Pregnancy and maternal iron deficiency stimulate hepatic CRBPII expression in rats

Cottin, S; Gambling, Lorraine; Hayes, Helen; Stevens, Valerie Joan; McArdle, Harry J

doi:10.1016/j.jnutbio.2016.02.005

Cited by 21 publications

(16 citation statements)

References 36 publications

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“…Iron deficiency is highly prevalent in all age groups (Pasricha & Drakesmith, ). Some studies reported that 46% of children aged 5–14 years old and 48% of pregnant women in the world are anaemic (Cottin et al ., ). The majority of IDA cases were due to iron deficiency in the diet, poor iron absorption and excessive loss of iron (Denic & Agarwal, ).…”

Section: Introductionmentioning

confidence: 97%

“…Fortifiers of iron are often used to control IDA, such as oral supplements of ferrous salts (e.g. ferrous sulphate, ferrous succinate and ferrous gluconate) (Lebedev et al ., ). However, ferrous salts are chemically unstable due to the presence of free iron ions, which easily produce free radicals, leading to lipid peroxidation and gastrointestinal side effects (Mimura et al ., ; Cancelo‐Hidalgo et al ., ; Hernández et al ., ).…”

Section: Introductionmentioning

confidence: 97%

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Preparation and characterisation of a novel agar oligosaccharide–iron (III) complex

Teng

et al. 2018

Int J of Food Sci Tech

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This study aimed to synthesise a complex of agar oligosaccharides (AOS) with ferric iron and to evaluate its physicochemical and structural characteristics. Based on single factor, Plackett-Burman and response surface optimal experiments of three factors at three levels, the optimised chelate conditions of the AOSiron (III) complex were mass ratio of AOS to iron ions of 4.5:1 g:g, reaction temperature of 74°C and reaction time of 60 min. Under these conditions, the iron content and total sugar content were 14.03 AE 0.42% and 66.07 AE 0.96%, respectively. The physicochemical analysis showed that AOS-iron (III) was soluble and steady at physiological pH, and it was easily reduced to iron (II). The structural characteristics of AOS and AOS-iron (III) were analysed by Raman spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction and Nuclear magnetic resonance, and results showed that the iron (III) ions were chelated to AOS by -OH groups and -COOH groups and widely dispersed on the AOS backbone. Therefore, AOS-iron (III) could be a candidate for iron supplementation to treat iron deficiency anaemia.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Preparation and characterisation of a novel agar oligosaccharide–iron (III) complex

Teng

et al. 2018

Int J of Food Sci Tech

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“…The effect of maternal Fe deficiency on growth, placental:fetal ratio, placenta and liver weights, haematocrit and Fe levels in this study has been recently reported (28) . Specifically, Fe levels were decreased by 152•6 µg/g (approximately -30 %), 604•0 µg/g (approximately -60 %) and 369•4 µg/g dry tissue (approximately -75 %), in the placenta, fetal and maternal liver, respectively (28) .…”

Section: Copper and Zinc Levelsmentioning

confidence: 55%

The effect of maternal iron deficiency on zinc and copper levels and on genes of zinc and copper metabolism during pregnancy in the rat

