Pregnancy Induced Haemophagocytic Syndrome

Shukla, Anuj; Kaur, Amandeep; Hira, Harmanjit

doi:10.1007/s13224-011-0073-0

Cited by 26 publications

(27 citation statements)

References 6 publications

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“…There have only been a few reported cases of HPS during pregnancy with sometimes fatal fetal and maternal outcomes [5,[8][9][10][11][12][13][14][15][16][17][18][19]. According to the literature, the mean age for HPS onset during pregnancy is 31 yo and diagnosis is carried out at the second trimester (around 22 GA) [8,12,13,16,17,19,27,28].…”

Section: Hps Diagnosismentioning

confidence: 99%

Hemophagocytic syndrome in pregnancy: case report, diagnosis, treatment, and prognosis

Rousselin

Alavi

Moigne

et al. 2017

Clinical Case Reports

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Section: Hps Diagnosismentioning

confidence: 99%

Hemophagocytic syndrome in pregnancy: case report, diagnosis, treatment, and prognosis

Rousselin

Alavi

Moigne

et al. 2017

Clinical Case Reports

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“… 10 , 14 , 17 The remaining three cases had complete remission following delivery of the fetus. 15 , 16 , 18 These cases seem to imply that pregnancy itself is a major contributor to the development of HLH. Such assumption may be weak due to the rarity of HLH in pregnancy.…”

Section: Discussionmentioning

confidence: 98%

Idiopathic Hemophagocytic Lymphohistiocytosis during Pregnancy Treated with Steroids

et al. 2015

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Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe clinical syndrome characterized by a dysregulated hyperinflammatory immune response. The diagnosis of HLH during pregnancy is especially challenging due to the rarity of this condition. The highly variable clinical presentation, laboratory findings, and associated diagnoses accompanying this syndrome further complicate the problem. A pronounced hyperferritinemia in the setting of systemic signs and symptoms along with a negative infectious and rheumatological workup should raise suspicions for HLH. While treatment ideally consists of immunosuppressive chemotherapy and hematopoietic stem cell transplant, the potential toxicity to both the pregnant woman and the fetus poses a challenging decision. We report the first case of idiopathic HLH presenting as fever of unknown origin in a pregnant woman successfully treated with steroids.

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“…The pathogenesis of pregnancy as a trigger for HLH is currently not well understood but multiple theories have been proposed [ 15 - 19 ]. One theory is that the immature placenta releases trophoblastic debris with fetal RNA and DNA components into maternal circulation, leading to a systemic inflammatory response [ 16 , 17 ]. Osugi et al in 1997 hypothesized that an abnormal increase in Th1/Th2 ratio that can happen during pregnancy leads to macrophage activation and hemophagocytosis [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Recurrent Pregnancy-Induced Adult Onset Familial Hemophagocytic Lymphohistiocytosis

Wang

Ramsingh

et al. 2018

World J Oncol

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Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal disease primarily of children, characterized by a severe hyperinflammatory state. We describe a case of adult onset familial HLH with a novel exon 19, c.1607G>T (p.Arg536Leu) heterozygous mutation of the UNC13D gene in a 40-year-old woman who developed HLH during her first and second pregnancies, both episodes occurring during the first trimester. Our patient was treated successfully both times with HLH-94 protocol following spontaneous abortions and is currently in the process of getting a bone marrow transplant. We also discuss pregnancy as a potential trigger for late onset familial HLH.

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Pregnancy Induced Haemophagocytic Syndrome

Cited by 26 publications

References 6 publications

Hemophagocytic syndrome in pregnancy: case report, diagnosis, treatment, and prognosis

Hemophagocytic syndrome in pregnancy: case report, diagnosis, treatment, and prognosis

Idiopathic Hemophagocytic Lymphohistiocytosis during Pregnancy Treated with Steroids

A Case of Recurrent Pregnancy-Induced Adult Onset Familial Hemophagocytic Lymphohistiocytosis

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