Pregnancy outcomes after fertility preservation in women with endometrial carcinoma and atypical endometrial hyperplasia: A systematic review and meta-analysis

Xiao, Zerui; Song, Ziyi; Wang, Jianliu; Liu, Huixin; Lü, Qun

doi:10.1016/j.gocm.2021.07.004

Cited by 3 publications

(7 citation statements)

References 27 publications

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“…A clinical pregnancy will be defined as at least one intrauterine pregnancy sac with yolk sac or original cardiac pulsations on a B-ultrasound examination. A live birth will be defined as the birth of a healthy infant not requiring admission to the neonatal intensive care unit, at 28 weeks gestation or more, during the follow-up period [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

Fertility Preservation Techniques in Neuro-Oncology Patients: Protocol for a Systematic Review

Osborne-Grinter¹,

Bianca²,

Sanghera³

et al. 2023

JMIR Res Protoc

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Background Advancements in cancer treatments have successfully improved central nervous system (CNS) cancer survivorship and overall quality of life. As a result, the awareness of the importance of fertility preservation techniques is increasing. Currently, a range of established techniques, such as oocyte cryopreservation and sperm cryopreservation, are available. However, oncologists may be hesitant to refer patients to a reproductive specialist. Objective The primary aim of the proposed systematic review is to assess the best evidence for fertility preservation techniques used in patients with CNS cancers. It also aims to evaluate outcomes related to their success and complications. Methods This protocol was produced in adherence with the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols). Electronic databases will be systematically searched to identify studies that meet our eligibility criteria. Studies will be included if they report at least one type of fertility preserving or sparing technique in male patients of any age and female patients aged <35 years. Animal studies, non-English studies, editorials, and guidelines will be excluded from the review. From the included studies, data will be extracted and synthesized by using a narrative approach and summarized in tables. The primary outcome will be the number of patients successfully undergoing a fertility preservation technique. The secondary outcomes will include the number of retrieved oocytes, the number of oocytes or embryos vitrified for cryopreservation, clinical pregnancy, and live birth. The quality of the included studies will be assessed by using the National Heart, Lung, and Blood Institute risk-of-bias tool for any type of study. Results The systematic review is expected to be completed by the end of 2023, and results will be published in a peer-reviewed journal and on PROSPERO. Conclusions The proposed systematic review will summarize the fertility preservation techniques available for patients with CNS cancers. Given the improvement in cancer survivorship, it is becoming increasingly important to educate patients about fertility preservation techniques. There are likely to be several limitations to this systematic review. Current literature is likely to be of low quality due to insufficient numbers, and there may be difficulty in accessing data sets. However, it is our hope that the results from the systematic review provide an evidence base to help inform the referral of patients with CNS cancers for fertility preservation treatments. Trial Registration PROSPERO CRD42022352810; https://tinyurl.com/69xd9add International Registered Report Identifier (IRRID) PRR1-10.2196/44825

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Section: Methodsmentioning

confidence: 99%

Fertility Preservation Techniques in Neuro-Oncology Patients: Protocol for a Systematic Review

Osborne-Grinter¹,

Bianca²,

Sanghera³

et al. 2023

JMIR Res Protoc

View full text Add to dashboard Cite

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“…In a retrospective study of 107 AEH/EC patients by Xiao Zerui et al. ( 21 ), the pregnancy rate was 37.5% in patients with comorbid diabetes mellitus and 40.9% in patients with comorbid IR. The above data suggest a less favorable pregnancy rate in AEH/EC patients with combined MetS.…”

Section: Factors Affecting Pregnancy Outcomes Of Art Treatment In Aeh...mentioning

confidence: 99%

“…In a retrospective study of 107 AEH/EC patients, Xiao Zerui et al. ( 21 ) showed that the clinical pregnancy rate in patients with uterine adhesions was lower than that in patients without it. Elizur et al.…”

Section: Factors Affecting Pregnancy Outcomes Of Art Treatment In Aeh...mentioning

confidence: 99%

Current research of Assisted Reproductive Technology for women with early endometrial cancer and atypical endometrial hyperplasia after conservative treatment

Jiang,

Lin,

Chen

et al. 2024

Front. Endocrinol.

