Pregnancy in papillary thyroid cancer survivors

Beksaç, Kemal; Aktoz, Fatih; Örgül, Gökçen; Ht, Çelik; Özgü-Erdinç, A. Seval; Beksac, Mehmet Sinan

doi:10.4274/jtgga.2017.0057

Cited by 8 publications

(2 citation statements)

References 25 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several retrospective studies have discussed the effects of a history of thyroid cancer on obstetric outcomes. [7][8][9] However, no studies have investigated the concurrent thyroid function status of this population. In addition, the previous studies reported conflicting results regarding the risks of postpartum hemorrhage, pre-eclampsia, and preterm birth.…”

Section: Introductionmentioning

confidence: 99%

“…Whether the abnormal thyroid functions of these patients would influence obstetric outcomes remains unclear and needs to be addressed. Several retrospective studies have discussed the effects of a history of thyroid cancer on obstetric outcomes 7–9 . However, no studies have investigated the concurrent thyroid function status of this population.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Obstetric outcomes in thyroid cancer survivors: A retrospective cohort study

Liu

Yuan

Zhao

et al. 2021

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Objective To investigate whether thyroid cancer survivors would have increased risks of adverse obstetric outcomes. Methods Data from 154 women with a history of thyroid cancer who had a live birth at Peking University Third Hospital from January 2012 to December 2019 were collected. The control group consisted of 308 women without any thyroid disease or malignant tumor. Age and year of delivery were matched between the two groups. Results Serum levels of thyroid stimulating hormone and free thyroxine were significantly lower and higher in thyroid cancer patients, respectively (P < 0.001). After adjusting for age, pre‐pregnancy body mass index, pre‐pregnancy hypertension, pre‐pregnancy diabetes mellitus, previous cesarean section, and conception by in vitro fertilization/intracytoplasmic injection, adverse obstetric outcomes including preterm birth (odds ratio [OR] 0.73, 95% confidence interval [CI] 0.32–1.67), low birth weight infant (OR 1.05, 95% CI 0.44–2.50), gestational diabetes mellitus (OR 0.86, 95% CI 0.54–1.39), and pre‐eclampsia (OR 1.11, 95% CI 0.34–3.57) showed no differences between thyroid cancer survivors and the control group. However, pregnant women with a history of thyroid cancer had a higher risk of abnormally invasive placentation (OR 10.57, 95% CI 1.22–91.97, P = 0.032). Conclusion Although the thyroid function status of thyroid cancer patients was different from that of pregnant women without any thyroid disease or malignancy, they would not be at a higher risk of most adverse obstetric outcomes except for abnormally invasive placentation.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Obstetric outcomes in thyroid cancer survivors: A retrospective cohort study

Liu

Yuan

Zhao

et al. 2021

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

A narrative review of pregnancy after malignancies in young women that don’t originate in the female genital organs or in the breast

Girardelli

Mangili

Cosio

et al. 2021

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

Pregnancy outcomes in papillary thyroid cancer survivors：A retrospective cohort study

Zuo

Yang

2022

gocm

View full text Add to dashboard Cite

ObjectiveThe purpose of this study was to evaluate the pregnancy outcomes among papillary thyroid cancer survivors.Methods65 cases singleton gravidas of papillary thyroid cancer survivors treated in the Department of Obstetrics, Peking University People's Hospital between January 2011 and January 2020 were selected retrospectively as the study group, and 130 cases of singleton pregnancy during the same time were randomly selected as the control group. The differences in general conditions, maternal and fetal complications between the two groups were analyzed. Risk factors of maternal complications and fetal malformation in patients with papillary thyroid cancer survivors were analyzed. Data was analyzed witht-test,χ2test and logistic regression for statistical differences.ResultsTotally 65 cases of papillary thyroid cancer with 70 pregnancies were analyzed, which including 65 cases achieved live birth, 5 cases underwent induced labor because of fetal malformation. The study group showed higher incidence in gestational diabetes(20% vs 10%), cesarean section(39.1% vs 24.6%), postpartum hemorrhage(350 ± 193 ml vs 290 ± 181 ml) and fetal malformation(5.7% vs 1.5%), and lower live birth rate(91.4% vs 99.2%) (P < 0.05). Multivariate analysis by logistic regression found that the patient's age, thyroid function, operation mode and postoperative I-131 treatment were not the risk factors which may affect the pregnancy outcomes or fetal malformation.ConclusionElevated maternal and fetal complications were observed among pregnancies in papillary thyroid cancer survivors. Management of these survivors may require a careful gestation monitoring, and further investigation is needed.

show abstract

Pregnancy in papillary thyroid cancer survivors

Cited by 8 publications

References 25 publications

Obstetric outcomes in thyroid cancer survivors: A retrospective cohort study

Obstetric outcomes in thyroid cancer survivors: A retrospective cohort study

A narrative review of pregnancy after malignancies in young women that don’t originate in the female genital organs or in the breast

Pregnancy outcomes in papillary thyroid cancer survivors：A retrospective cohort study

Contact Info

Product

Resources

About