Pregnancy Outcomes in Women With Thyroid Peroxidase Antibodies

Abbassi-Ghanavati, Mina; Casey, Brian M.; Spong, Catherine Y.; McIntire, Donald D.; Halvorson, Lisa M.; Cunningham, F. Gary

doi:10.1097/aog.0b013e3181e904e5

Cited by 109 publications

(79 citation statements)

References 18 publications

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“…Our findings were similar to that of Abbassi-Ghanavati and associates who did not find any increased risk for preterm birth in TPO positive women compared with the risk in euthyroid women with TPOAb -ve. 10 Our results of preeclampsia and preterm labour may be due to very less numbers. It could have been overcome if sample size becomes larger.…”

Section: Discussionmentioning

confidence: 78%

Anti-thyroid peroxidase antibody positivity and other obstetric complications in women with recurrent miscarriage

Jaiswal

Bag

2016

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONMiscarriage is defined as any pregnancy ending spontaneously prior the fetus can survive. Recurrent miscarriage, defined as loss of 3 or more consecutive pregnancies affects 1% of couples trying to conceive. The etiology of recurrent spontaneous miscarriage includes epidemiological factors such as maternal age and number of previous miscarriages, anti-phospholipids syndrome, genetic factors, anatomical factors, endocrine factors, immune factors; inherited thrombophillic defects. 1 Women with RPL can be classified into three separate groups, as primary, secondary and tertiary aborters. Primary aborters are women with no previous live birth, secondary aborters if there was a live birth followed by pregnancy losses, and tertiary aborters are women who had pregnancy losses followed by a live birth. ABSTRACTBackground: Thyroid dysfunction and autoimmunity are relatively common in women of reproductive age group and has been associated with various adverse pregnancy outcomes such as recurrent miscarriage, preeclampsia and preterm labour. The aim of this study was to find out association between anti-tpo antibody and recurrent miscarriage and to evaluate obstetric complications such as preeclampsia and preterm labour in them. Methods: This case control observational study was carried out from July 2014 to June2015 on 110 pregnant mothers out which 55 with history of recurrent miscarriage were cases and 55 without such history were controls. Results: The mean age of the cases were 24.18 yrs. Majority of pregnancy losses occurred between 9-14wks.The prevalence of anti-tpo antibody positivity in the study population was 15.45%.out of 55 cases 12 were positive for anti-tpo antibody(21.8%).Positive anti-tpo antibody was associated with high TSH level than the negative anti tpo antibody(p<.000).The prevalence of preeclampsia and preterm labour in recurrent miscarriage patients were 9.09% and 5.45% respectively which was not significantly higher than background risk.1 out of 5 patients with preeclampsia had anti-tpo positive and none with preterm labour had anti-tpo antibody positivity. Conclusions: The prevalence of thyroid autoimmunity was higher in patients with history recurrent miscarriage history than the control population. Even in women with biochemically normal thyroid function there was relationship between recurrent miscarriage and thyroid autoimmunity. Thus anti-tpo antibody could be risk marker for RSM. Screening for subclinical hypothyroidism (TSH >2.5 but<10) and anti-tpo antibody can be suggested as these identify women with increased risk of miscarriage.

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Section: Discussionmentioning

confidence: 78%

Anti-thyroid peroxidase antibody positivity and other obstetric complications in women with recurrent miscarriage

Jaiswal

Bag

2016

Int J Reprod Contracept Obstet Gynecol

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“…Multiple observational studies [63,64,65] and 2 meta-analyses [66,67] have confirmed a 2-4 fold risk of miscarriage among euthyroid TPO antibody-positive women, compared to euthyroid TPO antibody-negative women. Some studies [68,69] but not all [70,71], have also found associations between thyroid autoimmunity and increased rates of recurrent miscarriage.…”

Section: Thyroid Auto-immunitymentioning

confidence: 99%

11 Hypothyroidism in Pregnancy

Lazarus¹,

Pīrāgs²,

Butz³

2009

The Thyroid and Reproduction

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“…Serum TSH level [3 mu/l and normal range free T4 were considered as subclinical hypothyroidism [11]. Normal serum TSH level and free T4 \0.86 ng/dl were considered as maternal hypothyroxinemia [22,23].…”

Section: Methodsmentioning

confidence: 99%

“…Although many types of antithyroid antibodies have been described, the most common is the group of antibodies directed against various parts of the thyroid peroxidase molecule [24][25][26]. Most pregnant women with abnormally elevated serum levels of thyroid peroxidase antibodies are clinically and biochemically euthyroid, but they may be at increased risk of spontaneous abortion, and preterm delivery and other pregnancy complications [11,27].…”

Section: Observationmentioning

confidence: 99%

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Pregnancy Outcome in Euthyroid Women with Anti-Thyroid Peroxidase Antibodies

Meena

Nagar

2015

J Obstet Gynecol India

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Objective The aim of this study was to compare pregnancy outcomes in euthyroid women who were anti-TPO Ab ? with those who were anti-TPO Ab -. Design This observational study comprised 1,000 women in the age group of 25-35 years, having normal thyroid function tests, normotensive, non-diabetic, singleton pregnancy and attending Gyn. OPD/ANC up to 20 weeks' gestation and those who were already in the process of abortion. anti-TPO Ab levels of[50 IU/ml were considered as anti-TPO Ab ? . Setting This study was conducted in the SMS Medical College's attached hospital, Jaipur from April 2012 to September 2013. Main Outcome The estimation of the proportion of anti-TPO Abs in the hospital-based population and the comparison of pregnancy and neonatal outcomes in anti-TPO Ab ? and Ab -euthyroid women were done. Results The main result showed increased rates in miscarriages (13.33 vs. 2.34 %, P \ 0.001), LBWs (25 vs. 5.12 %, P \ 0.001), preterm deliveries [\34 weeks] (5 vs. 1.80 %, P [ 0.05) in anti-TPO Ab ? women. Conclusions The current study revealed that anti-TPO Abs are strongly associated with miscarriage and LBW irrespective of their gestational age. However, we did not find any correlation with the other complication as found in the studies by Abbassi-Ghanavati, Negro et al.

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Pregnancy Outcomes in Women With Thyroid Peroxidase Antibodies

Abstract: II.

Cited by 109 publications

References 18 publications

Anti-thyroid peroxidase antibody positivity and other obstetric complications in women with recurrent miscarriage

Anti-thyroid peroxidase antibody positivity and other obstetric complications in women with recurrent miscarriage

11 Hypothyroidism in Pregnancy

Pregnancy Outcome in Euthyroid Women with Anti-Thyroid Peroxidase Antibodies

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