Pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection with profound teratospermia

McKenzie, Laurie J.; Kovancı, Ertuğ; Amato, Paula; Cisneros, Pauline; Lamb, Dolores J.; Carson, Sandra Ann

doi:10.1016/j.fertnstert.2004.03.054

Cited by 33 publications

(24 citation statements)

References 15 publications

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“…Therefore, we can speculate that the absence of pregnancy in the non-pregnant group, who had displayed low sperm parameters, could be associated with the deterioration in the sperm morphology, thus leading to genetic embryo abnormalities, lack of implantation and/or early miscarriage. It has been documented in various publications that morphology in human spermatozoa, according to strict criteria, WHO criteria and the teratozoospermia index has no predictive value for the outcome after either IVF or ICSI [19][20][21]. In addition, there is no consensus on the direct relationship between spermatozoa morphology and genetic abnormalities.…”

Section: Discussionmentioning

confidence: 99%

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Male age influences oocyte-donor program results

Girsh

Katz

Genkin

et al. 2008

J Assist Reprod Genet

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Background The purpose of our research was to examine the relationship between male age and semen parameters in a range of ages (from 20s to 60s) in Egg Donation Program (EDP) cycles. EDP provides a pool of high quality oocytes, thus allowing better analysis of the sperm efficacy. Discussion The retrospective study population consisted of 484 male partners of patients undergoing EDP in in-vitro fertilization (IVF) treatments. A comparison was made of male age and sperm parameters within two groups: cycles resulting in a pregnancy (pregnant group) and cycles which failed to achieve a pregnancy (non-pregnant group). The men involved in the pregnant group were found to be significantly younger 43.2±8.1 than those of the nonpregnant group 46.8±7.8 (p=0.003). Analysis of sperm morphology revealed a significant prevalence of teratozoospermia in males of the non-pregnant group, as compared to the males of the pregnant group (29% vs. 11%, respectively). The results also demonstrate that sperm parameters are apparently not diminished until men reach the age of 40. However, between 40-50 years old semen parameters deteriorate. Male age was found to be related to a reduction in sperm strict criteria: 44.8 in normozoospermia, 47.9 (p=0.02), 48.4 (p=0.04) and 51.9 (p=0.001) years old in mild teratozoospermia, moderate teratozoospermia and severe teratozoospermia, respectively. Additionally, the results showed that the percentage of "healthy" embryos on day 3 of embryo culture was lower in the non-pregnant group (26%), as compared with the pregnant group (34%; p=0.01). Conclusion Our study confirms that sperm parameters are reduced by age and suggests that this age-dependent effect could be a reason for failures in IVF cycles even in EDP couples.

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Section: Discussionmentioning

confidence: 99%

“…Young women, of an average age of 24 (range [20][21][22][23][24][25][26], were accepted into the Egg Donation Program (EDP) cycles. All of these women were healthy, had normal menstrual cycles and no determined pathology.…”

Section: Oocytes Donation and Fertilizationmentioning

confidence: 99%

Male age influences oocyte-donor program results

Girsh

Katz

Genkin

et al. 2008

J Assist Reprod Genet

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“…Cependant, la majoritd des auteurs n'ont pas retrouv6 de relation entre la morphologie du sperrne et le succ~s de I'ICSI [20,36,31]. Quatre explications ont ~t~ propos~es.…”

Section: Mots Cl6sunclassified

“…En ICSl, cette relation entre la morphologie et le pouvoir f6condant n'est pas verifi~e car le crit~re ultime de la r6ussite d'une ICSl est la presence d'au moins un spermatozo'ide vivant normal par ovocyte [31]. Cependant, la relation potentielle entre la forme des spermatozofdes et leur int6grit~ g~n~tique est devenue pertinente depuis I'introduction de I'ICSI, car dans cette proc6dure, ia s~lection ne se base pas sur I'interaction entre le spermatozo'fde et la zone pellucide, comme dans la FIV, mais sur la visualisation de la forme du spermatozo'ide et de ses anomalies par le biologiste.…”

Section: Impact De La Morphologie Des Spermatozo[des Sur La Fertilitrunclassified

Sperm morphology examination

Saïdi

Gruel

Roset-Blessman

et al. 2008

Androl.

