Pregnancy outcome in patients with ankylosing spondylitis

Tımur, Hakan; Tokmak, Aytekin; Türkmen, Gülenay Gençosmanoğlu; İnal, Hasan Ali; Uygur, Dilek; Danışman, Nuri

doi:10.3109/14767058.2015.1089432

Cited by 33 publications

(33 citation statements)

References 21 publications

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“…The rate of preeclampsia in our study was 7.7%, consistent with the current literature, and this rate was higher than the overall preeclampsia rate in the population, which is approximately 4.6% . Previously reported data from Turkey also reported similar obstetric outcomes for AS patients compared to a control group . Several other studies also reported no significant difference between pregnancies with AS and control groups .…”

Section: Discussionsupporting

confidence: 91%

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Retrospective evaluation of pregnancies with ankylosing spondylitis in a tertiary center in Turkey

et al. 2019

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Background To evaluate obstetrical and perinatal outcomes of pregnancies with ankylosing spondylitis (AS). Methods This was a retrospective study evaluating obstetric outcomes of 52 patients with AS who were followed up at our institution between 2006 and 2019. Patients were classified as having disease greater than or less than 5 years, and according to disease‐related medical treatment during pregnancy, as drug free, single medication or multiple medication. Results Overall rates of preterm delivery, intrauterine growth retardation and preeclampsia were 17.3%, 13.4% and 7.7%, respectively. Thirty‐three of the patients were followed up without any medication, while 19 patients used drugs during pregnancy. Seven patients used a single drug and 12 patients had multiple drugs. There was no significant difference in terms of obstetrical and neonatal outcomes. However, a higher rate of neonatal intensive care unit (NICU) admission was observed in the group using medication for AS, despite a lack of statistical significance (31.5% vs 15%, P = .162). On the other hand, patients having disease more than 5 years had higher rates of Apgar scores less than <7 and admission to the NICU despite a lack of statistical significance (4% vs 7.4% and 16% vs 26%; P = .267 and P = .297, respectively). Conclusion In conclusion, pregnancies of patients with AS must be considered as high risk due to increased rates of adverse outcomes such as preterm delivery, intrauterine growth retardation or preeclampsia.

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Section: Discussionsupporting

confidence: 91%

“…Some autoimmune diseases may be exacerbated during pregnancy. Most patients with AS conceive while their disease is active, unlike patients with rheumatoid arthritis, and generally pregnancy does not have a positive effect on the course of AS . Furthermore, AS was reported to be exacerbated in the postpartum period for most cases …”

Section: Introductionmentioning

confidence: 99%

Retrospective evaluation of pregnancies with ankylosing spondylitis in a tertiary center in Turkey

et al. 2019

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“…The results of the present study are in line with the aforementioned studies of AS and pregnancy. The previous retrospective case-control study with 20 pregnant women with AS demonstrated that pregnancy outcome of patients with AS was not different from that of healthy control subjects, except for older maternal age and higher rate of female foetuses in women with AS [17]. In addition, in the retrospective study involving 12 pregnant women with AS, pregnancy outcome was not significantly affected by the disease [18].…”

Section: Discussionmentioning

confidence: 90%

Pregnancy outcomes in Korean women with ankylosing spondylitis

Park

Lee

Kim

et al. 2021

Korean J Intern Med

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https://orcid.org/0000-0002-8029-7355 *These authors contributed equally to this work. Background/Aims: Because ankylosing spondylitis (AS) mainly affects sacroiliac joints, special attention should be given to normal labour and pregnancy outcomes. Here, we investigate pregnancy outcomes in Korean women with AS. Methods: Based on data from the Korean Health Insurance Review and Assessment Service claims database since July 2007, maternal complications were compared between women with AS and 1:10 matched general population by maternal age and year of delivery. Additionally, the 27 deliveries from 21 patients with AS who were seen at a tertiary hospital were retrospectively evaluated using 1:4 matched control group by maternal and gestational age. Results: In the population-based cohort, there were 1,293 deliveries in 996 patients with AS. Higher maternal age and more comorbidities were reported than in the general population. However, compared to age and delivery-year matched population, only the rate of Caesarean section (CS) was higher in women with AS (odds ratio, 1.52; 95% confidence interval, 1.36 to 1.70). Incidence of other maternal complications was comparable between women with AS and control subjects. In the hospital-based cohort, the CS rate was higher in women with AS (44.4% vs. 20.4%, p = 0.002). Causes of CS was not different in both groups, including previous uterine surgery. There were no significant differences in foetal outcomes, including growth restriction, foetal malformations and Apgar score. Conclusions: CS deliveries were performed more often in women with AS. However, other maternal complications and offspring complications were similar between women with AS and healthy control subjects.

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“…В единичных работах, посвященных анализу исходов беременности у пациенток с АС, превалирует мнение, что АС не оказывает отрицательного влияния на исходы беременности [15,16,25,26]. В обзоре M. Ostensen [25] впервые были суммированы результаты предыдущих исследований, касавшихся АС и беременности, и указано, что течение беременности у больных АС и здоровых женщин не различается, а роды проходят без осложнений.…”

Section: течение и исходы беременности при асunclassified

“…По данным H. Timur и совт. [26], описавших в 2016 г. 20 беременностей у пациенток с АС, неблагоприятных исходов не выявлено.…”

Section: течение и исходы беременности при асunclassified

Ankylosing spondylitis and pregnancy: a current view on the problem

Кричевская¹,

Гандалоева²,

Дубинина³

2018

RJTAO

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Ankylosing spondylitis (AS) more often develops in the 3rd and 4th decade of life when many women think about motherhood. Today, the view which has prevailed since the middle of the 20th century on AS as a male disease has been revised; the male to female ratio for this disease is approaching 1:1, which makes it urgent to study the problem of pregnancy in AS. The review gives the data available in the literature on fertility in AS, the interaction of the latter and pregnancy, and drug therapy during gestation. There is evidence for further investigations to clarify the course of AS, to optimize the assessment of its activity and patients' functional status, to identify markers for an exacerbation of the disease during pregnancy and after childbirth, and to standardize drug therapy when preparing for pregnancy and during the latter.

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Pregnancy outcome in patients with ankylosing spondylitis

Abstract: Women with AS have a favorable pregnancy outcome, and pregnancy does not substantially aggravate disease activity or severity in these patients.

Cited by 33 publications

References 21 publications

Retrospective evaluation of pregnancies with ankylosing spondylitis in a tertiary center in Turkey

Retrospective evaluation of pregnancies with ankylosing spondylitis in a tertiary center in Turkey

Pregnancy outcomes in Korean women with ankylosing spondylitis

Ankylosing spondylitis and pregnancy: a current view on the problem

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