Pregnane Glycosides

Abstract

Pregnane glycosides constitute a class of compounds widely distributed in the plant kingdom. Many of them have shown either anticarcinogenic or cancer inhibitory properties, besides other useful biological activities. New chromatographic techniques and advances in spectroscopic and spectrometric methods have accelerated the purification and structure determination of novel glycosides of this series. A compilation of the pregnane glycosides isolated from 1995 until the middle of 2005, along with their physical data, structures and occurrence are presented in this review, which also summarizes, with suitable examples, recent developments in isolation and purification techniques, and structural elucidation using modern spectrometric methods like ESIMS and tandem mass spectrometry, and 2D NMR spectroscopic strategies. The reported anticancer and other biological activities of pregnane glycosides are also discussed.

Phytochemicals and Biological Activity of Desert Date (Balanites aegyptiaca (L.) Delile)

“…Pregnane glycosides are naturally occurring sugar conjugates of C 21 steroidal compounds, isolated from various plants and many show anticarcinogenic properties [ 45 ]. Pregn-5-ene-3β,16β,20(R)-triol 3-O-(2,6-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside ( 42 ) and pregn-5-ene-3β,16β,20(R)-triol 3-O-β-D-glucopyranoside ( 43 ) were extracted from the fruits of desert date ( Table 5 ; Figure 4 ) [ 28 ].…”

Pregnane-type steroidal glycosides from Gymnema griffithii Craib.

“…In these molecules, the sugar moiety is mostly linked at the C-3 position of the aglycone and generally occurs as a linear rather than a branched oligosaccharide chain (Panda et al, 2006). In recent years, several studies have reported that pregnane glycosides have considerable bioactivity, including compounds with antiproliferative (Cioffi et al, 2006;Plaza et al, 2005), cytotoxic (Braca et al, 2002;De Leo et al, 2005;Chen et al, 2010;Waheeda et al, 2011;Al-Massarani et al, 2012), antifungal (Yoon et al, 2011) and antidepressant (Yang et al, 2011) activities.…”

Serum Biochemical, Histopathology and SEM Analyses of the Effects of the Indian Traditional Herb Wattakaka Volubilis Leaf Extract on Wistar Male Rats

“…The available literature reveals that more than 400 Indian plant species have hypoglycemic potential [ 7 , 8 ]. Wattakaka (W.) volubilis is in the family asclepiadaceae and is grown throughout the hotter parts of India [ 9 ]. The leaf parts of the plant are used traditionally as medicines to treat rheumatic pain, cough, fever, severe cold and dyspepsia.…”