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Mots cl6s : infertitit6, morphologie, spermatozoi'de, t6ratozoospermie I. INTRODUCTION L'exarnen du sperme (sperrnogramme -spermocytogramme) constitue une des ~tapes clefs dans rexploration du couple infertile. /'~jaculat normal contient des spermatozoi'des pr~sentant des variations importantes de la taille et de la forme de la t~te, de I'acrosome, de la pi(bce interm~diaire et du flagelle. Cette h6terog~n6it~ s'explique par le fait que le sperrnatozd[de, ceUule hautement diff~renci~e, est le r~sultat ultime d'un processus complexe : la spermatogen~se. Ce processus peut ~tre la cible de facteurs toxiques endog~nes ou exog~nes qui peuvent induire la production excessive de spermatozoides morphologiquement anormaux responsable d'une t~ratozoospermie. Une morphologie anormale des spermatozofdes peut comprornettre le pouvoir f6condant d'un sperme. Cependant, le profil morphologique du sperrne semble ~tre le param~tre sperrnatique le plus constant chez un homme [12,19,30,36].La morphologie du sperme a et~ reconnue comme le meilleur facteur pr~dictif de la fertilit~ naturelle ou de I'issue en inseminations intra ut~rines (IIU) ou en f6condation in vitro (FIV) classique [8,38]. Cependant, la majoritd des auteurs n'ont pas retrouv6 de relation entre la morphologie du sperrne et le succ~s de I'ICSI [20,36,31]. Quatre explications ont ~t~ propos~es. Premi~rement, une morphologie normale du spermatozoi'de est requise pour le passage des barri~res ovocytaires qui sont court-circuit~es par I'ICSI. Deuxi~mement, les spermatozdfdes portant des anomalies morphologiques ~videntes ne sont pas retenus pour rinjection. Troisi~mement, le spermocytogramme r~alis~ sur des ceUules randomisees de I'~jaculat n'est pas le reflet exact de la qualit6 du spermatozoi"de inject6. Quatri~mement, les Correspondance :Pr Nathalie RIVES -Laboratoire de Biologie de la I rue de Germont, CHU H6pitaux de Rouen, 76031, 158 anomalies ultrastructurales qui sont les seules associees au devenir de I'ICSI ne peuvent pas (~tre d~tect~es ni au grossissement xl00, ni au grossissement x200-400 [4,6]. L'analyse morphologique du sperme ou spermocytogramme est une dtude descriptive de la forme des spermatozofdes partir d'un ~chantillon repr6sentatif d'un 6jaculat. La morphologie n'est qu'un des param~tres qualitatifs de la spermatogen~se. Cette analyse est d~pendante des techniques d'imagerie utilisdes et des criteres d'interprdtation adopt6s pour ddfinir un spermatozo'ide morphologiquement normal. II. MICROSCOPIE OPTIQUEC'est la mdthode la plus utilisde et elle fait partie des examens de routine du fait de son faible coot et de sa simplicitY. L'analyse morphologique des spermatozoi'des est faite partir de preparations fixdes et colordes examinees en lumi~re transmise au grossissement final xl000 (objectif 100 immersion). Mdthodes de colorationPlusieurs colorations sont possibles : Giemsa, coloration de Papanicolaou modifiee pour les spermatozoides (PAP), coloration de Bruyan-Leishman ou encore coloration de SchorT. D'apr~s certains auteurs, la coloration de...

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“…For example, few studies indicate that fertilization, embryo development and pregnancy is possible even if normal spermatozoa are not available (100% of teratozoospermia). 13,[27][28][29] Whereas a few other studies have found that fertilization, pregnancy and also implantation rates are adversely affected when sperms with severe abnormalities were used for ICSI. 17,19,30 One more study in 2001 also concludes into saying that sperm morphology is significantly correlated to the percentage of embryos developing to the blastocyst stage (30.3% vs 51.9%) and to high quality blastocysts (13.6% vs 28.2%).…”

Section: Discussionmentioning

confidence: 99%

Intracytoplasmic Morphologically selected Sperm Injection vs Intracytoplasmic Sperm Injection: A Retrospective Analysis

Dalal¹,

Palshetkar²,

Mishra³

2011

International Journal of Infertility &Amp; Fetal Medicine

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This study was conducted to determine the efficacy of using the technique of intracytoplasm morphologically selected sperm injection (IMSI) as compared to the conventionally used intracytoplasmic sperm injection ((ICSI) procedure. IMSI, as the name suggests, is the technique of selecting the most normal looking sperm by magnifying it to about 7200 times. A total of 192 patients who underwent the treatment of in vitro fertilization (IVF) with us by either one of the two procedures of IMSI or ICSI over a period of 18 months were included in the study. Out of these 92 were included in the IMSI group while 100 others in the ICSI group according to our inclusion and exclusion criteria. The pregnancy rate among patients who underwent IMSI was found to be significantly higher (52.1%) as compared to those with ICSI (36%). Furthermore, even the implantation rates were higher in the IMSI group (30.12%) than the ICSI (19.93%) group.

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Pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection with profound teratospermia

Cited by 33 publications

References 15 publications

Male age influences oocyte-donor program results

Male age influences oocyte-donor program results

Sperm morphology examination

Intracytoplasmic Morphologically selected Sperm Injection vs Intracytoplasmic Sperm Injection: A Retrospective Analysis

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