Pregnancy outcome after gestational exposure to terfenadine: A multicenter, prospective controlled study☆☆☆

Loebstein, Ronen; Lalkin, Arieh; Addis, Antonio; Costa, Anabella; Lalkin, Iona; Bonati, Maurizio; Koren, Gideon

doi:10.1016/s0091-6749(99)70074-6

Cited by 37 publications

(24 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3][4] In contrast, a Danish study based on data from a prescription database found an increased risk of spontaneous abortion associated with the use of clarithromycin. 5 Three studies using data from teratology information services failed to show a link between the use of quinolones and the risk of spontaneous abortion, [6][7][8] and an early Medicaid study showed an association with the use of metronidazole. 9 However, the studies were all limited by either small samples, or recall or indication bias.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Use of antibiotics during pregnancy and risk of spontaneous abortion

Muanda

Sheehy

Bérard

2017

CMAJ

117

View full text Add to dashboard Cite

BACKGROUND: Although antibiotics are widely used during pregnancy, evidence regarding their fetal safety remains limited. Our aim was to quantify the association between antibiotic exposure during pregnancy and risk of spontaneous abortion. METHODS:We conducted a nested case-control study within the Quebec Pregnancy Cohort (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009). We excluded planned abortions and pregnancies exposed to fetotoxic drugs. Spontaneous abortion was defined as having a diagnosis or procedure related to spontaneous abortion before the 20th week of pregnancy. The index date was defined as the calendar date of the spontaneous abortion. Ten controls per case were randomly selected and matched by gestational age and year of pregnancy. Use of antibiotics was defined by filled prescriptions between the first day of gestation and the index date and was compared with (a) non-exposure and (b) exposure to penicillins or cephalosporins. We studied type of antibiotics separately using the same comparator groups. RESULTS:After adjustment for potential confounders, use of azithromycin (adjusted odds ratio [OR] 1.65, 95% confidence interval [CI] 1.34-2.02; 110 exposed cases), clarithromycin (adjusted OR 2.35, 95% CI 1.90-2.91; 111 exposed cases), metronidazole (adjusted OR 1.70, 95% CI 1.27-2.26; 53 exposed cases), sulfonamides (adjusted OR 2.01, 95% CI 1.36-2.97; 30 exposed cases), tetracyclines (adjusted OR 2.59, 95% CI 1.97-3.41; 67 exposed cases) and quinolones (adjusted OR 2.72, 95% CI 2.27-3.27; 160 exposed cases) was associated with an increased risk of spontaneous abortion. Similar results were found when we used penicillins or cephalosporins as the comparator group. INTERPRETATION:After adjustment for potential confounders, use of macrolides (excluding erythromycin), quinolones, tetracyclines, sulfonamides and metronidazole during early pregnancy was associated with an increased risk of spontaneous abortion. Our findings may be of use to policy-makers to update guidelines for the treatment of infections during pregnancy.

show abstract

mentioning

confidence: 99%

“…9 However, the studies were all limited by either small samples, or recall or indication bias. [1][2][3][4][5][6][7][8][9] Studies of the risk of spontaneous abortion associated with tetracyclines and nitrofurantoin are lacking.…”

mentioning

confidence: 99%

Use of antibiotics during pregnancy and risk of spontaneous abortion

Muanda

Sheehy

Bérard

2017

CMAJ

117

View full text Add to dashboard Cite

show abstract

“…In a large scale, prospective cohort study, comparing 250 women exposed to metronidazole in the first trimester with a control group of 608 women similar in age, there was no difference between groups regarding the pregnancy data, major birth defects, and birth weights (40). In a (44,45). However, the treatment period in that study was short (1-14 doses).…”

Section: ) Antibioticsmentioning

confidence: 91%

Safety of drugs used in cases with ulcerative colitis during pregnancy and lactation

Kalkan¹,

Dağlı²

2012

Turk J Gastroenterol

View full text Add to dashboard Cite

“…In a prospective review of 200 patients treated with quinolones during pregnancy, Loebstein et al failed to show an increased risk of arthropathy demonstrated in animal studies [62]. There was no significant increased rate of spontaneous abortions, prematurity or birth weight in the treatment group.…”

Section: Antibioticsmentioning

confidence: 97%