Pregnancy-associated plasma protein A: Circulating levels during normal pregnancy

Folkersen, J.; Grudzinskas, J. G.; Hindersson, Peter; Teisner, B.; Westergaard, J.G.

doi:10.1016/0002-9378(81)90957-1

Cited by 102 publications

(31 citation statements)

References 10 publications

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“…Moreover, PAPPA is secreted into the maternal circulation (Folkersen et al 1981), and can be a useful marker for certain diseases and pregnancy complications. For example, unusually low levels of PAPPA in the first trimester may be indicative of increased risk of fetal genetic disorders such as Down's syndrome (Brambati et al 1993) and Cornelia de Lange syndrome (Aitken et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse

Wang¹,

Qiu²,

Haider³

et al. 2009

Journal of Endocrinology

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Pregnancy-associated plasma protein-A and -A2 (PAPPA and PAPPA2) are proteases that cleave IGF binding proteins (IGFBPs) and thereby increase the bioavailability of growth factors. PAPPA has long been recognized as a marker of fetal genetic disorders and adverse pregnancy outcomes. In contrast, although PAPPA2 is also highly expressed in human placenta, its physiological importance is not clear. To establish whether mice will be a useful model for the study of PAPPA2, we compared the patterns of expression of PAPPA2 in the placentae of mouse and human. We show, for the first time, that Pappa2 is highly expressed in mouse placenta, as is the case in humans. Specifically, it is expressed at the interface of the maternal and fetal layers of the mouse placenta at all gestational stages studied (10 . [5][6][7][8][9][10][11][12][13][14][15][16] . 5 days post coitum).Similarly, PAPPA2 is expressed in the syncytiotrophoblast layer of human placental villi and is also detected in some invasive extravillous trophoblasts in the first trimester. These results are consistent with a model whereby PAPPA2 cleaves IGFBPs produced in the maternal decidua to promote fetoplacental growth, and indicate that this protein may play analogous roles in human and mouse placenta. PAPPA2 protein is detectable in the circulation of pregnant mice and humans during the first trimester and at term, raising the possibility that PAPPA2 may be a useful biomarker of placental dysfunction. Pappa2 expression also shows specific localization within the mouse embryo and therefore may play roles in fetal development, independent of its action in the placenta.

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Section: Introductionmentioning

confidence: 99%

Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse

Wang¹,

Qiu²,

Haider³

et al. 2009

Journal of Endocrinology

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“…The concentration in serum reaches about 50 mg/liter at the end of pregnancy (2,3). PAPP-A was originally characterized as a high molecular weight homotetramer (1,4,5), but it has now been demonstrated that PAPP-A exists in pregnancy serum as a covalent, heterotetrameric 2:2 complex with the proform of eosinophil major basic protein (proMBP), PAPP-A/proMBP (6).…”

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confidence: 99%

Expression of Recombinant Human Pregnancy-associated Plasma Protein-A and Identification of the Proform of Eosinophil Major Basic Protein as Its Physiological Inhibitor

Overgaard¹,

Haaning²,

Boldt³

et al. 2000

Journal of Biological Chemistry

169

160

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“…During pregnancy, PAPP-A is synthesized and released by the syncytiotrophoblast and maternal serum PAPP-A levels increase throughout pregnancy [15]. PAPP-A is thought to promote growth and development of the placenta by increasing local bioavailability of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) [16,17].…”

Section: Discussionmentioning

confidence: 99%

732: First trimester PAPP-A levels correlate with sFlt-1 levels longitudinally in pregnant women with and without preeclampsia

Saxena

Seely

Rich‐Edwards

et al. 2012

American Journal of Obstetrics and Gynecology

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Pregnancy-associated plasma protein A: Circulating levels during normal pregnancy

Cited by 102 publications

References 10 publications

Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse

Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse

Expression of Recombinant Human Pregnancy-associated Plasma Protein-A and Identification of the Proform of Eosinophil Major Basic Protein as Its Physiological Inhibitor

732: First trimester PAPP-A levels correlate with sFlt-1 levels longitudinally in pregnant women with and without preeclampsia

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