Pregnancy rates after conservative treatment for borderline ovarian tumours: A systematic review

Swanton, Alexander; Bankhead, Clare; Kehoe, Sean

doi:10.1016/j.ejogrb.2007.05.011

Cited by 51 publications

(29 citation statements)

References 23 publications

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“…Histologically, the majority of BOTs are serous or mucinous; however, they may also have clear cell, endometrioid, Brenner (transitional cell) or mixed histology. Women with BOT are significantly younger than those with invasive ovarian cancers; up to 45% of these patients being younger than 40 years [2,3]. BOT patients are more likely to have early stage disease than those with invasive cancers and generally have an excellent prognosis, even after conservative surgery.…”

Section: Introductionmentioning

confidence: 98%

The preoperative diagnosis of borderline ovarian tumors: a review of current literature

Morotti

Menada

Gillott

et al. 2011

Arch Gynecol Obstet

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After completion of this article, the reader should be aware of the symptoms of BOTs, the potential role and pitfalls of tumor marker measurement. In addition, the reader will understand the appearance of BOTs at imaging techniques; the reader will be able to compare and combine ultrasonography, MRI and positron emission tomography in diagnosing BOTs. In clinical practice, the reader should be better able to assess whether an ovarian mass is a benign tumor, a BOT or an invasive cancer.

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Section: Introductionmentioning

confidence: 98%

The preoperative diagnosis of borderline ovarian tumors: a review of current literature

Morotti

Menada

Gillott

et al. 2011

Arch Gynecol Obstet

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“…10,11 A review identified 254 pregnancies in 206 patients; the investigators calculated the overall pregnancy rate at 48%, based on the published numbers of women trying to conceive. 12 Another study reported 60%-88% of spontaneous pregnancy rates following fertility saving surgery, therefore not justifying overtreatment for fertility. 13 Fifty months postsurgery, the patient was clinically well and not planning further pregnancies; therefore, she decided to undergo a hysterectomy and a contralateral salpingooopherectomy.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Borderline Tumor and Fertility-Sparing Surgery

Reis

Gomes

Freire

et al. 2013

Journal of Gynecologic Surgery

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Background: Ovarian borderline tumors (OBTs) are frequently diagnosed in women of reproductive age. There is no consensus about their management, and it sometimes represents a dilemma about what should be done: fertilitysparing surgery or a hysterectomy with salpingo-oophorectomy? Case: A 32-year-old nulligravida, diagnosed with a right ovarian borderline tumor is presented. She underwent pelvic washings, right salpingo-oophorectomy, appendectomy, and omental and peritoneal biopsies (laparotomic approach). Macroscopically, the left ovary was normal and subsequent exploration for staging was also normal, including the lymph nodes. Intraoperatively, frozen section examination was unclear, suggesting an OBT. Results: The final histopathologic diagnosis was ovarian borderline tumor, stage IIC (International Federation of Gynecology and Obstetrics [FIGO] staging). The patient expressed a desire to preserve her fertility. Thirty-six months postsurgery, she became pregnant spontaneously and delivered a healthy newborn at term. Conclusions: Conservative surgery can be performed in young patients treated for an OBT, provided they are closely followed up and that this surgery is performed after careful consideration and informed consent. It is, however, controversial with respect to performing hysterectomy and salpingo-oopherectomy upon the patient's completion of childbearing. ( J GYNECOL SURG 29:292)

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“…In a meta-analysis including 2479 BOT patients, (24) . Compared to the literature results, in our series pregnancy ratio is low and we believe the reasons for this are; our relatively shorter mean followup time, infertility in addition to borderline ovary tumor, the fact that some of the patients are single or don't have a partner and new pregnancy postponing of the cases who have children.…”

Section: Discussionmentioning

confidence: 99%