Pregnancy interceptive activity of the roots of Calotropis gigantea Linn. in rats

Srivastava, Smriti; Keshri, Govind; Bhargavan, Biju; Singh, Chandan; Singh, Man Mohan

doi:10.1016/j.contraception.2006.11.010

Cited by 35 publications

(27 citation statements)

References 5 publications

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“…11,12 Traditionally, the root of Calotropis gigantea is used in treatment of leprosy, asthma, bronchitis, and as an expectorant. 13,14 Calotropis gigantea reported to exhibit free radical scavenging 15,16 and pro-coagulation activity, 17 pregnancy interceptive, 18 anticancer, 19 immunomodulatory, 20 wound healing, 21 anti-inflammatory [22][23][24][25] and hepatoprotective 16,26 activity.…”

Section: Introductionmentioning

confidence: 99%

Sub-Acute Toxicity Study of Calotropis gigantea Latex Extracts in Male Swiss Albino Mice

Sanyal¹,

Maity²,

Pradhan³

et al. 2016

Toxicol Forensic Med Open J

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Section: Introductionmentioning

confidence: 99%

Sub-Acute Toxicity Study of Calotropis gigantea Latex Extracts in Male Swiss Albino Mice

Sanyal¹,

Maity²,

Pradhan³

et al. 2016

Toxicol Forensic Med Open J

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“…Aerial parts of the plant have been reported to possess anti-diarrheal properties (6) and flowers are known for their analgesic activity (7). The roots of the plant have shown CNS activity (5) as well as pregnancy interceptive properties (8).…”

mentioning

confidence: 99%

Hepatoprotective effects of Calotropis gigantea extract against carbon tetrachloride induced liver injury in rats

Lodhi¹,

Singh²,

Pant³

et al. 2009

Acta Pharmaceutica

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Reactive oxygen species (ROS) are inevitably generated, due to the incomplete reduction of O 2 in electron transfer reactions, as byproducts of biological reactions. When ROS production is greater than the detoxification capacity of the cell, excessively generated ROS causes extensive damage to DNA, proteins and lipids and acts as a mediator of pro-inflammatory and carcinogenic events (1). To avoid redox imbalance and oxidative damage, aerobic organisms possess efficient biochemical defense systems such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) (2), though it cannot completely protect them from severe oxidative stress. In this context, many scientists have tried to obtain dietary antioxidants such as ascorbate, tocopherol and carotenoids from fruits and vegetables, because they could help protect cells from cellular damage caused by oxidative stress.Several experimental animal models of hepatotoxicity have been developed to investigate the toxicological mechanisms between environmental contaminants and liver. Ethanolic extract (50 %) of stems of Calotropis gigantea R. Br. (Asclepiadaceae) at doses of 250 and 500 mg kg -1 were studied for hepatoprotective activity in male Wistar rats with liver damage induced using carbon tetrachloride, 2 mL kg -1 twice a week. The protective effect of C. gigantea extract was compared with the standard drug silymarin. Various biochemical parameters such as aspartate amino transferase (AST), alanine amino transferase (ALT), glutathione (GSH), lipid peroxide (LPO), superoxidedismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were evaluated. The results revealed that the C. gigantea extract significantly decreased AST, ALT (p < 0.001) and lipid peroxide (p < 0.01) levels. The antioxidant parameters GSH, GPx, SOD and catalase levels were increased considerably compared to their levels in groups not treated with C. gigantea extract.

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“…Chloroform soluble fraction at a dose of 200 mg/kg shown 100% activity in single day but other fractions were not active at 100 mg/kg. About 7-25% loss in body weight was noted for minimum effective contraceptive dose in the groups treated with extract and with chloroform soluble fraction when compared to that of the control group and they lack oestrogen agonist and antagonist activity at their minimum effective doses in ovariectomised immature rat bio-assay (Srivastava et al, 2007). Similarly crude and ethanolic root extract at a dose of 150 and 300 mg/kg were tested for the antifertility and ovaro-utero toxic effects.…”

Section: Contraceptive Activitymentioning

confidence: 99%

Calotropis gigantiea (L.) R. Br (Apocynaceae): A phytochemical and pharmacological review

Kadiyala

Ponnusankar

Elango

2013

Journal of Ethnopharmacology

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Pregnancy interceptive activity of the roots of Calotropis gigantea Linn. in rats

Cited by 35 publications

References 5 publications

Sub-Acute Toxicity Study of Calotropis gigantea Latex Extracts in Male Swiss Albino Mice

Sub-Acute Toxicity Study of Calotropis gigantea Latex Extracts in Male Swiss Albino Mice

Hepatoprotective effects of Calotropis gigantea extract against carbon tetrachloride induced liver injury in rats

Calotropis gigantiea (L.) R. Br (Apocynaceae): A phytochemical and pharmacological review

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