2011
DOI: 10.1371/journal.pone.0024101
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Pregnancy, Microchimerism, and the Maternal Grandmother

Abstract: BackgroundA woman of reproductive age often harbors a small number of foreign cells, referred to as microchimerism: a preexisting population of cells acquired during fetal life from her own mother, and newly acquired populations from her pregnancies. An intriguing question is whether the population of cells from her own mother can influence either maternal health during pregnancy and/or the next generation (grandchildren).Methodology/Principal FindingsMicrochimerism from a woman's (i.e. proband's) own mother (… Show more

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Cited by 30 publications
(39 citation statements)
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“…In the same study, MP microchimerism was not detected in preeclampsia, a pregnancy disorder thought by some to reflect maternal immune dysfunction. 24 It is unknown whether MP microchimerism plays an active role in, or reflects, the capacity for maternal adaptation to pregnancy, but further investigation of these questions has the potential to identify biomarkers and/or targets for immune modulation in women with RM.…”
Section: Discussionmentioning
confidence: 99%
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“…In the same study, MP microchimerism was not detected in preeclampsia, a pregnancy disorder thought by some to reflect maternal immune dysfunction. 24 It is unknown whether MP microchimerism plays an active role in, or reflects, the capacity for maternal adaptation to pregnancy, but further investigation of these questions has the potential to identify biomarkers and/or targets for immune modulation in women with RM.…”
Section: Discussionmentioning
confidence: 99%
“…We found that MP microchimerism increased with increasing gestational age, with frequency of detection 0% (0/9) in the first trimester, 16% (3/19) in the second trimester, 29% (7/24) in the third trimester and 14% (4/28) postpartum. 24 …”
Section: Microchimerism In Recurrent Miscarriage Hs Gammill Et Almentioning
confidence: 99%
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“…[8][9][10][11][12] So far, RHD qPCR has been used primarily to detect RHD sequences in cell-free fetal DNA, present in maternal plasma during pregnancy to predict the D blood group status of the fetus, without invasive procedures to obtain fetal genetic material [13][14][15] and for determination of (paternal) RHD zygosity. 16 concentrations from 900 to 50 nM and 250 to 50 nM, respectively.…”
Section: Introductionmentioning
confidence: 99%
“…This "graft," acquired during fetal immune system development, contributes to aspects of immune tolerance, 14 can remain in her system into adulthood, and represents a preexisting inhabitant as she experiences pregnancy herself. 15 During subsequent pregnancies, new fetal sources of microchimerism are acquired and may interact with the previously acquired MP microchimerism. 16 To explore microchimerism in the setting of RM, we recently conducted a prospective cohort study to evaluate MP microchimerism in women with unexplained RM, both prior to conception and longitudinally across pregnancy.…”
mentioning
confidence: 99%