Pregnancy Outcome Following Gestational Exposure to Organic Solvents

Khattak, Sohail; K-Moghtader, Guiti; McMartin, Kristen; Barrera, Maru; Kennedy, Debbie; Koren, Gideon

doi:10.1001/jama.281.12.1106

Cited by 148 publications

(85 citation statements)

References 12 publications

(13 reference statements)

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“…Risks of low birth weights and fetal malformations have been reported to increase with work-related contact of pregnant women to benzene and other organic solvents (Khattak et al, 1999, Chen et al, 2000.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Current understandings and perspectives on non-cancer health effects of benzene: A global concern

Bahadar

Mostafalou

Abdollahi

2014

Toxicology and Applied Pharmacology

220

128

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Section: Accepted Manuscriptmentioning

confidence: 99%

Current understandings and perspectives on non-cancer health effects of benzene: A global concern

Bahadar

Mostafalou

Abdollahi

2014

Toxicology and Applied Pharmacology

220

128

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“…Khattak S et al in a prospective study demonstrated that women exposed occupationally to organic solvents had a 13-fold risk of major malformations as well increased risk for miscarriages in previous pregnancies while working with organic solvents. (15) …”

Section: Organic Solventsmentioning

confidence: 99%

Environmental Factors Implicated in the Causation of Adverse Pregnancy Outcome

Triche

Hossain

2007

Seminars in Perinatology

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“…To our knowledge, this is the first study where the risk of congenital malformations in relation to occupational painting has been investigated by a register-based approach. Some previous studies have focused on maternal exposure to volatile organic compounds (VOC) and have shown an increased risk of congenital anomalies among the children (19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Risk of congenital malformations among children of construction painters in Denmark: a nationwide cohort study

Tougaard¹,

Bonde

Hougaard

et al. 2014

Scand J Work Environ Health

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Risk of congenital malformations among children of construction painters in Denmark: a nationwide cohort study by Tougaard NH, Bonde JP, Hougaard SK, Jørgensen KT This is the first register-based study investigating the risk of congenital malformations in relation to parental occupational painting. This cohort study included 3,444 children born to female construction painters, and we found that they were not at higher risk of malformations than other children. The data were thoroughly investigated through several supplementary analyses and the results are reassuring. Affiliation 175Original article Scand J Work Environ Health. 2015;41(2):175-183. doi:10.5271/sjweh.3472 Risk of congenital malformations among children of construction painters in Denmark: a nationwide cohort study Objectives Painters' occupational exposure is classified as a group 1 carcinogen by the International Agency for Research on Cancer (IARC). Previous studies have shown increased risk of congenital malformations among children of women exposed to organic solvents and paint emissions during pregnancy. In Denmark, women comprise half of those enrolled in vocational paint training. We investigated the association between maternal and paternal occupational painting, respectively, and the risk of congenital malformations among children.Methods National register data were used to link childbirths, malformations, and parental occupation. The cohort included >1 300 000 children born to occupationally active women in Denmark 1980-2010. Cases were hospital-diagnosed with malformations within the first year of life. Odds ratios (OR) with 95% confidence intervals (95% CI) were estimated using multiple logistic regression with adjustment for potential confounders.Results Among 3444 children of female construction painters, we found no increased risk of malformations overall (126 cases, OR 0.88, 95% CI 0.74-1.05) or in organ-specific subgroups compared to children of women in all other occupations (55 045 cases). Sensitivity analyses restricted to severe malformations, children of maternal painters with ≥2 years of pre-pregnancy exposure, and firstborn children, and analyses with maternal healthcare assistants and kitchen workers as reference supported the main results. Also, no associations were found when including diagnoses within the first 10 years of life, when stratifying by maternal age, birth year, and sex, or for paternal construction painters. ConclusionsThis nationwide cohort study is reassuring with no indications of increased risk of congenital malformations among children of male or of female construction painters.

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Pregnancy Outcome Following Gestational Exposure to Organic Solvents

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Cited by 148 publications

References 12 publications

Current understandings and perspectives on non-cancer health effects of benzene: A global concern

Current understandings and perspectives on non-cancer health effects of benzene: A global concern

Environmental Factors Implicated in the Causation of Adverse Pregnancy Outcome

Risk of congenital malformations among children of construction painters in Denmark: a nationwide cohort study

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