Pregnancy Following Removal of Both Ovaries and Tubes

Morris, M. A.

doi:10.1056/nejm190101241440405

Cited by 10 publications

(5 citation statements)

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“…Using Zuckerman’s reasoning [11], the dogma of a fixed pool of oocytes being set forth at birth would be invalidated simply by scientific evidence inconsistent with the idea that this population of germ cells is not subject to renewal in postnatal life. As discussed above, such evidence clearly existed [3,4,5,6,7,8,9,10,15,16,17], but was still discounted.…”

Section: Introduction: a Brief History Of Postnatal Oogenesis In Mmentioning

confidence: 98%

“…One of the earliest reports on this subject was published in the late 1800s by Wilhelm von Waldeyer-Hartz, a German anatomist who hypothesized based on histological surveys that no additional oocytes were produced in the ovaries after the perinatal period [2]. Although subsequent studies in the early 1900s generated evidence that countered this belief [3,4,5,6,7,8,9,10], the prevailing view in the field remained mostly in alignment with Waldeyer’s earlier opinion. After more than 5 decades of scientific inquiry and discussion, this debate came to an abrupt halt in 1951, when Zuckerman concluded from his review of the scientific literature at the time that oocyte formation does, in fact, irreversibly cease by the time of birth [11].…”

Section: Introduction: a Brief History Of Postnatal Oogenesis In Mmentioning

confidence: 99%

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Implications and Current Limitations of Oogenesis from Female Germline or Oogonial Stem Cells in Adult Mammalian Ovaries

Martin

Woods

Tilly

2019

Cells

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A now large body of evidence supports the existence of mitotically active germ cells in postnatal ovaries of diverse mammalian species, including humans. This opens the possibility that adult stem cells naturally committed to a germline fate could be leveraged for the production of female gametes outside of the body. The functional properties of these cells, referred to as female germline or oogonial stem cells (OSCs), in ovaries of women have recently been tested in various ways, including a very recent investigation of the differentiation capacity of human OSCs at a single cell level. The exciting insights gained from these experiments, coupled with other data derived from intraovarian transplantation and genetic tracing analyses in animal models that have established the capacity of OSCs to generate healthy eggs, embryos and offspring, should drive constructive discussions in this relatively new field to further exploring the value of these cells to the study, and potential management, of human female fertility. Here, we provide a brief history of the discovery and characterization of OSCs in mammals, as well as of the in-vivo significance of postnatal oogenesis to adult ovarian function. We then highlight several key observations made recently on the biology of OSCs, and integrate this information into a broader discussion of the potential value and limitations of these adult stem cells to achieving a greater understanding of human female gametogenesis in vivo and in vitro.

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Section: Introduction: a Brief History Of Postnatal Oogenesis In Mmentioning

confidence: 98%

Section: Introduction: a Brief History Of Postnatal Oogenesis In Mmentioning

confidence: 99%

Implications and Current Limitations of Oogenesis from Female Germline or Oogonial Stem Cells in Adult Mammalian Ovaries

Martin

Woods

Tilly

2019

Cells

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“…The simple observation that unilateral ovariectomy or incomplete total ovariectomy leads to a compensatory hypertrophy of the remaining tissue has led to a long series of researches which, often incidentally, form the basis for our modern knowledge of the elements of ovarian dynamics. The fact that such hypertrophy occurs was originally established both clinically (Robertson, 1890; 1896; Sutton, 1896; Morris, 1901;Doran, 1902;Kynoch, 1902; and Meredith, 1904) and experimentally (Kanel, 1901;Bond, 1906; Carmichael and Marshall, 1908). An almost exact doubling of weight in the remaining ovary of unilaterally ovariectomized rats has been reported by Stotsenburg (1913) and Hatai (1913Hatai ( , 1915 and the number of eggs shed is demonstrably equal to the number normally produced by two ovaries (see Lipschiitz, 1924; Hanson and Boone, 1926;Crew, 1927;and Slonaker, 1927).…”

Section: The Experimental Investigation Of the Growth Of Egg Cellsmentioning

confidence: 99%

The eggs of mammals, by Gregory Pincus ...

