Older Adult Rats

Plasma Levels of Omega-3 and Omega-6 Derived Oxylipins Are Associated with Fecal Microbiota Composition in Young Adults

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