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As the incidence of endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) has been increasing, and has shown young trend. It is crucial to study the fertility-preserving treatment of endometrial lesions and fertility-promoting protocols. Age, obesity, and irregular ovulation are not only high-risk factors for endometrial lesions but also key factors affecting female fertility. Assisted reproductive technology (ART) can significantly improve pregnancy outcomes in patients with AEH and EC after conservative treatment. Based on the existing studies, this article reviews the progress of research on pregnancy outcomes of ART and its influencing factors in such patients. It helps physicians in providing optimal fertility guidance.

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“…She was given a levonorgestrelreleasing intrauterine device (LNG-IUD) as the maintenance treatment and a referral to a reproductive specialist. Two months after CR, IVF-ET was recommended for her due to the high pregnancy rate than spontaneous pregnancy in EC [3] . Her anti-mullerian hormone (AMH) was 3.528ng/ml, serum basic folliclestimulating hormone (FSH) was 7.62IU/L, and antral follicle count (AFC) was 13, then ovarian reserve was normal.…”

Section: Case Reportmentioning

confidence: 99%

“…Preoperative chemotherapy can also be recommended to reduce tumor focus of which the preferred regimens include carboplatin and paclitaxel [2] . This complicated treatment should be formulated after a comprehensive preoperative discussion with the multi-disciplinary team (MDT) [3] .…”

Section: Introductionmentioning

confidence: 99%

A Successful Live Birth Through In Vitro Fertilization and Embryo Transfer in Stage IVb Endometrial Carcinoma after Conservative Treatment: a Case Report

Xiao,

Song,

Zhao

et al. 2023

Preprint

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Introduction An increasing number of young patients with early-stage endometrial cancer are opting for fertility-sparing treatment, and they have achieved reassuring rates of complete remission, with some women achieving pregnancy. However, surgical treatment is still recommended for patients with advanced endometrial cancer. We reported a woman with IVb endometrial cancer (EC) who reached complete remission (CR) and gained a live birth successfully with the help of in vitro fertilization and embryo transfer (IVF-ET). Case report A 30-year-old woman found to have stage IVb EC after hysteroscopy, laparoscopy, and pathological examination. After a combination of chemotherapy and progesterone therapy, the woman achieved complete remission. The woman became pregnant with IVF-ET and got a full-term live birth. In addition, there was no recurrence after 19 months of observation. The molecular classification of POLE and the combination of chemotherapy and progesterone therapy may be associated with a good prognosis of this patient. The use of progestin-primed ovarian stimulation (PPOS) and the combination of letrozole and levonorgestrel-releasing intrauterine device (LNG-IUD) during ovulation induction seemed to be safe for the woman Conclusion This is the first report on fertility-sparing treatment and live birth for advanced EC. IVF-ET is feasible for women with EC who preserve reproductive function. The progestin-primed ovarian stimulation combined with levonorgestrel-releasing intrauterine device and letrozole seems to be safe for these women. Patients still need to be closely watched for tumor recurrence.

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Pregnancy outcomes after fertility preservation in women with endometrial carcinoma and atypical endometrial hyperplasia: A systematic review and meta-analysis

Cited by 3 publications

References 27 publications

Fertility Preservation Techniques in Neuro-Oncology Patients: Protocol for a Systematic Review

Fertility Preservation Techniques in Neuro-Oncology Patients: Protocol for a Systematic Review

Current research of Assisted Reproductive Technology for women with early endometrial cancer and atypical endometrial hyperplasia after conservative treatment

A Successful Live Birth Through In Vitro Fertilization and Embryo Transfer in Stage IVb Endometrial Carcinoma after Conservative Treatment: a Case Report

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