Pregnancy following uterine fibroid embolization

McLucas, Bruce; Goodwin, Scott C.; Adler, Louis; Rappaport, Aviva I; Reed, Richard A.; Perrella, R R

doi:10.1016/s0020-7292(01)00405-2

Cited by 149 publications

(76 citation statements)

References 27 publications

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“…Advice often given to women with uterine fibroids who desire to retain fertility is to avoid UAE. Pregnancy after UAE has been described in the literature in the form of case reports, and a review article, 6 some retrospective series [7][8][9] and one retrospective cohort study comparing UAE with laparoscopic myomectomy. 10 In December 1996, a prospective observational study was established to evaluate UAE in the management of symptomatic uterine fibroids.…”

mentioning

confidence: 99%

Pregnancy after uterine artery embolization for leiomyomata: A series of 56 completed pregnancies

Walker

McDowell

2006

American Journal of Obstetrics and Gynecology

153

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mentioning

confidence: 99%

Pregnancy after uterine artery embolization for leiomyomata: A series of 56 completed pregnancies

Walker

McDowell

2006

American Journal of Obstetrics and Gynecology

153

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“…O relato da evolução de nossos casos é semelhante a várias descrições de séries com gravidezes e partos em mulheres submetidas a embolização arterial [12][13][14][15][16] .…”

Section: Discussionunclassified

“…Quanto aos resultados de gestações, não se observa aumento signifi cativo nas complicações durante a gravidez, no parto e no puerpério, sendo concorde com o relato do nosso primeiro caso [12][13][14]16 . É relatada uma freqüência signifi cante de partos normais, em comparação com mulheres submetidas a miomectomia, sem aumento nas complicações, como rotura uterina 13,14 .…”

Section: Discussionunclassified

Gravidez e parto após embolização arterial para tratamento de leiomioma uterino

Bonduki

Gonçalves

Yokohama

et al. 2006

Rev. Bras. Ginecol. Obstet.

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RESUMOObjetivo: Analisar a evolução da gestação e partos após tratamento de leiomioma uterino por embolização das artérias uterinas. Métodos: Foram incluídas na avaliação inicial 112 pacientes submetidas a embolização de artérias uterinas para tratamento de mioma uterino. Destas, somente nove desejavam o tratamento conservador para manter a capacidade reprodutiva. Este procedimento foi indicado para estas nove pacientes, pois elas não eram susceptíveis ao tratamento conservador cirúrgico. Submeteram-se a embolização das artérias uterinas com partículas de álcool polivinílico ou embosferas com diâmetro de 500 a 700 µm e evoluíram sem intercorrências. Resultados: Durante o acompanhamento dessas nove pacientes houve boa resposta clínica, com redução signifi cativa no volume do útero e dos miomas. Dessas nove, quatro engravidaram, sendo que duas tiveram abortamento precoce e duas evoluíram normalmente até o fi nal da gestação com parto a termo, sendo um deles gemelar. Conclusão: A embolização de artérias uterinas é uma opção para o tratamento de miomas uterinos e apresenta bons resultados clínicos e anatômicos, permitindo manter a capacidade reprodutiva. PALAVRAS-CHAVE:Mioma; Neoplasias uterinas; Leiomioma/terapia; Embolização terapêutica/métodos; Fertilidade; Gravidez ABSTRACT Purpose: To analyze gestation evolution and deliveries after myoma treatment by embolization of the uterine arteries. Methods: In the initial evaluation, 112 patients submitted to embolization of uterine arteries were included for treatment of myoma. From those, only nine wanted to be submitted to conservative treatment in order to keep their reproductive capacity. This procedure was indicated to the nine patients, since they were not susceptible to a conservative surgical treatment. They were submitted to embolization of the uterine arteries with particles of polyvinyl alcohol or embospheres with diameters ranging from 500 to 700 µm, and they have evolved without intercurrence. Results: During the follow-up of these patients, there was a good clinical response with signifi cant reduction in the uterus and myoma volumes. Four of them got pregnant, two had an early abortion and two evolved normally till the end of gestation with a term delivery. One of these had twins. Conclusion: Embolization of the uterine arteries is an option for the treatment of uterine myoma, and presents good clinical and anatomical results, allowing patients to preserve their reproductive capacity.

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“…Uterine artery embolization (UAE) is a minimally invasive technique, first reported by Ravina and colleagues in 1995 [2] and consistently proven to be an effective treatment of symptomatic uterine leiomyoma by many following studies [3][4][5]. Recently, it also has been suggested as an alternative treatment to hysterectomy and myomectomy [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…However, it is still controversial whether UAE is safe for patients ho desire future fertility [3][4][5][11][12][13][14][15]. The effect of UAE remains unclear due to the ethical difficulty in conducting prospective studies on human fertility.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study of Uterine Artery Embolization with Tris-Acryl Gelatin Microspheres in Guinea Pigs

Zhou

Tan

Guo

et al. 2011

Cardiovasc Intervent Radiol

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Objective This study was designed to establish guinea pigs as an animal model for uterine artery embolization (UAE) with tris-acryl gelatin microspheres (TAGM). Methods Twenty-five female adult guinea pigs were randomly divided into two groups, including a uterine artery casting mould group (n = 10) and a UAE group (n = 15). Pelvic angiography and vascular casting mould were performed in the first group. The anatomical characters of the pelvic cavity in guinea pigs were described. In the second group, the technical feasibility of performing UAE with TAGM in guinea pigs was investigated. The histopathological slides of the uterus of guinea pigs after UAE were examined to inspect the outcomes of UAE. Results The uterine artery springs from the internal iliac artery, ascends tortuously along the cervix, and gives off vertically 8-10 branches to the cervix uteri and uterine horns. The diameters of the trunk of the uterine artery and its first branch were 0.32 ± 0.027 mm and 0.14 ± 0.01 mm, respectively. For UAE animals, the dosages of 40-120 and 100-300 lm TAGM were 0.033 ± 0.003 ml and 0.015 ± 0.002 ml, respectively. On histopathological slides, embosphere particles were found in the first branches of the uterine artery, the subserous arteries, and the intramural arteries. Inflammatory reactions in the uterus were common in guinea pigs after UAE. Local or dispersed areas of necrosis in uterus also were observed in a few guinea pigs. Conclusions Guinea pigs are an appropriate and feasible model for UAE with TAGM.

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Pregnancy following uterine fibroid embolization

Cited by 149 publications

References 27 publications

Pregnancy after uterine artery embolization for leiomyomata: A series of 56 completed pregnancies

Pregnancy after uterine artery embolization for leiomyomata: A series of 56 completed pregnancies

Gravidez e parto após embolização arterial para tratamento de leiomioma uterino

A Pilot Study of Uterine Artery Embolization with Tris-Acryl Gelatin Microspheres in Guinea Pigs

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