Pregnane glycoside from Hemidesmus indicus as a potential anti-oxidant and anti-dyslipidemic agent

Abstract

A new pregnane glycoside hindicusine (1) was isolated from the CHCl(3)-EtOH (3 : 2) extract of Hemidesmus indicus, whose structure was established on the basis of spectroscopic studies. The glycoside (1) and its acetylated derivative (5) were evaluated for their anti-oxidant and anti-dyslipidemic activities.

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

“…The active principles of Hemidesmus indicus, 2-hydroxy 4-methoxy benzoic acid and pregnane glycoside, showed antihyperlipidaemic and antidyslipidemic effects [180, 181]. …”

Hypolipidemic, Hypoglycemic and Anti-oxidant Activities of Flower Extracts of <i>Allamanda Violacea</i> A. DC (Apocynaceae)

“…We reported earlier that some precursors in hormone synthesis, such as, guggulsterone, possess lipid-lowering activity, together with mild anti-oxidant effect and also inhibit oxidative modification of LDL [6]. Recently, we also found that some pregnane derivatives exhibited antioxidant and anti-dyslipidemic activities simultaneously [7,8].…”

“…Animals, which were acclimatized for one week before starting the experiment, had free access to normal diet and water ad libitum [7,8] …”

The Bioactive and Therapeutic Potential of Hemidesmus indicus R. Br. (Indian Sarsaparilla) Root

“…Chatterjee and Bhattacharya, 1955;Das and Devaraj, 2007;2008 Glycosides Hindicusine, hemidesmosides A-C Anti-adhesive, antioxidant and anti-dyslipidemic. Das and Devaraj, 2006b;Sethi et al, 2010;Zhao et al, in press Tannins Unspecified Mucoprotective, antidiarrhoeal. Kostova, 2005 Aliphatic acids Dodecanoic acid, hexadecanoic acid, linalyl acetate, dihydrocarvyl acetate, hexatriacontane The aqueous extract, 100 mg/kg, administered prior to bromobenzene, showed significant beneficial effects including respiratory stimulation, prevention of the rise in lipid peroxides and protein carbonyls, and increased the level of sulphydryl groups back to control levels.…”