Pregnancy in Women with Congenital Heart Disease: The Impact of a Systemic Right Ventricle

Jain, Vanita; Moghbeli, Nazanin; Webb, Gary D.; Srinivas, Sindhu K.; Elovitz, Michal A.; Paré, Emmanuelle

doi:10.1111/j.1747-0803.2011.00497.x

Cited by 21 publications

(14 citation statements)

References 32 publications

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“…4,5,9–11 In a study of 562 pregnant women with heart disease receiving care in 13 Canadian cardiac and obstetric teaching hospitals, Siu et al 10 found that composite cardiovascular outcome (pulmonary edema, arrhythmia, stroke, or cardiac death) complicated 13% of 617 pregnancies. Two other groups of researchers have utilized the Nationwide Inpatient Sample to determine associated outcomes among pregnant women with CHD; both studies primarily focused on cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

“…We also investigated a composite cardiovascular outcome because it was used in previous studies that included any one of the following: in-hospital mortality, myocardial infarction, cardiac arrest, arrhythmia, heart failure, or stroke. 10,11 …”

Section: Methodsmentioning

confidence: 99%

“…8 Previous studies in pregnant women with CHD have found rates of cardiac complications ranging from 11% to 19% as well as increased obstetric and neonatal complications in comparison with women without CHD. 4,5,9–11 At least two studies investigated the risk of cardiac morbidity and mortality during pregnancy for women with cardiac disease 10,11 taking into account prior cardiac events as well as echocardiographic results. These studies, however, have largely been limited to single academic centers and had small sample sizes.…”

mentioning

confidence: 99%

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Medical and Obstetric Outcomes Among Pregnant Women With Congenital Heart Disease

Thompson

Kuklina

Bateman

et al. 2015

Obstetrics &Amp; Gynecology

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OBJECTIVE To estimate nationwide trends in the prevalence of maternal congenital heart disease (CHD) and determine whether women with CHD are more likely than women without maternal CHD to have medical and obstetric complications. METHODS The 2000–2010 Nationwide Inpatient Sample was queried for International Classification of Diseases, 9th Revision, Clinical Modification codes to identify delivery hospitalizations of women with and without CHD. Trends in the prevalence of CHD were determined and then rates of complications were reported for CHD per 10,000 delivery hospitalizations. For Nationwide Inpatient Sample 2008–2010, logistic regression was used to examine associations between CHD and complications. RESULTS From 2000 to 2010, there was a significant linear increase in the prevalence of CHD from 6.4 to 9.0 per 10,000 delivery hospitalizations (P<.001). Multivariable logistic regression demonstrated that all selected medical complications, including mortality (17.8 compared with 0.7/10,000 deliveries, adjusted odds ratio [OR] 22.10, 95% confidence interval [CI] 13.96–34.97), mechanical ventilation (91.9 compared with 6.9/10,000, adjusted OR 9.94, 95% CI 7.99–12.37), and a composite cardiovascular outcome (614 compared with 34.3/10,000, adjusted OR 10.54, 95% CI 9.55–11.64) were more likely to occur among delivery hospitalizations with maternal CHD than without. Obstetric complications were also common among women with CHD. Delivery hospitalizations with maternal CHD that also included codes for pulmonary circulatory disorders had higher rates of medical complications compared with hospitalizations with maternal CHD without pulmonary circulatory disorders. CONCLUSION The number of delivery hospitalizations with maternal CHD in the United States is increasing, and although we were not able to determine whether correction of the cardiac lesion affected outcomes, these hospitalizations have a high burden of medical and obstetric complications.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Medical and Obstetric Outcomes Among Pregnant Women With Congenital Heart Disease

Thompson

Kuklina

Bateman

et al. 2015

Obstetrics &Amp; Gynecology

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show abstract

“…In contrast, codes for DiGeorge syndrome, Wiskott Aldrich syndrome, and X-linked agammaglobulinemia were more stable; the data attached to these cases is likely to be more reliable. The use of codes has been established in other recent studies: the assessment of rotavirus vaccination acute gastroenteritis [42], methicillin-resistant Staphylococcus aureus infections [43], outcomes of pregnancy in patients with congenital heart disease [44], risk of melanoma in rheumatoid arthritis [45], and drug induced acute liver toxicity [46]. In clinical immunology, ICD codes have been used to demonstrate that the use of intravenous immune globulin was associated with reduced risk of Alzheimer’s disease [47].…”

Section: Discussionmentioning

confidence: 99%

Examining the Use of ICD-9 Diagnosis Codes for Primary Immune Deficiency Diseases in New York State

et al. 2012

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Purpose To use International Classification of Disease Codes (ICD-9) codes to investigate primary immune deficiency (PID) in New York State. Methods We investigated the diagnosis of Primary Immune Deficiency (PID) in New York State (NYS) using the Statewide Planning and Research Cooperative System (SPARCS) database, a comprehensive data reporting system that collects ICD-9 codes for each patient hospitalized in NYS. Results From 2000–2004 there were 13,539,358 hospitalizations for 4,777,295 patients; of these, 2,361 patients (0.05 %) were diagnosed with one or more of the ICD-9 codes for PID. Antibody defects were the most common diagnoses made. The PID population had significantly more Caucasians, and fewer African American or Hispanic subjects compared to the general population. Subjects with PID codes were younger, had longer hospitalizations, were less likely to have Medicare and more likely to have Medicaid or Blue Cross insurance. Most hospitalizations were due to respiratory and infectious diseases. Most patients resided in the most populous counties, Kings, New York and Queens, but the distribution of home zip codes was not proportional to county populations. Conclusions These data provide useful information on incidence and complications of selected PID diagnoses in one large state.

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“…29 Supraventricular arrhythmias appear to be common, but significant decline in systemic ventricular function does not appear to occur in the short term related to pregnancy. 30 Successful pregnancy can be achieved in most women with TGA; however, the rate of fetal loss and maternal cardiovascular morbidity is increased.…”

Section: Ebstein Anomalymentioning

confidence: 96%

Pregnancy and Adult Congenital Heart Disease

Bhatt

Yeh

2015

Cardiology Clinics

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Pregnancy in Women with Congenital Heart Disease: The Impact of a Systemic Right Ventricle

Cited by 21 publications

References 32 publications

Medical and Obstetric Outcomes Among Pregnant Women With Congenital Heart Disease

Medical and Obstetric Outcomes Among Pregnant Women With Congenital Heart Disease

Examining the Use of ICD-9 Diagnosis Codes for Primary Immune Deficiency Diseases in New York State

Pregnancy and Adult Congenital Heart Disease

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