Pregnancy-Associated α₂-Glycoprotein in Rheumatoid Arthritis

Abstract

Pregnancy-associated α₂-glycoprotein (PAG) was found to be increased in sera and synovial fluids of patients suffering from rheumatoid arthritis tested in the single radial immunodiffusion. The PAG levels in rheumatoid sera correlated well with the activity of arthritis in the patients. The purified PAG inhibited clearly the ³H-thymidine uptake of normal lymphocytes stimulated with phytohemagglutinin and also the spontaneous attachment of sheep erythrocytes to normal lymphocytes. 17 of 19 rheumatoid plasmas inhibited the ³H-thymidine uptake of normal lymphocytes and intensity of their inhibitory effects correlated with serum PAG levels.

Schwangerschaftsassoziiertes Alpha-2-Glycoprotein (alpha2-PAG) in der Differentialdiagnose der chronischen Polyarthritis und reaktiven Arthritis

“…Wenn auch die individuellen Werte sich nicht verändern, es ist doch bei Patienten mit schwereren Verlaufsformen einer chron. Polyarthritis mit höheren 0'2-PAG-Werten zu rechnen als bei solchen mit milderen (19).…”