Pincus¹

1936

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The hving egg was neglected presumably because no technique was developed for preserving it intact in vitro long enough for any extensive experimentation to be performed. Nor did the possibility of experimental manipulation of ova in vivo receive more than passing attention (see Grusdew, 1896; Novak and Eisinger, 1923). Since the pubhcation of Stockard and Papanicolou's (1917) and Long and Evans' (1922) exhaustive accounts of the oestrus cycle of the guinea pig and rat respectively, a new era in the study of sexual physiology has been initiated. Enormous strides have been made in the discovery and purification of the hormones regulating the activities of the genital tracts of mammals. The ovarian control of the various phases of the sex cycles in the female has received exhaustive attention, and the control of gonad function by the anterior pituitary has been investigated in detail. Despite the enormous accumulation of data on the endocrine regulation of the ovarian and oviduct environment of ova, the ova them

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“…5 The idea that mammalian females are provided with a nonrenewable oocyte pool early in life is also inconsistent with published experimental data, not just from our recent work with mice, 15,16 but also from studies conducted 50 years ago with rhesus monkeys, 12 among many others. [1][2][3][4][5][7][8][9][10][11]13 In this latter study, Vermande-Van Eck provided several key observations that allow unambiguous mathematical modeling of ovarian lifespan in non-human primates. 12 First, in-depth histomorphometric analysis of ovaries from three independent groups of female monkeys at or just after puberty, which in the rhesus monkey occurs between 2.5-3.5 years of age, 56 revealed on average approximately 58,000 oocytes per ovary.…”

mentioning

confidence: 99%

“…In fact, several investigators had independently concluded around the time of the work of Pearl and Schoppe with birds 2 that ovaries regenerate during adulthood in several species of mammals, including mice, rats and humans, following ovariectomy. 4,[8][9][10] Nonetheless, Zuckerman's efforts in 1951 to once and for all settle this debate in favor of a fixed reserve of oocytes at birth proved for the most part successful, despite continuing but short-lived opposition by some. [11][12][13] www.landesbioscience.com Cell Cycle…”

mentioning

confidence: 99%

Setting the Record Straight on Data Supporting Postnatal Oogenesis in Female Mammals

Johnson

Skaznik-Wikiel²,

Ho-Joon³

et al. 2005

Cell Cycle

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Of all the 'certainties' in mammalian female reproductive biology, the concept that a non-renewing oocyte reserve is set forth in the ovaries at birth may be the most longstanding and widely held. However, when data from our studies of oocyte apoptosis unintentionally began to contradict this theory in the latter part of 2002, we embarked on an investigation, unbiased by any pre-conceived dogmas, to determine if oocyte production persists in adult female mice. In 2004, we presented our first experimental findings in the journal Nature, which indicated that oogenesis indeed continues in adulthood. Amidst widespread skepticism, we moved forward with our studies and this year published our follow-up experiments in the journal Cell. Results from this latter body of work not only reinforced our earlier conclusions but also identified bone marrow as a surprising source of oocyte-producing germ cells in adults. Although this study has also been met with skepticism, doubts raised in commentaries on our work are largely based on inaccurate or incomplete assessments of our experimental models and results. Here we have attempted to clarify published misperceptions and misinterpretations of our data, and offer additional insights that challenge the idea of fixed endowment of oocytes at birth.

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Pregnancy Following Removal of Both Ovaries and Tubes

Cited by 10 publications

References 0 publications

Implications and Current Limitations of Oogenesis from Female Germline or Oogonial Stem Cells in Adult Mammalian Ovaries

Implications and Current Limitations of Oogenesis from Female Germline or Oogonial Stem Cells in Adult Mammalian Ovaries

The eggs of mammals, by Gregory Pincus ...

Setting the Record Straight on Data Supporting Postnatal Oogenesis in Female Mammals

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