Pregnancy and perinatal outcomes in women with polycystic ovarian syndrome

Rizwana, A.; Rajkumar, Shery Angel; Anuradha, C R

doi:10.18203/2320-1770.ijrcog20214337

Cited by 3 publications

(4 citation statements)

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“…Această constatare este în concordanță cu datele din literatura de specialitate, care demonstrează că pacientele cu SOP prezintă un risc crescut pentru complicații perinatale așa ca: tulburări hipertensive induse de sarcină, diabet zaharat gestațional, prematuritate și avort spontan [4,8].. La această etapă este semnificativ de menționat că lotul I s-a micșorat la 53 paciente în urma acelor 7 avorturi spontane (tab. 2).…”

Section: Rezultate Și Discuțiiunclassified

“…Gravidele cu sindromul ovarelor polichiste prezintă un risc ridicat pentru complicații materne, care ulterior pot influența rezultatele perinatale [1,2,5,8].…”

Section: Introducereunclassified

“…Prin studierea anamnezei ginecologice și obstetricale a pacientelor cu sindromul ovarelor polichistice a fost posibil de identificat factorii predictivi de risc. La fel, a fost apreciată influența sindromului ovarelor polichistice asupra evoluției sarcinii și a nașterii [3,4,5,7,8].…”

Section: Introducereunclassified

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The particulars of the evolution of pregnancy and birth in pregnant women with polycystic ovary syndrome

Victoria

2024

BulMed

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Purpose. Identifying the particularities of pregnancy and birth in pregnant women with (PCOS) polycystic ovary syndrome. Material and methods. The study was retrospective which took place during the years 2020-2022 within IMSP SCM no. 1, patients divided into 2 groups: Group I – 60 patients with polycystic ovary syndrome and pregnancy achieved. Group II – 60 patients with normal pregnancy. According to its nature, the study carried out is descriptive observational. The method of accumulating and extracting data from the medical documentation did not allow the determination of anamnesticclinical peculiarities, clinical and paraclinical investigations (laboratory and instrumental), the evolution of the pregnancy and the birth of the pregnant women included in study, including the assessment of the status of the newborn at birth. Results. From the results of the conducted study we can confirm the following particularities of the pregnancy evolution in pregnant women with PCOS, that in the II group predominantly a single pregnancy was obtained in 57 (95±0.28%) cases and a twin pregnancy in 3 (5±0.28%). The same results were obtained in group I, 42 (70±0.59%) cases of single pregnancy and 16 (26.7±0.57%) cases of twin pregnancy. Through these research results, a significant statistical difference was found in these 2 groups (p<0.05), these obtained results of the study coincide with the data from the literature, which we can confirm that the obtained data of our study are true. Conclusion. The results of the comparative study show that the pregnancy of pregnant women with PCOS is completed mainly at term - 58.5% and mainly by caesarean section - 62.26%

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Section: Rezultate Și Discuțiiunclassified

“…Gravidele cu sindromul ovarelor polichiste prezintă un risc ridicat pentru complicații materne, care ulterior pot influența rezultatele perinatale [1,2,5,8].…”

Section: Introducereunclassified

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The particulars of the evolution of pregnancy and birth in pregnant women with polycystic ovary syndrome

Victoria

2024

BulMed

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“…There are two types of PE: early onset (symptoms appearing before 33 weeks) and late-onset (symptoms appear after 34 weeks) [1][2]. Although early and late-onset PE is related to some risk factors and overlaps in presenting symptoms, their effects on both mother and child can differ [3]. Placental perfusion problems cause proteinuria, edema, and multiple organ failure.…”

Section: Introductionmentioning

confidence: 99%

The role of biomarkers in early prediction and molecular mechanisms of preeclampsia

