Pregnancy-associated breast cancer: the risky status quo and new concepts of predictive medicine

Polívka, Jiří; Altun, Irem; Golubnitschaja, Olga

doi:10.1007/s13167-018-0129-7

Cited by 45 publications

(47 citation statements)

References 120 publications

(180 reference statements)

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“…For example, the establishment of a population (screening) plan, the establishment of standardized diagnostic methods and targeted preventive measures specifically for pregnancy-associated breast cancer. 36…”

Section: Discussionmentioning

confidence: 99%

<p>ANLN Directly Interacts with RhoA to Promote Doxorubicin Resistance in Breast Cancer Cells</p>

Wang

Xiang

Huang

et al. 2020

CMAR

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Background: Chemotherapy resistance is the leading cause of cancer treatment failure. This research was conducted to explore a potential link between actin-binding protein anillin (ANLN) and doxorubicin resistance in breast cancer. Materials and Methods: We compared ANLN expression and 50% inhibition concentration (IC50) of doxorubicin in human breast cancer cells (MDA-MB-231) and human breast cancer cells with doxorubicin resistance (MDA-MB-231/ADM). Co-immunoprecipitation was used to investigate the interaction between ANLN and RhoA. The cell viability, apoptosis, gene and protein expression were estimated by MTT, flow cytometry, quantitative real-time PCR and western blot. Results: The doxorubicin resistance in MDA-MB-231/ADM cells (IC50 = 19.40 ± 1.16 μg/ mL) was significantly higher than that in MDA-MB-231 cells (IC50 = 1.65 ± 0.23 μg/mL). ANLN was up-regulated in MDA-MB-231/ADM cells compared to MDA-MB-231 cells. Furthermore, ANLN overexpression promoted cell viability and inhibited apoptosis of MDA-MB-231 cells. The gene and protein expression of multidrug resistance (MDR1) and cancer resistance protein (BCRP) were enhanced by ANLN overexpression in MDA-MB-231 cells. ANLN silencing suppressed cell viability and the expression of MDR1 and BCRP and facilitated apoptosis in MDA-MB-231/ADM cells. Moreover, ANLN promoted RhoA activation by interacting with RhoA. ANLN up-regulation enhanced cell viability and the expression of MDR1 and BCRP and decreased apoptosis of MDA-MB-231 cells. The influence conferred by ANLN overexpression was effectively abolished by C3 transferase. Conclusion: This work revealed that ANLN promoted doxorubicin resistance in breast cancer cells by activating RhoA. Thus, our study suggests a novel target for breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

<p>ANLN Directly Interacts with RhoA to Promote Doxorubicin Resistance in Breast Cancer Cells</p>

Wang

Xiang

Huang

et al. 2020

CMAR

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“…Consequently, well-designed clinical trials are needed to establish optimal conditions and individualized treatment algorithms for the cost-effective and readily applicable chemoprevention by dietary phytochemicals. In order to reach the goal, multi-professional expertise is essential to explore, create, and implement a comprehensive approach based on the multiomic diagnostics [ 214 , 215 ], individualized patient profiling [ 216 , 217 ], patient stratification by phenotyping and genotyping [ 218 , 219 ], disease modelling, and machine learning [ 220 ] as well as innovative screening programs linked to the targeted preventive measures [ 221 , 222 ]. Current article conforms to the principles of predictive, preventive, and personalized medicine as the medicine of the future [ 223 ].…”

Section: Conclusion and Expert Recommendationsmentioning

confidence: 99%

Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention

Kapinová

Kubatka

Golubnitschaja

et al. 2018

Environ Health Prev Med

154

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Cancerous tissue transformation developing usually over years or even decades of life is a highly complex process involving strong stressors damaging DNA, chronic inflammation, comprehensive interaction between relevant molecular pathways, and cellular cross-talk within the neighboring tissues. Only the minor part of all cancer cases are caused by inborn predisposition; the absolute majority carry a sporadic character based on modifiable risk factors which play a central role in cancer prevention. Amongst most promising candidates for dietary supplements are bioactive phytochemicals demonstrating strong anticancer effects. Abundant evidence has been collected for beneficial effects of flavonoids, carotenoids, phenolic acids, and organosulfur compounds affecting a number of cancer-related pathways. Phytochemicals may positively affect processes of cell signaling, cell cycle regulation, oxidative stress response, and inflammation. They can modulate non-coding RNAs, upregulate tumor suppressive miRNAs, and downregulate oncogenic miRNAs that synergically inhibits cancer cell growth and cancer stem cell self-renewal. Potential clinical utility of the phytochemicals is discussed providing examples for chemoprevention against and therapy for human breast cancer. Expert recommendations are provided in the context of preventive medicine.

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“…As detailed above, chemopreventive strategies play an important role in the context of 3P medicine [229]. However, further research for determining active compounds and dosing selection is urgently warranted to effectively promote their clinical implementation in terms of primary and secondary chemoprevention as well as cancer management as a whole [230][231][232].…”

Section: Concluding Remarks Expert Recommendations and Outlookmentioning

confidence: 99%

Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

et al. 2020

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Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.

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Pregnancy-associated breast cancer: the risky status quo and new concepts of predictive medicine

Cited by 45 publications

References 120 publications

<p>ANLN Directly Interacts with RhoA to Promote Doxorubicin Resistance in Breast Cancer Cells</p>

<p>ANLN Directly Interacts with RhoA to Promote Doxorubicin Resistance in Breast Cancer Cells</p>

Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention

Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

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