Pregnancy and melanoma

Case Report of a Pregnancy During Ipilimumab Therapy

“…No known mechanism by which pregnancy directly influences melanoma growth exists, and the prognosis in the case of melanoma does not appear to be affected by pregnancy. 6 The current patient’s melanoma progressed while receiving treatment during pregnancy; however, what role her pregnancy played in this progression is unknown.…”

Melanoma Following In Vitro Fertilization: Co-incident or Coincidence?

“…Indeed, melanoma is the most common malignancy in women during pregnancy. In addition, the pregnant women in whom melanoma is diagnosed have an increased risk for not only recurrence, but also metastases and death [3][4][5].…”

“…Specifically, melanoma growth and progression can be enhanced by decreased expression of estrogen receptor beta which normally seems to function as a tumor suppressor. However, the definitive mechanism of estrogen-associated melanoma carcinogenesis remains to be established; it might be postulated, in women following in vitro fertilization that the excess estrogen causes down regulation of estrogen receptor beta and thereby results in limiting the receptor-related suppression of melanoma [3][4][5][6][7].…”

“…The primary cause of melanoma is ultraviolet radiation from sun exposure or indoor tanning bed use [1][2][3]. Melanoma has been observed following delivery by natural pregnancy and in vitro fertilization-associated pregnancy [4][5][6]. A 43-year-old woman who had received in vitro fertilization and developed a melanoma five months after delivery of twins is described and the occurrence of post-in vitro fertilization melanoma is reviewed.…”

Pregnancy and Melanoma: Recommendations for Clinical Scenarios

“…Pregnancy is not contraindicated in women diagnosed with localized malignant melanoma (MM) ( Driscoll et al, 2016 ). There exists no conclusive evidence that pregnancy increases the risk of MM recurrence.…”