Cottin¹,

Roussel²,

Gambling³

et al. 2018

Br J Nutr

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Fe deficiency is relatively common in pregnancy and has both short- and long-term consequences. However, little is known about the effect on the metabolism of other micronutrients. A total of fifty-four female rats were fed control (50 mg Fe/kg) or Fe-deficient diets (7·5 mg/kg) before and during pregnancy. Maternal liver, placenta and fetal liver were collected at day 21 of pregnancy for Cu and Zn analysis and to measure expression of the major genes of Cu and Zn metabolism. Cu levels increased in the maternal liver (P=0·002) and placenta (P=0·018) of Fe-deficient rats. Zn increased (P<0·0001) and Cu decreased (P=0·006) in the fetal liver. Hepatic expression of the Cu chaperones antioxidant 1 Cu chaperone (P=0·042) and cytochrome c oxidase Cu chaperone (COX17, P=0·020) decreased in the Fe-deficient dams, while the expression of the genes of Zn metabolism was unaltered. In the placenta, Fe deficiency reduced the expression of the chaperone for superoxide dismutase 1, Cu chaperone for superoxide dismutase (P=0·030), ceruloplasmin (P=0·042) and Zn transport genes, ZRT/IRT-like protein 4 (ZIP4, P=0·047) and Zn transporter 1 (ZnT1, P=0·012). In fetal liver, Fe deficiency increased COX17 (P=0·020), ZRT/IRT-like protein 14 (P=0·036) and ZnT1 (P=0·0003) and decreased ZIP4 (P=0·004). The results demonstrate that Fe deficiency during pregnancy has opposite effects on Cu and Zn levels in the fetal liver. This may, in turn, alter metabolism of these nutrients, with consequences for development in the fetus and the neonate.

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“…At present, the methods and techniques of drug target prediction can be divided into four parts according to their principles: (1) ligand prediction based on chemical structure similarity and pharmacophore models; (2) machine intelligence learning and prediction, for which standardized names and clear molecular target correspondence are required; (3) molecular docking, in which receptors are used to make predictions; and (4) combined prediction [32]. Building on the current conditions and constraints, we selected ligand prediction as the main method and supplemented it with data from DrugBank.…”

Section: Target Prediction For the Bioactive Ingredients Of Pramentioning

confidence: 99%

“…Worldwide, 46% of children aged 5 to 14 years and 48% of pregnant women suffer from iron-deficiency anaemia (IDA) [1,2]. IDA is one of the most widespread nutritional deficiency diseases [3] and can cause cognitive deficiency and irreversible auditory and visual system damage in infants [4,5].…”

Section: Introductionmentioning

confidence: 99%

Uncovering the mechanism of the effects of Paeoniae Radix Alba on iron-deficiency anaemia through a network pharmacology-based strategy

Deng

Ren

et al. 2020

BMC Complement Med Ther

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Background: Paeoniae Radix Alba, the root of the plant Paeonia lactiflora Pall, is a common blood-enriching drug in traditional Chinese medicine. Its effectiveness in the clinical treatment of anaemia is remarkable, but its potential pharmacologic mechanism has not been clarified. Methods: In this study, the potential pharmacologic mechanism of Paeoniae Radix Alba in the treatment of iron-deficiency anaemia was preliminarily elucidated through systematic and comprehensive network pharmacology. Results: Specifically, we obtained 15 candidate active ingredients from among 146 chemical components in Paeoniae Radix Alba. The ingredients were predicted to target 77 genes associated with iron-deficiency anaemia. In-depth analyses of these targets revealed that they were mostly associated with energy metabolism, cell proliferation, and stress responses, suggesting that Paeoniae Radix Alba helps alleviate irondeficiency anaemia by affecting these processes. In addition, we conducted a core target analysis and a cluster analysis of protein-protein interaction (PPI) networks. The results showed that four pathways, the p53 signalling pathway, the IL-17 signalling pathway, the TNF signalling pathway and the AGE-RAGE signalling pathway in diabetic complications, may be major pathways associated with the ameliorative effects of Paeoniae Radix Alba on iron-deficiency anaemia. Moreover, molecular docking verified the credibility of the network for molecular target prediction. Conclusions: Overall, this study predicted the functional ingredients in Paeoniae Radix Alba and their targets and uncovered the mechanism of action of this drug, providing new insights for advanced research on Paeoniae Radix Alba and other traditional Chinese medicines.

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Pregnancy and maternal iron deficiency stimulate hepatic CRBPII expression in rats

Cited by 21 publications

References 36 publications

Preparation and characterisation of a novel agar oligosaccharide–iron (III) complex

Preparation and characterisation of a novel agar oligosaccharide–iron (III) complex

The effect of maternal iron deficiency on zinc and copper levels and on genes of zinc and copper metabolism during pregnancy in the rat

Uncovering the mechanism of the effects of Paeoniae Radix Alba on iron-deficiency anaemia through a network pharmacology-based strategy

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