Objective The aim of this study was to compare pregnancy outcomes in euthyroid women who were anti-TPO Ab ? with those who were anti-TPO Ab -. Design This observational study comprised 1,000 women in the age group of 25-35 years, having normal thyroid function tests, normotensive, non-diabetic, singleton pregnancy and attending Gyn. OPD/ANC up to 20 weeks' gestation and those who were already in the process of abortion. anti-TPO Ab levels of[50 IU/ml were considered as anti-TPO Ab ? . Setting This study was conducted in the SMS Medical College's attached hospital, Jaipur from April 2012 to September 2013. Main Outcome The estimation of the proportion of anti-TPO Abs in the hospital-based population and the comparison of pregnancy and neonatal outcomes in anti-TPO Ab ? and Ab -euthyroid women were done. Results The main result showed increased rates in miscarriages (13.33 vs. 2.34 %, P \ 0.001), LBWs (25 vs. 5.12 %, P \ 0.001), preterm deliveries [\34 weeks] (5 vs. 1.80 %, P [ 0.05) in anti-TPO Ab ? women. Conclusions The current study revealed that anti-TPO Abs are strongly associated with miscarriage and LBW irrespective of their gestational age. However, we did not find any correlation with the other complication as found in the studies by Abbassi-Ghanavati, Negro et al.

Objective(s):To evaluate the effectiveness of uterine balloon therapy for the treatment of menorrhagia and to determine its prognostic factors. Method(s): Seventy five patients were treated with uterine balloon therapy with thermachoice II for intractable menorrhagia without detectable pathology and the results were statistically analyzed regarding procedure efficacy, safety, side effects and prognostic factors at follow-up periods of one month, three months, six months and 12 months. Results(s): After undergoing uterine balloon therapy, 41.30% patients attained eumenorrhea, 30.43% hypomenorrhea and 15.21% amenorrhea at the end of 12 months follow-up. Retroverted uterus, prolonged duration of menstruation, endometrial thickness of at least 9mm and uterine depth >10 cm were associated with an increased risk of treatment failure. Conclusion(s): Uterine balloon therapy is an efficient and reliable modality to treat women with intractable menorrhagia especially those who have completed their families but do not want to part with their uterus which of course is without any organic pathology.

Objective:To analyze the risk factors associated with mortality in COVID-positive pregnant women. Material and methods:The study was designed as a case-control study and was conducted at COVID-designated tertiary care hospital. It included 42 deceased and 96 RT-PCR-positive surviving pregnant women who developed severe forms of disease. All the affected patients were admitted and managed according to Indian national guidelines. Risk factors -age, residence, socioeconomic status, gestation age, parity, and comorbidities were evaluated for their association with mortality. Results: Advanced maternal age (>28 years), rural residence, diabetes, and comorbidities were found to be associated with increased risk of mortality among the COVID-affected pregnant women, the respective adjusted odds ratio was 15.45, 12.61, 2.65, and 4.77, respectively. Conclusion: Pregnant women are vulnerable to COVID infection. They were at higher risk of mortality with comorbidities, advanced age, and low access to healthcare in the rural areas.