Kalarani¹,

Veerabathiran²,

Mohammed³

2022

Eur J Trans Clin Med

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Preeclampsia (PE) is defined as new onset hypertension after 20 weeks of gestation with evidence of maternal organ or uteroplacental dysfunction or proteinuria. PE is a leading cause of maternal death, with about 55000 deaths worldwide each year. Toxic substances that damage the maternal vascular endothelium induce PE, resulting in liver and kidney malfunction. It is crucial for obstetricians to identify as early as possible the patients who are at risk for PE. Polycystic ovarian disease, sleeping disorders, urinary infections, periodontal disease, smoking, lifestyle and familial history of PE are the major risk factors involved in this disease. VEGF, sFlt1, sENG, PAPP-A, inhibin A and activin A proteins, fetal hemoglobin, heat shock protein and placental protein have been helpful in predicting or diagnosing PE and in understanding its pathogenesis. In addition, a better understanding of PE pathogenesis would aid in identifying the most effective treatments that do not impair the fetus' prognosis. The aim of our study is a review of the pathophysiology and biomarkers, such as pro-and anti-angiogenic substances, that may be useful in the detection of PE in the future.

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Evaluating the impact of LHCGR gene polymorphism on polycystic ovary syndrome: a comprehensive meta-analysis and power assessment

Thomas,

Veerabathiran

2024

J Turkish German Gynecol Assoc

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Objective Polycystic ovary syndrome (PCOS) is prevalent among reproductive-aged women and is categorized by hormonal imbalances, irregular menstrual cycles, and challenges with fertility.PCOS affects approximately 3.6% of women globally, with prevalence varying by region. The luteinizing hormone/choriogonadotropin receptor (LHCGR) gene, which encodes the LHCGR , has been implicated in PCOS pathophysiology. This study investigated the association between the LHCGR gene polymorphism rs2293275 and PCOS through a meta-analysis. Material and Methods An extensive literature review was carried out using Embase, PubMed, and Google Scholar databases to identify research studies exploring the association between LHCGR gene variants and PCOS. The review was conducted based on the PRISMA checklist. Eligible case-control studies from 2016 to 2024 were chosen based on predefined criteria. Quantitative data analysis was performed using MetaGenyo software, employing a significance threshold of p<0.05. Odds ratios (OR) and confidence intervals (CI) were calculated to evaluate the relationships. G*Power 3.1 software was employed for statistical power analysis to assess the study’s strength. The meta-analysis explored the link between LHCGR gene variant rs2293275 and PCOS across diverse ethnic groups and genetic models. Results Analyzing data from 10 studies involving 1,431 PCOS cases and 1,317 controls, the findings revealed no significant associations in most genetic models: allele (OR: 0.89, 95% CI: 0.54-1.49), dominant (OR: 0.74, 95% CI: 0.47-1.18), recessive (OR: 0.80, 95% CI: 0.41-1.57), and over-dominant (OR: 1.13, 95% CI: 0.69-1.85). Subgroup analyses by ethnicity (Arabs, Asians, Caucasians) consistently showed no significant correlations, except a protective effect in Caucasians (OR: 0.57, 95% CI: 0.34-0.95) in the AA vs. aa comparison. Sensitivity analyses confirmed robustness, and there was no indication of publication bias. Power analysis validated adequate sample sizes, and protein-protein interaction networks underscored biological relevance. Conclusion The meta-analysis concluded that no significant connection was observed between the LHCGR gene variant rs2293275 and the risk of PCOS among different populations. This suggests a complexity in PCOS etiology and indicating that LHCGR may not be a significant genetic marker for PCOS. Future research should explore other genetic and environmental factors contributing to PCOS, emphasizing the importance of genetic and ethnic variability in such studies.

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Pregnancy and perinatal outcomes in women with polycystic ovarian syndrome

Cited by 3 publications

References 13 publications

The particulars of the evolution of pregnancy and birth in pregnant women with polycystic ovary syndrome

The particulars of the evolution of pregnancy and birth in pregnant women with polycystic ovary syndrome

The role of biomarkers in early prediction and molecular mechanisms of preeclampsia

Evaluating the impact of LHCGR gene polymorphism on polycystic ovary syndrome: a comprehensive meta-analysis and power assessment

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